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Solution behaviour prevailing in 1, 3-dimethylimidazoliummethylsulfate (IL) and some diverse industrially important alkoxy-alcohols or cellosolves have been investigated by electrolytic conductivity, density (⍴), viscosity (η) and FT-IR spectroscopic investigation. The derived parameters such as the limiting molar conductivities (Λ0), association constants (KA), the distance of closest approach (R), etc. of the ions supplemented with conductance, density and viscosity have been evaluated using the Fuoss conductance equation. The quantitative values of molecular interactions from thermodynamic parameters have been discussed in terms of some non-covalent interactions. Functional groups of the pure solvents and structural characteristics of ionic liquid in different solvents have been discussed and taken into contemplation for spectroscopic study.

The water soluble inclusion complexes of pyridinium based hydrophobic ionic liquid (IL) were prepared and characterised successfully. The inclusion complexes of sparingly soluble IL prepared with α‐ and β‐cyclodextrin in the mixed solvent medium and in solid state were studied by different physicochemical methodologies. Comparison of the chemical shift of the pure CDs, guest and complexes formed in 1‐H NMR spectra, appearance of the cross peaks in 2D‐ROESY spectra and shift in the band positions in FT‐IR spectra confirmed the formation of inclusion complexes. Surface tension and conductance studies in the mixed solvent system indicated the 1:1 stoichiometric ratio of inclusion complex. Job's plot obtained from UV‐Vis study and the spectra obtained from mass spectrometric study supported the formation as well as the stoichiometry of inclusion complexes. The high binding constant values and calculated values of thermodynamic parameters such as Gibb's free energy, enthalpy and entropy supported the high stability and feasibility of formation of the inclusion complex.

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Steady host–guest inclusion complexes have been produced with medicinally important guest molecule theophylline within aqueous α-Cyclodextrin and HP-β-Cyclodextrin. α-and HP-β-Cyclodextrins have been established with favorable structural features for inclusion with Theophylline which include diversified applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing, pesticides, foodstuffs etc. Theophylline is one of the most widely accepted drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, even if it has been used clinically for many years. With both α and HP-β-Cyclodextrins it is found that 1:1 hosts-guest inclusion complexes are formed with the guest molecule theophylline. The construction and quality of the inclusion complexes have been characterized by using conductivity measurement, surface tension study, and Job’s method. The inclusion phenomenon has been confirmed by FTIR spectroscopy, proton NMR study. Association constants and thermodynamic parameters have been evaluated for the created inclusion complexes by ultraviolet spectroscopy.

Paramita Karmakar, et al., Probing subsistence of host guest inclusion complexes of oligosaccharides with allopurinol for regulatory release with the manifestation of solvation consequences, J. Adv. Chem. Sci. 5(1) (2019) 621-628. The inspection of molecular interaction widespread in allopurinol and in aqueous solutions of α-, -and HP-β-cyclodextrin have been probed by thermophysical properties. The established complexes obtained with 1:1 stoichiometry. Role of solvent (aqueous solution of α-CD, -CD, HP-β-CD) and contribution of solute-solute and solute-solvent interactions to solution complexes, have also been analyzed via stability constant-NMR, UV, steady state fluorescence, FTIR, HRMS, SEM, PXRD, cytotoxicity, hydrophobic effect, hydrogen-bonding, structural effects in creation of inclusion complexes. Cite this Article as: Jaygopal Mondal, Ashutosh Dutta, Koyeli Das, Debasmita Das, Paramita Karmakar, et al., Probing subsistence of host guest inclusion complexes of oligosaccharides with allopurinol for regulatory release with the manifestation of solvation consequences, J. Adv. Chem. Sci. 5(1) (2019) 621-628.