Sustained Release from Inert Wax Matrixes III: Effect of Povidone on Tripelennamine Hydrochloride Release

Designing an extended release waxy matrix tablet containing nicardipine–hydroxy propyl β cyclodextrin complex

“…This result leads to enhance the penetration of dissolution medium into the matrix and to facilitate creating of more pores inside the tablet as well as more swelling of avicel particles. This leads to increase in the wettability and to rapid solvent penetration inside the tablets to dissolve the drug more rapidly and to get diffused out (Dakkuri et al, 1978;El-Shanawany, 1993;Nakai et al, 1977;Bhi Said and Al-Shora, 1980). It is concluded that the key of the preparation of plastic matrix is dependent mainly on the controlling of the percent of PEG4000 and GMS during the preparation of fusion complex.…”

“…(1), n values for F2-F4 and F6-F7 were less than 0.45 which indicate that the release comply Case I or Fickian diffusion, which may be due to the leaching of drug by the eluting medium (Table 4). Fluid enters through the cracks and pores of the matrix with diffusion of drug through the matrix being insignificant (Dakkuri et al, 1978;Dredan et al, 1998). The higher rate and extent of NC released in the first two hours (within acidic medium) was due to greater extraction of NC from the vicinity of the matrix surface.…”

A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

“…diphenhydramine HCl [161], tripelennamine HCl [162]) and hydrophilic matrix tablets (e.g. metoprolol tartarate [163], cefpodoxime proxetil [164], isoniazid [165]) are reported in the literature.…”