“…This result leads to enhance the penetration of dissolution medium into the matrix and to facilitate creating of more pores inside the tablet as well as more swelling of avicel particles. This leads to increase in the wettability and to rapid solvent penetration inside the tablets to dissolve the drug more rapidly and to get diffused out (Dakkuri et al, 1978;El-Shanawany, 1993;Nakai et al, 1977;Bhi Said and Al-Shora, 1980). It is concluded that the key of the preparation of plastic matrix is dependent mainly on the controlling of the percent of PEG4000 and GMS during the preparation of fusion complex.…”