A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

Arshad, Muhammad Sohail; Zafar, Saman; Yousef, Bushra; Alyassin, Yasmine; Ali, Radeyah; Alasiri, Ali; Chang, Ming‐Wei; Ahmad, Zeeshan; Elkordy, Amal; Faheem, Ahmed; Pitt, Kendal

doi:10.1016/j.addr.2021.113840

Cited by 61 publications

(21 citation statements)

References 238 publications

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“…Conventionally, quality control (QC) tests used in large-scale manufacturing processes on Earth aim to establish shelf-life and identify by-products by accelerating abiotic degradation processes, such as hydrolysis, oxidation and photolysis ( EMA, 2003 ). Analysis typically involves multiple techniques including gas chromatography – mass spectrometry (GC/MS), infra-red spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and elemental analysis techniques ( Sohail Arshad et al, 2021 ). These help to identify the presence of any impurities, such as heavy metals and leachable, and degradation products due to drug instability.…”

Section: Ensuring Efficacy and Safety: On-site Drug Analysismentioning

confidence: 99%

To infinity and beyond: Strategies for fabricating medicines in outer space

Seoane-Viaño¹,

Ong²,

Basit³

et al. 2022

International Journal of Pharmaceutics: X

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Section: Ensuring Efficacy and Safety: On-site Drug Analysismentioning

confidence: 99%

To infinity and beyond: Strategies for fabricating medicines in outer space

Seoane-Viaño¹,

Ong²,

Basit³

et al. 2022

International Journal of Pharmaceutics: X

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“…In the pharmaceutical industry, solid dosage forms are most commonly prescribed and preferred by most medical practitioners, due to their accurate dosing, superior stability, and high precision [ 22 , 23 ]. For instance, the Therapeutic Goods Administration (TGA), Australia approved 59 solid dosage form products in October 2015 containing A. paniculata [ 24 ].…”

Section: Conventional Dosage Formsmentioning

confidence: 99%

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview

2022

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Andrographis paniculata is a well-known Asian medicinal plant with a major phytoconstituent of diterpene lactones, such as andrographolide, 14-deoxyandrographolide, and neoandrographolide. A World Health Organization (WHO) monograph on selected medicinal plants showed that A. paniculata extracts and its major diterpene lactones have promising anti-inflammatory, antidiabetic, antimalarial, anticancer, antifungal, antibacterial, antioxidant, and hypoglycemic activities. However, these active phytochemicals have poor water solubility and bioavailability when delivered in a conventional dosage form. These biological barriers can be mitigated if the extract or isolated compound are delivered as nanoparticles. This review discusses existing studies and marketed products of A. paniculata in solid, liquid, semi-solid, and gaseous dosage forms, either as an extract or isolated pure compounds, as well as their deficits in reaching maximum bioavailability. The pharmaceutics and pharmacological activity of A. paniculata as a nano-delivery system are also discussed.

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“…In addition, the synergistic use of shellac and other functional excipients, such as taste-masking agents, dissolution enhancers, release-rate modifiers, and mucosal adhesives, may also add specific properties to shellac-based matrix tablets. Thus, shellac-based coprocessed excipients and ready-to-use excipients that can be used for continuous manufacturing need to be further developed to expand the application and market value of shellac-based matrix tablets . Advanced technologies also need to be introduced for the further development of shellac-based matrix tablets.…”

Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

“…Thus, shellac-based coprocessed excipients and ready-to-use excipients that can be used for continuous manufacturing need to be further developed to expand the application and market value of shellac-based matrix tablets. 92 Advanced technologies also need to be introduced for the further development of shellacbased matrix tablets. Three-dimensional (3D) printing technology has become a popular additive manufacturing technology in recent years.…”

Section: Shellac-based Delivery Systemsmentioning

confidence: 99%

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

Yuan

Dong

et al. 2021

ACS Nano

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Delivery systems play a crucial role in enhancing the activity of active substances; however, they require complex processing techniques and raw material design to achieve the desired properties. In this regard, raw materials that can be easily processed for different delivery systems are garnering attention. Among these raw materials, shellac, which is the only pharmaceutically used resin of animal origin, has been widely used in the development of various delivery systems owing to its pH responsiveness, biocompatibility, and degradability. Notably, shellac performs better on encapsulating hydrophobic active substances than other natural polymers, such as polysaccharides and proteins. In addition, specially designed shellac-based delivery systems can also be used for the codelivery of hydrophilic and hydrophobic active substances. Shellac is most widely used for oral administration, as shellac-based delivery systems can form a compact structure through hydrophobic interaction, protecting transported active substances from the harsh environment of the stomach to achieve targeted delivery in the small intestine or colon. In this review, the advantages of shellac in delivery systems are discussed in detail. Multiscale shellac-based delivery systems from the macroscale to nanoscale are comprehensively introduced, including matrix tablets, films, enteric coatings, hydrogels, microcapsules, microparticles (beads/spheres), nanoparticles, and nanofibers. Furthermore, the hotspots, deficiencies, and future perspectives of shellac-based delivery system development are also analyzed. We hoped this review will increase the understanding of shellac-based delivery systems and inspire their further development.

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A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

Cited by 61 publications

References 238 publications

To infinity and beyond: Strategies for fabricating medicines in outer space

To infinity and beyond: Strategies for fabricating medicines in outer space

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview

Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale

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