Dissolution of a Soluble Drug Substance from Vinyl Polymer Matrices

Brossard, C.; Ylouses, D. Lefort Des; Duchêne, Dominique; Puisieux, F.; Carstensen, J.T.

doi:10.1002/jps.2600720217

Cited by 42 publications

(4 citation statements)

References 44 publications

(18 reference statements)

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“…The latter should result in decreased theophylline release. Other factors which modify drug release in matrix systems are solubility of the drug (Brossard et al, 1983;Saha et al, 2001;Jambhekar et al, 1987) and formulation additives (Khan and Zhu, 1999;Rohera and Parikh, 2002;Tang et al, 2000). The dissolution profiles of theophylline capsules are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Use of dika fat in the formulation of sustained release theophylline tablets and capsules

Umekoli¹,

Onyechi²,

Udeala³

2009

Bio-Research

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Sustained release theophylline tablets and capsules were prepared with dika fat, a solid vegetable oil extracted from the kernels of Irvingia gabonesis var gabonesis and var excelsia. Anhydrous theophylline was incorporated into dika fat by the fusion method. The in vitro release of the theophylline was monitored by the so-called half change dissolution method in stimulated gastric juice USP without pepsin and in stimulated intestinal juice without pancreatin, respectively. The USP XX paddle method was used. A level of sustained release was achieved over a 6-h period in both the tabletted and encapsulated dosage forms. The theophylline formulations containing dika fat, prepared in this study, exhibited dissolution profiles similar to those of Theo 24, Theodur and Respid, some commercial sustained release theophylline formulations.

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Section: Resultsmentioning

confidence: 99%

Use of dika fat in the formulation of sustained release theophylline tablets and capsules

Umekoli¹,

Onyechi²,

Udeala³

2009

Bio-Research

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“…This non-speci® c model allows the characterization of erodible matrices, particularly drug release kinetics from enteric polymers presenting a pH-dependent solubility, such as HP 50 (Brossard et al 1983, Brossard andWouessidjewe 1990). More than 80% of the drug was released after 30 min from beads containing precipitated nimesulide (® gure 5), indicating that these preparations comply with the USP XXIII limit for enteric formulations (Q > 75%, 45 min).…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method

Cerdeira

Gouveia

Goucha³

et al. 2000

Journal of Microencapsulation

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The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads could only be obtained after size reduction of nimesulide crystals. This is confirmed by the angle of repose measurements, which show a significant decrease in theta values when beads are formulated with smaller drug particles. Furthermore, results show that drug encapsulation efficiency and in vitro drug release rates are also greatly dependent on both drug particle size and drug/polymer ratio in the initial suspension. Preparations containing 10.2 microm drug particles show a two-fold increase in the release rates when compared to those prepared with 40 microm particles.

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“…The first is immediately evident when drug at the surface of the tablet dissolves and diffuses away. As the hydrophilic polymer takes up water, swelling might cause pieces of material to erode or dissolve away from the surface of the tablet (47). With erosion, more surfaces are created for ready drug dissolution and the resulting diffusion pathlength of the remaining tablet and its pieces becomes shorter with time.…”

Section: Mathematical Modeling Of Drug Release Profilesmentioning

confidence: 99%

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

2010

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Abstract. The objectives were to characterize propranolol hydrochloride-loaded matrix tablets using guar gum, xanthan gum, and hydroxypropylmethylcellulose (HPMC) as rate-retarding polymers. Tablets were prepared by wet granulation using these polymers alone and in combination, and physical properties of the granules and tablets were studied. Drug release was evaluated in simulated gastric and intestinal media. Rugged tablets with appropriate physical properties were obtained. Empirical and semi-empirical models were fit to release data to elucidate release mechanisms. Guar gum alone was unable to control drug release until a 1:3 drug/gum ratio, where the release pattern matched a Higuchi profile. Matrix tablets incorporating HPMC provided near zero-order release over 12 h and erosion was a contributing mechanism. Combinations of HPMC with guar or xanthan gum resulted in a Higuchi release profile, revealing the dominance of the high viscosity gel formed by HPMC. As the single rate-retarding polymer, xanthan gum retarded release over 24 h and the Higuchi model best fit the data. When mixed with guar gum, at 10% or 20% xanthan levels, xanthan gum was unable to control release. However, tablets containing 30% guar gum and 30% xanthan gum behaved as if xanthan gum was the sole rate-retarding gum and drug was released by Fickian diffusion. Release profiles from certain tablets match 12-h literature profiles and the 24-h profile of Inderal ® LA. The results confirm that guar gum, xanthan gum, and HPMC can be used for the successful preparation of sustained release oral propranolol hydrochoride tablets.

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Dissolution of a Soluble Drug Substance from Vinyl Polymer Matrices

Cited by 42 publications

References 44 publications

Use of dika fat in the formulation of sustained release theophylline tablets and capsules

Use of dika fat in the formulation of sustained release theophylline tablets and capsules

Drug particle size influence on enteric beads produced by a droplet extrusion/precipitation method

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

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