Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

Mughal, Muhammad Akhlaq; Iqbal, Zafar; Neau, Steven H.

doi:10.1208/s12249-010-9570-1

Cited by 54 publications

(25 citation statements)

References 51 publications

(79 reference statements)

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“…The decreased drug release is due to increased retarding efficiency of HPMC E 15LV and PVP K 30 in combination, i.e., synergistic effect was observed. It has been reported that HPMC with low viscosity grades also shows maximum release retarding efficiency in tablets containing 20-50% (Mughal et al, 2011).…”

Section: In-vitro Drug Release Profilementioning

confidence: 99%

“…The initial burst release was seen with xanthan gum because it can hydrate rapidly even in cold water. It is highly swellable and showed sustained release (Mughal et al, 2011;Singh et al, 2011).…”

Section: In-vitro Drug Release Profilementioning

confidence: 99%

“…The highest swelling index (70.39% for 8 hours) was seen with HPMC E 15LV and PVP K30 in 5%. The reason for increased swelling index of HPMC E 15LV is due to high degree of erosion and low viscosity which makes the tablet to swell (Mughal et al, 2011;Singh et al, 2011).…”

Section: Swelling Indexmentioning

confidence: 99%

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Novel core in cup (In-lay) tablets of lamotrigine for mucoadhesive drug delivery system

Srinija

Lakshmi

2016

Int Curr Pharm J

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Lamotrigine a BCS class II drug used in treatment of epilepsy has several disadvantages when taken orally (first pass metabolism and increased Cmax). The aim of the study is to design core in cup (In lay) buccoadhesive tablets which aims for controlled, unidirectional release, increased patient compliance and decreased side effects. The present study involves the preparation of core in cup tablets containing release retarding polymers like sodium alginate, xanthan gum and HPMC E 15LV in core and HPMC K 15M in cup for mucoadhesion. L9 orthogonal array Taguchi design was constructed for the study. The dependent variable studied for L9 orthogonal array Taguchi runs include % drug release from which the formulation with highest S/N ratio was optimized. All the runs were evaluated for physical parameters, drug release, mucoadhesive studies and assay. L1, L2, L4 and L8 formulations showed controlled release for up-to 8 hours with good assay values. The model dependent kinetics showed zero order kinetics with super case II transport and Hixson Crowell mechanism which indicates unidirectional drug release.Srinija and Lakshmi, International Current Pharmaceutical Journal, January 2016, 5(2): 9-13

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Section: In-vitro Drug Release Profilementioning

confidence: 99%

Section: In-vitro Drug Release Profilementioning

confidence: 99%

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Novel core in cup (In-lay) tablets of lamotrigine for mucoadhesive drug delivery system

Srinija

Lakshmi

2016

Int Curr Pharm J

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“…Such interaction leads to the formation of viscous polymer solution around the tablet surface (23,24). Release of drug from a hydrophilic matrix tablet depends on the viscosity of the swollen region that in turn is a function of the amount of polymer in the matrix (15). Since FX1 tablet was composed of 90% CMXG, a highly viscous polymer solution having considerable mechanical strength was formed around the tablet surface that acted as a barrier to diffusion of drug.…”

Section: Drug Releasementioning

confidence: 99%

“…Most of the investigations related to XG, either alone or in combination with other polymers, involved design of sustained-release matrix tablets (12)(13)(14)(15). However, there is no report on release pattern of a drug from derivatized and cross-linked XG matrix.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Ca+ 2 Ion Cross-Linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique

Maity

2014

AAPS PharmSciTech

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Abstract. The objective of this work was to study the release behavior of prednisolone from calcium-crosslinked carboxymethyl xanthan gum (CMXG) tablets in dissolution medium having different pH values prevailing in the gastrointestinal lumen. Xanthan gum (XG) was derivatized to CMXG which was then cross-linked in situ with Ca +2 ion during wet massing step of tablet preparation. Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry studies did not show any drug-polymer interaction although the drug underwent solid-state transformation during compression as evident from X-ray diffraction analysis. In vitro release study demonstrated that increase in the amount of Ca +2 ion decreased the drug release, and beyond a certain amount, the drug release increased. While increase in both drug load and tablet crushing strength decreased the drug release, increase in exposure time in acid solution of pH 1.2 increased the overall release of the drug. The mechanism of drug release was nonFickian/anomalous. The results indicated that variation in the amount of Ca +2 ion can modulate the drug release from CMXG matrix tablets as needed.

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Xanthan gum: A versatile biopolymer for biomedical and technological applications

Petri

2015

J of Applied Polymer Sci

316

189

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Xanthan gum is an extracellular polymer produced mainly by the bacterium Xanthomonas campestris. Traditionally it plays an important role in industrial applications as thickener, emulsion stabilizer and it has been added to water-based drilling fluids due to its pseudoplastic behavior and thermal stability. The structural properties of xanthan in solution can be tuned by the temperature and ionic strength; under high ionic strength or low temperature, xanthan chains are arranged in helical conformation, whereas under low ionic strength or high temperature, xanthan chains are coiled. Xanthan high molecular weight favors the building up of physical and chemical networks, which have been used as carriers for drugs and proteins and as scaffolds for cells. In combination with other polymers xanthan has been applied as excipient in tablets or as supporting hydrogels for drug release applications, particularly due to its acid resistance. The large versatility of xanthan gum opens the possibility for the creation of new architectures and additional applications involving this fascinating polymer. AIMSThe purpose of this review is to report on the applications of xanthan gum in biomedical and technological products over the last ten years, but revisiting the background and the highlights of traditional applications as thickener. The in vivo biodegradability and biocompatibility of xanthan gum are fundamental characteristics that allow its use in biomedical applications. The ability to form networks and acid resistance make xanthan gum, as pure excipient or in combination with other polymers, very attractive as drug carriers. The recent combinations with inorganic particles open a range of new applications.

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Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

Cited by 54 publications

References 51 publications

Novel core in cup (In-lay) tablets of lamotrigine for mucoadhesive drug delivery system

Novel core in cup (In-lay) tablets of lamotrigine for mucoadhesive drug delivery system

Development and Evaluation of Ca+ 2 Ion Cross-Linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique

Xanthan gum: A versatile biopolymer for biomedical and technological applications

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