Suspected drug‐induced destructive cholangitis in a young dog

Gabriel, Annick; Ingh, T. S. G. A. M. van den; Clercx, Cécile; Peeters, Dominique

doi:10.1111/j.1748-5827.2006.00155.x

Cited by 9 publications

(14 citation statements)

References 19 publications

(45 reference statements)

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“…The etiology of destructive cholangitis is not fully understood in animals, although drug-induced toxicity, infection and idiopathic processes have been considered responsible [2,5,11]. The present case had no history of medication, accidental ingestion of drugs or chemicals and no evidence of CDV infection.…”

mentioning

confidence: 85%

“…Destructive cholangitis in dogs reportedly shows a poor prognosis, with most cases in previous studies euthanized due to a lack of response to treatment [5,11]. In a report of 7 dogs treated with prednisolone and ampicillin [11], only 1 dog recovered and survived.…”

mentioning

confidence: 99%

“…Clinical cases of destructive cholangitis have been described in dogs [5,11]. Although the causes of this disease in dogs remain unclear and many cases are idiopathic, drugs such as sulfonamides and infection by canine distemper virus (CDV) are thought to be responsible for the disease [5,11].…”

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confidence: 99%

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A Case of Recovery from Canine Destructive Cholangitis in a Miniature Dachshund

Osumi

Ohno

Kanemoto

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. A 7-year-old Miniature Dachshund presented with severe chronic jaundice and elevated liver enzymes. Destructive cholangitis was diagnosed according to histopathological findings of remarkable ductopenia with inflammatory infiltrates and fibrosis in the portal areas. Supportive therapy with prednisolone, high-dose ursodeoxycholic acid, human placental extract and antibiotics was tried, and the patient showed recovery of clinical signs 3 months after diagnosis. A second liver biopsy was performed about 1 year after initial diagnosis, and bile duct restoration was confirmed with continuous inflammation around portal areas and inside the lobules. Although we could not determine which treatment was effective in this case, destructive cholangitis in dogs may be recoverable with long-term supportive therapies.

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confidence: 99%

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A Case of Recovery from Canine Destructive Cholangitis in a Miniature Dachshund

Osumi

Ohno

Kanemoto

et al. 2011

The Journal of Veterinary Medical Science

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“…Destructive cholangitis, characterized by loss of bile ducts with accompanying inflammation, also can lead to biliary fibrosis . Idiosyncratic drug reactions have been implicated in causing this uncommon disease …”

Section: Causes Of Hepatic Fibrosis In Dogsmentioning

confidence: 99%

Hepatic Fibrosis in Dogs

Eulenberg

Lidbury

2017

Veterinary Internal Medicne

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Hepatic fibrosis is commonly diagnosed in dogs, often as a sequela to chronic hepatitis (CH). The development of fibrosis is a crucial event in the progression of hepatic disease that is of prognostic value. The pathophysiology of hepatic fibrosis in human patients and rodent models has been studied extensively. Although less is known about this process in dogs, evidence suggests that fibrogenic mechanisms are similar between species and that activation of hepatic stellate cells is a key step. Diagnosis and staging of hepatic fibrosis in dogs requires histopathological examination of a liver biopsy specimen. However, performing a liver biopsy is invasive and assessment of fibrotic stage is complicated by the absence of a universally accepted staging scheme in veterinary medicine. Serum biomarkers that can discriminate among different fibrosis stages are used in human patients, but such markers must be more completely evaluated in dogs before clinical use. When successful treatment of its underlying cause is feasible, reversal of hepatic fibrosis has been shown to be possible in rodent models and human patients. Reversal of fibrosis has not been well documented in dogs, but successful treatment of CH is possible. In human medicine, better understanding of the pathomechanisms of hepatic fibrosis is leading to the development of novel treatment strategies. In time, these may be applied to dogs. This article comparatively reviews the pathogenesis of hepatic fibrosis, its diagnosis, and its treatment in dogs.

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“…The pathogenesis of bile-duct loss includes immunological, infectious, ischemic, and toxic factors [4]. On the other hand, bile-duct loss is rarely reported in dogs [5,6]. The present paper describes the clinical and histopathological characteristics of destructive cholangitis in a canine.…”

Section: Introductionmentioning

confidence: 99%

Destructive Cholangitis in an Adult Jack Russell Terrier

Kodama

Sakai

Kimura

et al. 2012

Case Reports in Veterinary Medicine

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A 4-year-old female Jack Russell terrier dog exhibited vomiting and severe jaundice of the visible mucous membranes and skin. Ultrasonography revealed diffuse areas of high echogenicity and focal areas of low echogenicity in the left lobe of the liver. On macroscopic observation of the biopsied liver specimen, many scattered irregularly shaped red spots were observed on the liver surface and on the cut surface. Histopathologically, there was loss of the interlobular bile duct and cholangitis accompanied by infiltration of pigment-laden macrophages in the Glisson's capsule. Therefore, in the present case the dog was diagnosed with destructive cholangitis.

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Suspected drug‐induced destructive cholangitis in a young dog

Cited by 9 publications

References 19 publications

A Case of Recovery from Canine Destructive Cholangitis in a Miniature Dachshund

A Case of Recovery from Canine Destructive Cholangitis in a Miniature Dachshund

Hepatic Fibrosis in Dogs

Destructive Cholangitis in an Adult Jack Russell Terrier

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