In this study the clinico-pathological aspects of cutaneous and mucocutaneous plasmacytomas were investigated in 63 dogs (one dog with two tumours). The tumours were most commonly observed in the skin of the trunk and legs. Yorkshire Terrier (n = 8) was the most commonly affected breed and males were affected more commonly than females (36 versus 23, respectively). Plasmacytomas were histologically classified into mature, hyaline, cleaved, asynchronous, monomorphous blastic and polymorphous blastic cell types. Monomorphous blastic cell type was the most frequent type (n = 21), followed by cleaved (n = 19) and asynchronous (n = 11) cell types. Secondary amyloid depositions were observed in eight cases. Immunohistochemical staining showed monoclonal lambda light chain positivity in all cases. In the immunohistochemical staining for cyclin D1, which is a prognostic marker in human plasma cell tumours, moderate numbers of positive tumour cells were observed in only one case of (muco)cutaneous plasmacytoma. All other cases were negative or contained few positive tumour cells. On the other hand, high numbers of tumorous plasma cells reacted positively with cyclin D1 in three out of six cases of canine multiple myelomas. Prognosis of the (muco)cutaneous plasmacytomas was good, except in one dog which developed a lymphoma afterwards. No significant correlations were observed between the cell type and the location of the tumour, presence of amyloid or prognosis.

Background: Hydrolyzed protein diets are commonly used to manage canine chronic enteropathies (CE), but their efficacy has not yet been critically evaluated.Hypothesis: A hydrolyzed protein diet is superior to that of a highly digestible (control) diet in the management of CE in dogs.Animals: Twenty-six dogs (18 test diet, 8 control diet) referred for investigation and management of naturally occurring chronic small intestinal disease.Methods: Randomized, open-label, positively controlled trial. After a full diagnostic investigation, which included endoscopy, dogs were assigned either to the test diet or control diet on a 2 : 1 basis (test : control). Cases were re-evaluated 3 times (at approximately 3, 6-12 months, and 3 years). Outcome measures included response of clinical signs (complete, partial, none), change in severity of signs (based upon clinical disease activity index; canine inflammatory bowel disease activity index [CIBDAI]), change in body weight, and need for other therapy.Results: There were no significant differences in baseline characteristics (eg, signalment, body weight, and duration of clinical signs), and histopathologic severity between test and control diet groups. However, despite randomization, CIBDAI was significantly higher in the test diet group (P 5 .013). Most dogs had responded by first evaluation, with no difference between groups (P 5 .87). However, significantly more dogs on the test diet remained asymptomatic at both the second (P 5 .0012) and third (P o .001) re-evaluation, and the decrease in CIBDAI was significantly greater (P 5 .010).Conclusions and Clinical Importance: A hydrolyzed protein diet can be highly effective for long-term management of canine chronic small bowel enteropathy.

Summary One hundred and thirty nine canine perineal tumours were histologically evaluated. The vast majority (134 tumours = 96.4%) appeared to originate from the characteristic glandular structures of this region. They were classified as well differentiated perianal gland tumours (58.3%), as moderately or poorly differentiated perianal gland tumours (21.6%) and as carcinomas without perianal gland differentiation (16.5%). Only 5 tumours (3.6%) appeared to originate from non‐characteristic perineal structures. A prominent male predominance was found with respect to the perianal gland tumours, whereas the carcinomas showed a distinct female predisposition. Tumours showing perianal gland differentiation almost invariably will have a benign behaviour. The carcinomas lacking any perianal gland differentiation often show a distinct malignant behaviour with metastases to regional lymph nodes and internal organs. These malignant neoplasms showed morphological and clinical features comparable to canine anal sac gland adenocarcinomas and carcinoids in man and animals. Zusammenfassung Tumore des Perineums beim Hund Einhundertneununddreißig Tumore des Perineums wurden beim Hund histologisch ausgewertet. Die große Mehrheit (134 Tumoren = 96,4%) schien sich von den Drüsenstrukturen dieses Areals abzuleiten. Sie wurden als gut differenzierte Tumore der Perianaldrüsen (58,3%), mäßig oder wenig differenzierte Tumore der Perianaldrüsen (21,6%) und als Carcinome ohne Perianaldrüsen‐Differenzierung (16,5%) klassifiziert. Nur 5 Tumore (3,6%) schienen sich von nicht charakteristischen perinealen Strukturen herzuleiten. Für die Perianaldrüsen‐Tumore ergab sich beim männlichen Geschlecht eindeutig eine Dominanz, während sich für die Carcinome beim weiblichen Geschlecht eine Prädisposition zeigte. Tumore mit einer Perianaldrüsen‐Differenzierung erweisen sich im allgemeinen als gutartig. Die Carcinome ohne Perianaldrüsen‐Differenzierung zeigen oft ein ausgeprägtes bösartiges Verhalten mit Metastasen in den regionalen Lymphknoten und inneren Organen. Diese malignen Neoplasmen wiesen Merkmale auf, die mit denjenigen von Adenocarcinomen der Analbeuteldrüsen beim Hund und der Carcinoide beim Menschen und bei Tieren vergleichbar sind.

Congenital porto‐systemic shunts in sixteen dogs and three cats are described. A major symptom was hepato‐encephalopathy. In most cases diagnosis was based on elevated venous ammonia levels, abnormal ammonia tolerance and results of operative mesenteric portography. Clinical signs, laboratory findings, results of portography, and pathologic findings in the liver and the central nervous system are described. A diagnostic schedule is proposed to aid in recognition of this syndrome.

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