Surveys of knowledge and awareness of antibiotic use and antimicrobial resistance in general population: A systematic review

Kosiyaporn, Hathairat; Chanvatik, Sunicha; Issaramalai, Tibet; Kaewkhankhaeng, Wanwisa; Kulthanmanusorn, Anond; Saengruang, Nithiwat; Witthayapipopsakul, Woranan; Viriyathorn, Shaheda; Kirivan, Supapat; Kunpeuk, Watinee; Suphanchaimat, Rapeepong; Lekagul, Angkana; Tangcharoensathien, Viroj

doi:10.1371/journal.pone.0227973

Cited by 43 publications

(29 citation statements)

References 24 publications

(158 reference statements)

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“…To-date none of the studies that measured the association of Knowledge and Attitudes with Practices of use of antibiotics in the general population applied a fully validated questionnaire 8 . Therefore, to fill this gap, we designed and validated the psychometric properties of a KAP questionnaire about antibiotics’ use by the adult general population.…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, despite the long-standing recognition of antibiotic resistance, the literature revealed that to-date, no fully validated KAP questionnaire is available for antibiotics’ use by the general population 7 . A recent systematic review of surveys about knowledge and/or attitudes towards antibiotic use by the general population reported that 11 studies tested the validity and the reliability of the used questionnaire 8 , but the validity of these questionnaires was only partially assessed and limited to face and/or content validity. Other studies claimed using “previously similar validated questionnaires” 9 , nonetheless the cited studies were not found to include validated questionnaires.…”

Section: Introductionmentioning

confidence: 99%

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Design, reliability and construct validity of a Knowledge, Attitude and Practice questionnaire on personal use of antibiotics in Spain

Mallah

Rodríguez‐Cano

Figueiras

et al. 2020

Sci Rep

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Numerous questionnaires are available on Knowledge, Attitudes, and Practices (KAP) towards antibiotics' use by adults, but none of these questionnaires is fully validated. We undertook an exhaustive literature review to design a comprehensive KAP questionnaire concerning the personal use of antibiotics in Galicia, North Spain. The Item Content Validity Index (I-CVI) and modified Kappa statistic (K*), confirmed the content validity of the questions (0.78 ≤ I-CVI ≤ 1.00 and 0.78 ≤ K* ≤ 1.00). The S-CVI statistic showed the content validity of the scale (S-CVI/Ave: 0.95). Following face validity and pilot testing, the Test–Retest Reliability in a sample of 145 adults confirmed the reliability of the questions. We carried out Confirmatory Factor Analysis using cross loadings and modification indices to choose the most adequate model in data collected from 844 adults. We estimated the indicators of model fit and demonstrated that the selected model has a good to excellent fit, thus establishing the construct validity. The final version of the questionnaire was highly accepted by the general adult population as reflected by the response rate (95.85%) and the low percentage of unanswered questions (0.4–2.7%). Our fully validated questionnaire could prove useful for research as it permits generating high quality data and reducing measurement error.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design, reliability and construct validity of a Knowledge, Attitude and Practice questionnaire on personal use of antibiotics in Spain

Mallah

Rodríguez‐Cano

Figueiras

et al. 2020

Sci Rep

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“…To our knowledge, there are very few studies on the antimicrobial effect of pure single OA or NIC against Vibrio , and they do not cover the wide panel of bioactives screened in this study. Although chemotherapy has been widely used to prevent and treat disease outbreaks [ 29 ] up until now, the AMR threats, as well as the increasing consumer awareness of the need to reduce antibiotic usage [ 30 ], are leading to a worldwide effort to change toward more sustainable aquaculture production methods. In terrestrial livestock, OA and botanicals are two of the most interesting antimicrobial alternatives to antibiotics [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Power of Organic Acids and Nature-Identical Compounds against Two Vibrio spp.: An In Vitro Study

Rossi¹,

Esteban

Beltrán

et al. 2021

Microorganisms

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Vibrosis is one of the major threats in aquaculture farming, and due to the increasing antimicrobial resistance of different Vibrio species, there is an urgent need to replace conventional treatments with more sustainable solutions. Antimicrobial molecules such as organic acids (OA) and nature-identical compounds (NIC) are currently finding a central role in the infection management of terrestrial livestock, but little is known about their usage in aquaculture. The aim of this study was to perform a preliminary screening of the in vitro antimicrobial activity of a wide panel of OA and NIC against 2 Vibrio species characteristic of the Mediterranean area, Vibrio harveyi and Vibrio anguillarum, through minimal inhibitory/bactericidal concentration tests. The active principles that showed the best effective pathogen control were medium-chain fatty acids, sorbic and benzoic acid among OA and phenolic monoterpenoids (thymol, carvacrol and eugenol) and aromatic monoterpene aldehydes (vanillin and cinnamaldehyde) among NIC. These results showed how the usage of OA and NIC can open promising perspectives in terms of Vibrio spp. load control in aquaculture. Natural or nature-identical feed additives can make aquaculture production not only more efficient by reducing the need for medicated treatments, but also more sustainable.

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“…15 A recent systematic review done from the low-and middleincome countries and a few studies from the developed countries like from Australia, Italy, North Carolina have revealed knowledge gaps concerning antibiotic use among general population. [16][17][18][19] These studies have indicated that the behavior of the general population is skewed towards the random use of antibiotics. These behaviors are prevalent in many LMICs -driven by the trend that antibiotics can be purchased as OTC from retail pharmacies.…”

Section: Introductionmentioning

confidence: 99%

Knowledge and behavior of consumers towards the non-prescription purchase of antibiotics: An insight from a qualitative study from New Delhi, India

Kotwani

Joshi

Lamkang

et al. 2021

Pharm Pract (Granada)

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Background: In Low-and Middle-Income Countries, including India, consumers often purchase antibiotics over-the-counter (OTC) from retail pharmacies. This practice leads to the inappropriate use of antibiotics in the community which is an important driver for the development of antimicrobial resistance. A better understanding of consumers’ views towards this grave public health concern is critical to developing evidence-based intervention programs for awareness among the general population. Objective: To explore knowledge, practice and, behavior of consumers towards antibiotics, antibiotic use, antimicrobial resistance, purchasing behavior of consumers for antibiotics, and to gain insight which will help in developing evidence-based policy interventions. Methods: 72 in-depth consumer interviews were conducted in all 11 districts of the National Capital Territory of Delhi. The qualitative data were analyzed using thematic analysis. Results: Our study found that retail pharmacies were the first point of consultation for common ailments for patients/consumers once home remedies failed; they were largely unaware of the threat of antimicrobial resistance. Consumers’ knowledge of antibiotic use and about antimicrobial resistance was low, they used old prescriptions, and bought antibiotics OTC to save time and money. Despite the presence of regulations constituted to regulate the sale of antibiotics by the Government and the implementation of national campaigns, the practice of self-medication and behaviors such as OTC purchase, non-adherence to prescribed antibiotics was prevalent. Consumers perceive that antibiotics provide quick relief and accelerate the curing process and retail pharmacy shops try to protect their retail business interests by honoring old prescriptions and self-medication for antibiotics. Conclusions: The lack of awareness and insufficient knowledge about what antibiotics are and issues such as antimicrobial resistance or antibiotic resistance resulted in misuse of antibiotics by consumers. Limited access to public healthcare and affordability of private healthcare are factors that contribute towards the self-medication/OTC purchase of antibiotics. The regular misuse of antibiotics through irrational use reinforces the need for strong enactment of strategies like continuous community awareness campaigns. Mitigation efforts should focus upon educating consumers continuously and sustainably for the understanding of antibiotic misuse, antimicrobial resistance, and promote better compliance with regulations.

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Surveys of knowledge and awareness of antibiotic use and antimicrobial resistance in general population: A systematic review

Cited by 43 publications

References 24 publications

Design, reliability and construct validity of a Knowledge, Attitude and Practice questionnaire on personal use of antibiotics in Spain

Design, reliability and construct validity of a Knowledge, Attitude and Practice questionnaire on personal use of antibiotics in Spain

Antimicrobial Power of Organic Acids and Nature-Identical Compounds against Two Vibrio spp.: An In Vitro Study

Knowledge and behavior of consumers towards the non-prescription purchase of antibiotics: An insight from a qualitative study from New Delhi, India

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