Survey of intraocular lens material and design

Abstract

Modern cataract surgery is constantly evolving and improving in terms of lens material and design. Researchers and physicians strive to obtain better refractive correction with smaller wound size and minimizing host cell response to limit the proliferation of lens epithelial cells leading to opacification of the lens capsule. Intraocular lens material varies in water content, refractive index, and tensile strength. Intraocular lens design has undergone revisions to prohibit lens epithelial cell migration and reflection of internal and external light. The evolution of intraocular lens and extracapsular cataract surgery has lead to faster postoperative recovery and better visual outcomes.

Anti-infective photodynamic biomaterials for the prevention of intraocular lens-associated infectious endophthalmitis

“…Colonization of IOLs by bacteria such as Staphylococcus epidermidis, the microorganism most frequently responsible for cases of acute endophthalmitis [7,8], eventually leads to the production of a microbial biofilm on the surface of the IOL [9,10]. IOLs may be manufactured using a range of different polymeric materials including polymethyl methacrylate, copolymers of acrylate and methacrylate or elastomers of polysiloxane [11]. This study employs methacrylate copolymers as the putative IOL material due to the excellent biocompatibility of hydrophilic acrylic IOLs.…”

Control of cell adhesion on poly(methyl methacrylate)

“…However, failure due to poor adhesion between the implant and the host corneal collagen at the implant-host interface as well as fibrous membrane development due to fibroblast attachment over the inner surface of the implant remain significant and persistent problems [6][7][8]. Surface modifications of PMMA with poly(ethylene glycol) (PEG) have been shown to block cell adhesion [9].…”

Traumatic fracture of posterior chamber intraocular lens

“…It is durable and resistant to changes caused by aging and climate. 1 Polymethylmethacrylate is still the standard intraocular lens (IOL) material against which newer materials are compared. The material has good tensile strength.…”