Control of cell adhesion on poly(methyl methacrylate)

Patel, Shyam; Thakar, Rahul; Wong, Josh; McLeod, Stephen D.; Song, Li

doi:10.1016/j.biomaterials.2005.12.009

Cited by 93 publications

(85 citation statements)

References 14 publications

(15 reference statements)

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“…26,27 Results and Discussion Design. The promotion of cellular adhesion on biocompatible polymer substrates is generally achieved either by coating the materials with ECM proteins and RGD-containing large peptides 20 or by surface derivatization with small (cyclic) RGD peptides 28,29 and peptidomimetics (i.e., nonpeptide mimics of the RGD sequence constrained in the bioactive conformation). This latter approach is quite underemployed from the literature, 25 most probably because it requires expertise and consistent efforts in organic synthesis.…”

Section: Introductionmentioning

confidence: 99%

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

et al. 2009

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RGD peptides are used in biomaterials science for surface modifications with a view to elicit selective cellular responses. Our objective is to replace peptides by small peptidomimetics acting similarly. We designed novel molecules targeting R v β 3 integrin and featuring spacer-arms (for surface grafting), which do not disturb the biological activity, from (L) N-(3-(trifluoromethyl)benzenesulfonyl) tyrosine used as scaffold. Various Arg-mimics were fixed on the phenol function, and the ortho position was used for the coupling of OEG spacers. All peptidomimetics were active in the nM range in a binding test toward human R v β 3 integrin (IC 50 = 0.1 to 1.7 nM) and selective versus platelet integrin R IIb β 3 . Selected compounds revealed excellent ability to inhibit bone cells adhesion on vitronectin. Modeling and docking studies were performed for comparing the most active RGD peptidomimetic to cilengitide, i.e., cyclo-[RGDfN(Me)V]-. Lastly, the adhesion of endothelial cells on a cultivation support grafted with RGD peptidomimetics was significantly improved.

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Section: Introductionmentioning

confidence: 99%

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

et al. 2009

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“…First, the versatility toward a large variety of monomers and polymer architectures enables synthesis of adaptable ground for cell adhesion/proliferation and for the establishment of important biological processes like angiogenesis. Moreover, it is possible to produce low-molecular-weight building blocks more easily excreted out of the body and site-specific functionalized polymer chains like well-defined bioconjugates (for instance RGD peptide/polymer conjugates [135]). …”

Section: Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Toward New Materials Prepared via the RAFT Process: From Drug Delivery to Optoelectronics?

Favier

Lambert

Charreyre

2008

Handbook of RAFT Polymerization

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IntroductionThe development of controlled/living ionic and radical polymerization techniques during the last decades represents a major breakthrough in polymer chemistry and polymer science. Since these techniques lead to the synthesis of a wide range of tailor-made macromolecular architectures, significant improvements are expected in the current or future application fields of polymers. The industrial impact will however depend on the versatility and applicability of each technique, and of course on the extra cost for the final product.In this context, controlled radical polymerizations (CRP) and especially the reversible addition-fragmentation chain transfer (RAFT) process [1-3] have attracted a lot of attention since they combine the advantages of conventional radical polymerization and living ionic polymerizations. Conventional radical polymerizations are cost-effective techniques, easy to process with a low sensitivity to water and oxygen and applicable to a wide range of monomers. In addition, CRP techniques result in a very efficient control over molecular weight (MW), molecular-weight distribution (MWD), microstructure, chain-end functionality and macromolecular architecture.As shown in the previous chapters of this handbook, the RAFT process appears as one of the most interesting CRP techniques. First, RAFT polymerization is very similar to conventional radical polymerization since it only requires the addition of a chain-transfer agent (CTA) in the medium. Second, RAFT is a very versatile process able to control the (co)polymerization of a large variety of monomers leading to a virtually unlimited macromolecular design library.As a consequence, RAFT polymerization is a well-suited and promising technique to prepare high-performance polymers for a wide range of applications. Indeed, an efficient control at the macromolecular level is a very important step to control and improve the macroscopic properties of the final materials ( Fig. 13.1).

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“…These data were applied as the input parameters for the PS-b-PMMA copolymers in the present study. Immiscible graft and block copolymers made of PS and PMMS blocks have potential applications in keratoprosthesis modification [31], drug carriers [32], and biomedical materials [33][34]. However, there is a lack of publications regarding the inducing effects of substrates on the miktoarm PS-b-PMMA copolymer, which has motivated us to investigate this polymer system.…”

Section: Introductionmentioning

confidence: 99%

Changes in the phase morphology of miktoarm PS-b-PMMA copolymer induced by a monolayer surface

Wang

2015

Colloid Polym Sci

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It is known that polystyrene (PS) and poly(methyl methacrylate) (PMMA) blocks are immiscible at 383, 413, and 443 K and that their Flory-Huggins interaction parameters have the same blending ratio dependence at those temperatures. In this study, the phase morphologies of six groups of 12 miktoarm PS-b-PMMA copolymers were investigated at 383, 413, and 443 K via MesoDyn simulations. There is nearly no change for the same copolymer under different temperatures. We designed four series of patterned surfaces (18 total) and found that the inducing effect of these surfaces has some influence on the microscopic phase morphology of the polymers, including a reinforcing immiscible effect and a weakening immiscible effect. The degree of phase separation depended on the molecular architecture of the block copolymers, temperature, and the characteristics of the inducing surfaces. Higher temperature and higher PS-rich component copolymers exhibited higher order parameters. The co-4432 and co-8832 surfaces exhibited the most intensive inducing effect because of their 16 and 32 independent micro-environments, respectively. A set of comparative simulations was carried out with a high interaction energy between the polymeric species. The results confirmed the possibility of forming a hexagonal columnar phase with a core shell composed of the designed molecular structures as well as demonstrated the potential application of micro-environments in producing special mesoscopic structures.

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Control of cell adhesion on poly(methyl methacrylate)

Cited by 93 publications

References 14 publications

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

Toward New Materials Prepared via the RAFT Process: From Drug Delivery to Optoelectronics?

Changes in the phase morphology of miktoarm PS-b-PMMA copolymer induced by a monolayer surface

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Control of cell adhesion on poly(methyl methacrylate)

Cited by 93 publications

References 14 publications

αvβ3 Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

αvβ3 Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

Toward New Materials Prepared via the RAFT Process: From Drug Delivery to Optoelectronics?

Changes in the phase morphology of miktoarm PS-b-PMMA copolymer induced by a monolayer surface

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Product

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α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers