Surface modification of the Ti surface with nanoscale bio-MOF-1 for improving biocompatibility and osteointegration <i>in vitro</i> and <i>in vivo</i>

Wu, Jiaxin; Jiang, Shaokang; Xie, Wenjia; Xue, Yiyuan; Qiao, Mingxin; Yang, Xiangjun; Zhang, Xin; Wan, Qianbing; Wang, Jian; Chen, Junyu; Pei, Xibo

doi:10.1039/d2tb01311h

Cited by 15 publications

(15 citation statements)

References 91 publications

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“…Micro-CT reconstruction of the femoral condyle was observed at 8 weeks on Cu-TiO 2 coating (A); fuchsin-methylene blue staining of new bone formation at 8 weeks on Ti (B) and Cu-TiO 2 (C) coating; histological evaluation of control (D) and silver ion (E) implant groups; bone regeneration capability of the AHF (F) and MOF-1 coating (G) in rabbit models of tibia defect; H&E (H) staining and OCN (I) staining of rabbit tibia to evaluate osteogenesis around implants; micro-CT reconstructions of the new bone formation around implants in the AHT (L) and MOF-1 (M) groups; micro-CT reconstruction images uncoated (J) and Sr-Zn-F-Ti (K). ,, Panels A, B, and C are reproduced using permission from ref . Copyright 2021 Springer.…”

Section: Np Surface Modification With Metalsmentioning

confidence: 99%

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Surface Modification of Titanium Implants by Metal Ions and Nanoparticles for Biomedical Application

Gao

Wang

et al. 2023

ACS Biomater. Sci. Eng.

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Implant surface modification can improve osseointegration and reduce peri-implant inflammation. Implant surfaces are modified with metals because of their excellent mechanical properties and significant functions. Metal surface modification is divided into metal ions and nanoparticle surface modification. These two methods function by adding a finishing metal to the surface of the implant, and both play a role in promoting osteogenic, angiogenic, and antibacterial properties. Based on this, the nanostructural surface changes confer stronger antibacterial and cellular affinity to the implant surface. The current paper reviews the forms, mechanisms, and applications of nanoparticles and metal ion modifications to provide a foundation for the surface modification of implants.

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Section: Np Surface Modification With Metalsmentioning

confidence: 99%

Section: Np Surface Modification With Metalsmentioning

confidence: 99%

Surface Modification of Titanium Implants by Metal Ions and Nanoparticles for Biomedical Application

Gao

Wang

et al. 2023

ACS Biomater. Sci. Eng.

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“…Besides existing Zn-MOFs including ZIF-8, more novel Zn-MOFs like nano bio-MOF-1 provide another research direction for future. 184,185 Bioactive ceramics containing zinc Bioactive ceramics are one prominent category of biomaterials. Calcium phosphate ceramics (CPCs) are widely used in bone repair due to their similar constituents to bone tissue.…”

Section: Zn-based Mofsmentioning

confidence: 99%

“…Besides existing Zn-MOFs including ZIF-8, more novel Zn-MOFs like nano bio-MOF-1 provide another research direction for future. 184,185…”

Section: Application Of Zinc-based Biomaterials In Bone Repair and Re...mentioning

confidence: 99%

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Wen,

Wang,

Pei

et al. 2023

J. Mater. Chem. B

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“…Both their metal ions and organic ligands can be designed as catalytic sites . Owing to the chemical diversity, high porosity, and potential metal ion transport capacity of MOFs, they are widely used in various biomedical fields, such as bioimaging, antibacterial infection, , skin tissue regeneration, − and cancer treatment . MOFs can embed the enzyme in their tight cavities, significantly reducing the enzyme structural changes and maintaining enzyme activity.…”

Section: Introductionmentioning

confidence: 99%

Dual-Functional Nanoplatform Based on Bimetallic Metal–Organic Frameworks for Synergistic Starvation and Chemodynamic Therapy

Lai

Zheng³

et al. 2023

ACS Biomater. Sci. Eng.

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Tumor microenvironment (TME)-responsive chemodynamic therapy (CDT) mediated by nanozymes has been extensively studied in oral squamous cell carcinoma. However, the low catalytic efficiency due to insufficient H2O2 in the TME is still a major challenge for its clinical translation. Herein, we present an antitumor nanoplatform based on a Mn–Co organometallic framework material (MnCoMOF), which shows peroxidase-like (POD-like) activity, loaded with glucose oxidase (GOx@MnCoMOF), demonstrating the ability of H2O2 self-supply and H2O2 conversion to toxic hydroxyl radicals. The encapsulated GOx efficiently catalyzes glucose into gluconic acid and H2O2 at the tumor site, which can cut off the energy supply to inhibit tumor growth and produce a large amount of H2O2 and acid to compensate for their lack in the tumor microenvironment. The POD-like activity of MnCoMOF can convert H2O2 into hydroxyl radicals and eliminate tumor cells. The nanoplatform exhibits enhanced tumor cell cytotoxicity in a high-glucose medium compared with a low-glucose medium, illustrating sufficient generation of H2O2 from glucose by GOx. The in vivo results indicate that GOx@MnCoMOF has excellent antitumor efficacy and can remodel the immune-suppressive tumor microenvironment. In conclusion, the GOx@MnCoMOF nanoplatform possesses dual enzymatic activities, i.e., POD-like and glucose oxidase, to achieve improved tumor-suppressive efficiency through synergistic starvation and chemodynamic therapy, thus providing a new strategy for the clinical treatment of oral cancer.

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Surface modification of the Ti surface with nanoscale bio-MOF-1 for improving biocompatibility and osteointegration in vitro and in vivo

Abstract: Biocompatibility and osteointegration of implants are highly desired in orthopedic and dentistry applications. The synthesis of a coating with ideal biocompatibility and osteogenic effect carries practical significance for improving the...

Cited by 15 publications

References 91 publications

Surface Modification of Titanium Implants by Metal Ions and Nanoparticles for Biomedical Application

Surface Modification of Titanium Implants by Metal Ions and Nanoparticles for Biomedical Application

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Dual-Functional Nanoplatform Based on Bimetallic Metal–Organic Frameworks for Synergistic Starvation and Chemodynamic Therapy

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