Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Wen, Xinyu; Wang, Jian; Pei, Xibo; Zhang, Xin

doi:10.1039/d3tb01874a

Cited by 8 publications

(3 citation statements)

References 234 publications

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“… 45–47 In addition, Zn-GPC also has favorable biocompatibility. 48 , 49 These data suggest that Zn-GPCs may have the potential to bond directly to living bone tissue after implantation, further improving fracture healing and the stability of the vertebral body. 49 In spite of its positive attributes, Zn-GPC is a self-curing free-radical polymerization system and once the components of the experimental Zn-GPC composite are mixed, they have a working set time of 55 seconds.…”

Section: Zinc-based Polyalkenoate Cementmentioning

confidence: 89%

Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

Williams,

Adler,

Smokoff

et al. 2024

JPR

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Vertebral compression fractures (VCFs) are common in osteoporotic patients, with a frequency projected to increase alongside a growing geriatric population. VCFs often result in debilitating back pain and decreased mobility. Cement augmentation, a minimally invasive surgical technique, is widely used to stabilize fractures and restore vertebral height. Acrylic-based cements and calcium phosphate cements are currently the two primary fill materials utilized for these procedures. Despite their effectiveness, acrylic bone cements and calcium phosphate cements have been associated with various intraoperative and postoperative incidents impacting VCF treatment. Over the past decade, discoveries in the field of biomedical engineering and material science have shown advancements toward addressing these limitations. This narrative review aims to assess the potential pitfalls and barriers of the various types of bone cements.

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Section: Zinc-based Polyalkenoate Cementmentioning

confidence: 89%

Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

Williams,

Adler,

Smokoff

et al. 2024

JPR

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“…Zinc ion is also a relatively rich trace element in the human body, involved in various biological reactions, especially bone metabolism ( Raj Preeth et al, 2021 ; Wen et al, 2023 ). Some metalloenzymes in the body are regulated and catalyzed by zinc ions, such as ALP, which is closely related to the maturation of new bone.…”

Section: Discussionmentioning

confidence: 99%

Zinc-energized dynamic hydrogel accelerates bone regeneration via potentiating the coupling of angiogenesis and osteogenesis

Lv,

Zhou,

Hong

et al. 2024

Front. Bioeng. Biotechnol.

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Insufficient initial vascularization plays a pivotal role in the ineffectiveness of bone biomaterials for treating bone defects. Consequently, enhancing the angiogenic properties of bone repair biomaterials holds immense importance in augmenting the efficacy of bone regeneration. In this context, we have successfully engineered a composite hydrogel capable of promoting vascularization in the process of bone regeneration. To achieve this, the researchers first prepared an aminated bioactive glass containing zinc ions (AZnBg), and hyaluronic acid contains aldehyde groups (HA-CHO). The composite hydrogel was formed by combining AZnBg with gelatin methacryloyl (GelMA) and HA-CHO through Schiff base bonding. This composite hydrogel has good biocompatibility. In addition, the composite hydrogel exhibited significant osteoinductive activity, promoting the activity of ALP, the formation of calcium nodules, and the expression of osteogenic genes. Notably, the hydrogel also promoted umbilical vein endothelial cell migration as well as tube formation by releasing zinc ions. The results of in vivo study demonstrated that implantation of the composite hydrogel in the bone defect of the distal femur of rats could effectively stimulate bone generation and the development of new blood vessels, thus accelerating the bone healing process. In conclusion, the combining zinc-containing bioactive glass with hydrogels can effectively promote bone growth and angiogenesis, making it a viable option for the repair of critical-sized bone defects.

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“…Herein, the impact of extracellular Zn ions on cellular function and the molecular mechanism underlying the beneficial effects of Zn-based implants are summarized systematically and in detail. In general, Zn ions have multiple functions in bone repair and regeneration, including the promotion of osteogenic differentiation of mesenchymal stem cells (MSCs), the enhancement of osteoblastic bone formation, and the inhibition of osteoclastic bone resorption [ 46 , 47 ]. Also, Zn ions may stimulate angiogenesis and induce immunomodulation, leading to new bone formation [ 48 ].…”

Section: Underlying Mechanisms For the Improvement Of Bone Repair And...mentioning

confidence: 99%

Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms

Li,

Dai,

et al. 2024

Materials Today Bio

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Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Abstract: Zinc (Zn) is one of the most important trace elements in human body and plays a key role in various physiological processes, especially in bone metabolism. Zn-containing materials have been...

Cited by 8 publications

References 234 publications

Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

Zinc-energized dynamic hydrogel accelerates bone regeneration via potentiating the coupling of angiogenesis and osteogenesis

Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms

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