Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface

Čejková, Jitka; Trošan, Peter; Čejka, Čestmír; Lenčová, Anna; Zajı́cová, Alena; Javorková, Eliška; Kubinová, Šárka; Syková, Eva; Holáň, Vladimı́r

doi:10.1016/j.exer.2013.10.002

Cited by 91 publications

(86 citation statements)

References 34 publications

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“…Both mouse and rabbit BMSCs transplanted onto the ocular surface have been shown to suppress local inflammation. 104,105 Moreover, our recent work has demonstrated that UMSCs inhibit the polarization of M1 macrophages and lead to the maturation of M2 macrophages.…”

Section: Therapeutic Potential Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

et al. 2016

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Mesenchymal stem cells (MSCs) are a group of fibroblast-like multipotent mesenchymal stromal cells that have the ability to differentiate into osteoblasts, adipocytes, and chondrocytes. Recent studies have demonstrated that MSCs possess a unique ability to exert suppressive and regulatory effects on both adaptive and innate immunity in an autologous and allogeneic manner. A vital step in stem cell transplantation is overcoming the potential graft-versus-host disease, which is a limiting factor to transplantation success. Given that MSCs attain powerful differentiation capabilities and also present immunosuppressive properties, which enable them to survive host immune rejection, MSCs are of great interest. Due to their ability to differentiate into different cell types and to suppress and modulate the immune system, MSCs are being developed for treating a plethora of diseases, including immune disorders. Moreover, in recent years, MSCs have been genetically engineered to treat and sometimes even cure some diseases, and the use of MSCs for cell therapy presents new perspectives for overcoming tissue rejection. In this review, we discuss the potential extrinsic and intrinsic mechanisms that underlie MSCs’ unique ability to modulate inflammation, and both innate and adaptive immunity.

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Section: Therapeutic Potential Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

et al. 2016

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“…Nanofibers are used not only for remove extra body fluids from the wound area but also for wound healing. Cejkova et al (2013) examined that nanofiber scaffolds loaded with rabbit bone marrow derived MSCs effectively lowered apoptotic cell death, reduce alkali-induced oxidative stress in the rabbit cornea, decreased pro-inflammatory, and cytokine matrix metalloproteinase production (Cejkova et al 2013). Nanofibers also assistance in rinsing the exogenous micro-organism and accelerating the healing process (Garg and Goyal 2014).…”

Section: Transdermal Systems and Wound Dressingsmentioning

confidence: 99%

Drug loading and delivery using nanofibers scaffolds

Mohammadian

Eatemadi

2016

Artificial Cells, Nanomedicine, and Biotechnology

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In recent times, notable advancement has been made in the field of electrospinning for the fabrication of numerous types of nanofiber scaffolds. Due to the ultrathin fiber diameter, electrospun nanofiber scaffolds are considered to be an operational delivery system for biomolecules, genes, as well as drugs due to the high specific surface area and stereological porous structure. Here, we introduce some of methods for the integration of drugs and biomolecules within electrospun nanofiber scaffolds, such as blending, surface modification, coaxial process, and emulsion methods. Then, we describe some important biomedical applications of nanofibers in drug delivery systems along with their suitable examples in transdermal systems and wound dressings, cancer therapy, growth factor delivery, nucleic acid delivery, and stem cell delivery.

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“…Cornea is avascular and maintaining the avascularity is crucial for transparency. MSCs cultured on electrospun fibers controls the vascularization in vivo and improves the corneal healing [43] as shown in the Fig. 2.…”

Section: Ocular Tissue Engineeringmentioning

confidence: 99%

“…Cejkova et al [43] reported that alkali induced oxidative stress on the rabbit cornea was effectively treated using the stem cells cultured on ESM. Cornea is avascular and maintaining the avascularity is crucial for transparency.…”

Section: Ocular Tissue Engineeringmentioning

confidence: 99%

Electrospun fibers in regenerative tissue engineering and drug delivery

Nagarajan

Pochat-Bohatier

Balme

et al. 2017

Pure and Applied Chemistry

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Abstract:Electrospinning is a versatile technique to produce micron or nano sized fibers using synthetic or bio polymers. The unique structural characteristic of the electrospun mats (ESM) which mimics extracellular matrix (ECM) found influential in regenerative tissue engineering application. ESM with different morphologies or ESM functionalizing with specific growth factors creates a favorable microenvironment for the stem cell attachment, proliferation and differentiation. Fiber size, alignment and mechanical properties affect also the cell adhesion and gene expression. Hence, the effect of ESM physical properties on stem cell differentiation for neural, bone, cartilage, ocular and heart tissue regeneration will be reviewed and summarized. Electrospun fibers having high surface area to volume ratio present several advantages for drug/biomolecule delivery. Indeed, controlling the release of drugs/biomolecules is essential for sustained delivery application. Various possibilities to control the release of hydrophilic or hydrophobic drug from the ESM and different electrospinning methods such as emulsion electrospinning and coaxial electrospinning for drug/biomolecule loading are summarized in this review.

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Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface

Cited by 91 publications

References 34 publications

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System

Drug loading and delivery using nanofibers scaffolds

Electrospun fibers in regenerative tissue engineering and drug delivery

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