Electrospun fibers in regenerative tissue engineering and drug delivery

Abstract

Abstract:Electrospinning is a versatile technique to produce micron or nano sized fibers using synthetic or bio polymers. The unique structural characteristic of the electrospun mats (ESM) which mimics extracellular matrix (ECM) found influential in regenerative tissue engineering application. ESM with different morphologies or ESM functionalizing with specific growth factors creates a favorable microenvironment for the stem cell attachment, proliferation and differentiation. Fiber size, alignment and mechanical properties affect also the cell adhesion and gene expression. Hence, the effect of ESM physical properties on stem cell differentiation for neural, bone, cartilage, ocular and heart tissue regeneration will be reviewed and summarized. Electrospun fibers having high surface area to volume ratio present several advantages for drug/biomolecule delivery. Indeed, controlling the release of drugs/biomolecules is essential for sustained delivery application. Various possibilities to control the release of hydrophilic or hydrophobic drug from the ESM and different electrospinning methods such as emulsion electrospinning and coaxial electrospinning for drug/biomolecule loading are summarized in this review.

Nanofibers as new-generation materials: From spinning and nano-spinning fabrication techniques to emerging applications

“…Therefore, here, we will briefly summarize the history and development of nanofiber fabrication techniques (spinning and non-spinning approaches). We will then describe the main categories of nanofiber fabrication techniques and the emerging applications in different fields, such as environmental remediation, healthcare, and biomedical engineering [15][16][17], energy production and storage [18][19][20], water treatment [21][22][23][24][25][26][27][28], air filtration, sensors [29][30][31][32] and electronics. In each section, we will mention selected studies to explain how nanofibers can be exploited to refine the operational performance of various inorganic, organic, carbon and composite membranes.…”

Electrospun Nanofibers for Label-Free Sensor Applications

“…Electrospinning can also be helpful in fabrication of biodegradable and biocompatible membranes for tissue engineering. Different biocompatible polymers such as polylactic acid, or poly lactic-co-glycolic acid materials have been used to make bio-friendly and highly porous membranes through electrospinning [58]. In addition, a high strain gelatin-based membrane has also been developed for bone tissue engineering, where this biocompatible membrane can provide the high mechanical properties and stability needed for orthopedic applications [59].…”

Preparation of Lutein-Loaded PVA/Sodium Alginate Nanofibers and Investigation of Its Release Behavior

“…Electrospinning has attracted more and more attention from the past decade due to its potential use in biomedical materials, filtration, catalysis, optoelectronics, food engineering, cosmetics, and drug delivery devices [5,6,7]. Among which drug delivery is one of the most promising applications.…”