Drug loading and delivery using nanofibers scaffolds

Mohammadian, Farideh; Eatemadi, Ali

doi:10.1080/21691401.2016.1185726

Cited by 71 publications

(31 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, with current research works ARNIs may well soon more efficient angiotensin receptor blockers (ARBs), ushering a new dawn of compound system modulation that will shed more light on the treatment of cardiovascular disease. Finally, extensive studies should be done on the NPs and LCZ696 to further elucidate and clarify its mechanisms of its potential cardio-renal and cardiovascular protection (44)(45)(46)(47)(48)(49).…”

Section: Resultsmentioning

confidence: 99%

Untitled

2016

Cell Mol Biol

View full text Add to dashboard Cite

Brain natriuretic peptide (BNP), also known as a B-type natriuretic peptide, is one of the important biomarkers with a proven role in the diagnosis of congestive heart failure (CHF). Researchers from the different clinical field have researched into the performance features of BNP testing in the acute care setup to assist and improve in diagnosing CHF and in predicting future morbidity and mortality rates. The potency of BNP has also been researched into in cases like myocardial ischemia and infarction, cor pulmonale, and acute pulmonary embolism (PE). Based on their vaso-dilatory and diuretic properties and ability to inhibit renin-angiotensin-aldosterone system, natriuretic peptides are able to provide an efficient technique and mechanism of action in the pathophysiologic framework for CHF treatment and management. Recent clinical studies reported that ularitide, a synthetic form of urodilatin, secreted by kidney may be effective in managing and treatment of decompensated heart failure. It has also been reported that Nesiritide, a recombinant natriuretic peptide has been proven to improve dyspnea and hemodynamic parameters in heart failure patients. This review provides an update on natriuretic peptides and their therapeutic potential in CHF treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Untitled

2016

Cell Mol Biol

View full text Add to dashboard Cite

show abstract

“…Conducive to cell respiration and gas penetration [26] Cross-linked porosity Can meet the need of cutting [27,28] Mechanical strength Similar to human skin tissue [40] 2 Journal of Nanomaterials epithelial regeneration of tissue [48]. Therefore, CS-based nanocomposites are widely used in wound healing, tissue engineering, and drug delivery [49].…”

Section: Ideal Characteristic Advantage Referencesmentioning

confidence: 99%

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Fa-dong

Jia

et al. 2020

Journal of Nanomaterials

View full text Add to dashboard Cite

Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers. Various polymers have been successfully electrospun into ultrafine fibers in recent years. These electrospun biopolymer nanofibers have potential applications for wound dressing based upon their unique properties. In this paper, a comprehensive review is presented on the researches and developments related to electrospun biopolymer nanofibers including processing, structure and property, characterization, and applications. Information of those polymers together with their processing condition for electrospinning of ultrafine fibers has been summarized in the paper. The application of electrospun natural biopolymer fibers in wound dressings was specifically discussed. Other issues regarding the technology limitations, research challenges, and future trends are also discussed.

show abstract

“…A drug aqueous solution is mixed with a hydrophobic polymer solution, defined as the oily phase. After electrospinning, the drug-loaded aqueous phase is dispersed within the nanofiber matrix; core-shell nanofibers can be obtained when the polymer is also dispersed in the aqueous phase [ 148 ]. The main advantage of such a technique is to avoid drug stability problems possibly due to polymer and drug dissolution in respective suitable solvents.…”

Section: Overview Of Promising Nanotechnology Approaches For the Tmentioning

confidence: 99%

“…In comparison with the coaxial electrospinning, the emulsion technique could determine degradation of unstable macromolecules, due to the interfacial tensions at the organic/aqueous interface of the emulsion. Several problems may be encountered, for example, with proteins due to their size and three-dimensional structure [ 146 , 148 , 149 , 150 ].…”

Section: Overview Of Promising Nanotechnology Approaches For the Tmentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury

et al. 2017

View full text Add to dashboard Cite

The complex pathophysiology of spinal cord injury (SCI) may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. A primary mechanical injury in the spinal cord triggers a cascade of secondary events, which are involved in SCI instauration and progression. The aim of the present review is to provide an overview of the therapeutic neuro-protective and neuro-regenerative approaches, which involve the use of nanofibers as local drug delivery systems. Drugs released by nanofibers aim at preventing the cascade of secondary damage (neuro-protection), whereas nanofibrous structures are intended to re-establish neuronal connectivity through axonal sprouting (neuro-regeneration) promotion, in order to achieve a rapid functional recovery of spinal cord.

show abstract

Drug loading and delivery using nanofibers scaffolds

Cited by 71 publications

References 82 publications

Untitled

Untitled

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury

Contact Info

Product

Resources

About