Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Wu, Hao; Hu, Yangnan; Wang, Junguo; Gao, Xia; Qian, Xiaoyun; Tang, Mingliang

doi:10.2147/ijn.s321984

Cited by 73 publications

(54 citation statements)

References 114 publications

(140 reference statements)

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“…In addition, the specific features of the various formulations also have to be carefully considered, as the size and surface functionalization of SPIONs can strikingly affect the toxicity. Therefore, studies focusing on the biological distribution and metabolic pathways of the MNPs in cells or bodies will lead the future evolution of research in this field [61].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

“…Iron oxide-based MCs include: SPIOs (superparamagnetic iron oxide nanoparticles); USPIOs (ultrasmall superparamagnetic iron oxide nanoparticles); and MPIOs (microparticles of iron oxide). Although MCs are typically used to accelerate the transverse relaxation, some IONPs can also serve as T 1 contrast agents, primarily reducing the longitudinal relaxation time [61,[342][343][344]. The most commonly used MCs in the clinics are the USPIOs, which have typical diameters ranging from 20 to 50 nm and are characterized by a long circulation half-life.…”

Section: Imaging Techniques To Visualize Mcsmentioning

confidence: 99%

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Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

et al. 2022

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Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.

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Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Section: Imaging Techniques To Visualize Mcsmentioning

confidence: 99%

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

et al. 2022

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“…The low toxicity of SPIONs to healthy/normal cells offers a critical advantage, compared to other inorganic nanoparticles. SPIONs are also able to cross the nuclear membrane [ 127 ] and generate ROS [ 128 , 129 ]. In a study by Afrasiabi et al [ 130 ], SPIONs were shown to generate more ROS in oral squamous cell carcinoma (OSCC) mitochondria than in normal cell mitochondria.…”

Section: Mitochondria-targeting Nanoparticles For Advancing Cancer Th...mentioning

confidence: 99%

Recent Advancements in Mitochondria-Targeted Nanoparticle Drug Delivery for Cancer Therapy

Shamul

Kwizera

et al. 2022

Nanomaterials

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Mitochondria are critical subcellular organelles that produce most of the adenosine triphosphate (ATP) as the energy source for most eukaryotic cells. Moreover, recent findings show that mitochondria are not only the “powerhouse” inside cells, but also excellent targets for inducing cell death via apoptosis that is mitochondria-centered. For several decades, cancer nanotherapeutics have been designed to specifically target mitochondria with several targeting moieties, and cause mitochondrial dysfunction via photodynamic, photothermal, or/and chemo therapies. These strategies have been shown to augment the killing of cancer cells in a tumor while reducing damage to its surrounding healthy tissues. Furthermore, mitochondria-targeting nanotechnologies have been demonstrated to be highly efficacious compared to non-mitochondria-targeting platforms both in vitro and in vivo for cancer therapies. Moreover, mitochondria-targeting nanotechnologies have been intelligently designed and tailored to the hypoxic and slightly acidic tumor microenvironment for improved cancer therapies. Collectively, mitochondria-targeting may be a promising strategy for the engineering of nanoparticles for drug delivery to combat cancer.

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“…The clinical use of HIFU is increasing, but damage to the skin and adjacent healthy tissues cannot be ignored. Superparamagnetic iron oxide nanoparticles (SPIONs) have great prospects in the biomedical field, especially as ultrasound absorbers, owing to their reliable sources and excellent superparamagnetic properties ( Wei et al, 2021 ). Devarakonda et al (as cited in Sun et al, 2014 ) improved the thermal ablation effect of tumors by combining the advantages of SPIONs and polymers to construct PLGA-coated Fe 3 O 4 microcapsules to enable energy deposition and enhance the absorption of ultrasonic waves.…”

Section: Non-invasive Thermal Ablation Assisted By Transition-metal B...mentioning

confidence: 99%

Recent Advances in Transition-Metal Based Nanomaterials for Noninvasive Oncology Thermal Ablation and Imaging Diagnosis

et al. 2022

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With the developments of nanobiotechnology and nanomedicine, non-invasive thermal ablation with fewer side effects than traditional tumor treatment methods has received extensive attention in tumor treatment. Non-invasive thermal ablation has the advantages of non-invasiveness and fewer side effects compared with traditional treatment methods. However, the clinical efficiency and biological safety are low, which limits their clinical application. Transition-metal based nanomaterials as contrast agents have aroused increasing interest due to its unique optical properties, low toxicity, and high potentials in tumor diagnosis. Transition-metal based nanomaterials have high conversion efficiency of converting light energy into heat energy, good near-infrared absorption characteristics, which also can targetedly deliver those loaded drugs to tumor tissue, thereby improving the therapeutic effect and reducing the damage to the surrounding normal tissues and organs. This article mainly reviews the synthesis of transition-metal based nanomaterials in recent years, and discussed their applications in tumor thermal ablation and diagnosis, hopefully guiding the development of new transition metal-based nanomaterials in enhancing thermal ablation.

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Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Cited by 73 publications

References 114 publications

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

Recent Advancements in Mitochondria-Targeted Nanoparticle Drug Delivery for Cancer Therapy

Recent Advances in Transition-Metal Based Nanomaterials for Noninvasive Oncology Thermal Ablation and Imaging Diagnosis

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