Recent Advances in Transition-Metal Based Nanomaterials for Noninvasive Oncology Thermal Ablation and Imaging Diagnosis

Abstract

With the developments of nanobiotechnology and nanomedicine, non-invasive thermal ablation with fewer side effects than traditional tumor treatment methods has received extensive attention in tumor treatment. Non-invasive thermal ablation has the advantages of non-invasiveness and fewer side effects compared with traditional treatment methods. However, the clinical efficiency and biological safety are low, which limits their clinical application. Transition-metal based nanomaterials as contrast agents have aroused increasing interest due to its unique optical properties, low toxicity, and high potentials in tumor diagnosis. Transition-metal based nanomaterials have high conversion efficiency of converting light energy into heat energy, good near-infrared absorption characteristics, which also can targetedly deliver those loaded drugs to tumor tissue, thereby improving the therapeutic effect and reducing the damage to the surrounding normal tissues and organs. This article mainly reviews the synthesis of transition-metal based nanomaterials in recent years, and discussed their applications in tumor thermal ablation and diagnosis, hopefully guiding the development of new transition metal-based nanomaterials in enhancing thermal ablation.

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

“…134 In recent years, transition metal dichalcogenide nanosheets have been reported for drug delivery and tissue ablation. 135 In 2013, Chou et al 136 prepared MoS 2 by a chemical exfoliation method and obtained a two-dimensional amphiphilic compound with good colloidal stability in aqueous media. Wang et al 137 explored the effect of MoS 2 on the brillation process of Ab fragments and human islet amyloid polypeptide (hIAPP) fragments.…”

“… 134 In recent years, transition metal dichalcogenide nanosheets have been reported for drug delivery and tissue ablation. 135 …”

Chiral Carbon Dots and Chiral Carbon Dots with Circularly Polarized Luminescence: Synthesis, Mechanistic Investigation and Applications

“…The development of nanomaterials for therapeutic diagnostics is an urgent task, and ideal candidates should simultaneously serve as markers for early diagnosis of diseases and have therapeutic effects. And their structural parameters and physicochemical properties should be efficiently tuned [101–114] . CCDs have a very high potential for biomedical applications due to their low toxicity and good biocompatibility.…”

Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Functionalized to EGF and Ce6 Complexes for Breast Cancer Diagnoses and Therapy

“…NIR is one of the light sources frequently used to activate the therapeutic effect in oncological phototherapy, due to its depth of tissue penetration and its non-harmful absorption by water molecules and hemoglobin in biological tissues [ 16 ]. PTT involves the conversion of incident light into heat with the aid of photothermal transducer agents to facilitate thermal ablation in tumor tissues [ 15 , 16 , 17 , 18 ]. Significant advantages of PTT over conventional treatments include reduced invasiveness, high cancer cell specificity, and fast recovery [ 15 , 18 , 19 ].…”

“…PTT involves the conversion of incident light into heat with the aid of photothermal transducer agents to facilitate thermal ablation in tumor tissues [ 15 , 16 , 17 , 18 ]. Significant advantages of PTT over conventional treatments include reduced invasiveness, high cancer cell specificity, and fast recovery [ 15 , 18 , 19 ].…”