Superoxide Dismutase: Therapeutic Targets in SOD Related Pathology

Filip, Cristina; Albu, Elena; Zamosteanu, Nina

doi:10.4236/health.2014.610123

Cited by 15 publications

(6 citation statements)

References 56 publications

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“…Oxidative stress generated during rotenone intoxication as observed in this study could arise from metabolic consequence of mitochondrial dysfunction and incomplete glucose oxidation. More hydrogen peroxide is also produced when purines are been broke down to uric acid in the cell by XO (Cristiana et al, 2014). The free radical produced leads to oxidative damage that caused protein carbonylation and consequently attacks membrane lipid.…”

Section: Discussionmentioning

confidence: 99%

Taxifolin Alleviates Metabolic and Neurochemical Alterations in Hippocampus and Cortex of Brain of Rotenone-Toxified Rats in Vivo and Effectively Interacts with Enzymes Involve in Neurotransmission in Silico

Josiah¹,

Saliu²,

Umar³

et al. 2021

Preprint

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Rotenone is a naturally occurring compound and inhibitor of mitochondrial complex I. Its exposure is toxic and directly affects the function of mitochondrial which leads to neurodegeneration. Taxifolin is a flavonoid that exhibits therapeutic potentials in various neurodegenerative diseases via its anti-oxidative, anti-inflammatory and neuromodulatory properties. In this study, we evaluated the therapeutic potential of taxifolin to alleviate metabolic and neurochemical alterations in the hippocampal and cortical region of brain of rotenone-toxified rats in vivo and to assess its influence on some enzymes involve in neurotransmission in silico. Taxifolin (0.25, 0.5 and 1.0 mg/kg) was orally post-administered to male Wistar rats for 3 days after 10 days subcutaneous administration of rotenone. Activities of mitochondrial complex I, membrane ion pump and lactate dehydrogenase (LDH) were evaluated in the hippocampus and cortex of the brain of rotenone-toxified rats. Markers of neurotransmitter metabolism and oxidative stress were also biochemically estimated and molecular interaction between taxifolin and tyrosine hydroxylase, monoamine oxidase, glutamine synthetase and Na+K+ ATPase was determined by in silico simulation. Taxifolin attenuated dysfunction of mitochondrial, Na+K+ ATPase, LDH and modulate neurotransmitter metabolism. Also, the elicited oxidative stress was mitigated by taxifolin in the hippocampus and cortex of the brain of rotenone-toxified rats. The highest binding affinity was recorded in taxifolin and tyrosine hydroxylase complex. Hydrogen bond and hydrophobic interactions were the two key molecular interaction between the taxifolin and targeted enzymes. Thus, taxifolin significantly exert therapeutic effect against rotenone-induced neurotoxicity in rats via anti-oxidative, as well as mitochondrial and neurotransmitter modulatory activity.

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Section: Discussionmentioning

confidence: 99%

Taxifolin Alleviates Metabolic and Neurochemical Alterations in Hippocampus and Cortex of Brain of Rotenone-Toxified Rats in Vivo and Effectively Interacts with Enzymes Involve in Neurotransmission in Silico

Josiah¹,

Saliu²,

Umar³

et al. 2021

Preprint

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“…Increasing the activity of antioxidant enzymes like SOD can decrease levels of lipid peroxides acting as free radicals. SOD can also convert the free radical anion superoxide (2O 2 (11,32,34,35). Meanwhile, Mohebbi et al (36) reported that increased SOD activity was followed by an increase in glutathione peroxidase (GSPHx) enzyme activity.…”

Section: Discussionmentioning

confidence: 99%

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Arifah

Atho'illah

Lukiati

et al. 2020

MJMS

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Introduction: High fat diet (HFD) can cause lipid accumulation and contribute to various metabolic disorders. Single clove garlic oil (SCGO) has advantages over regular garlic due to its higher amounts of organosulfide compounds in particular. This study aimed to determine the ability of SCGO extract to ameliorate hepatic steatosis and improve oxidative status by modulating expression of tumour necrosis factor α and superoxide dismutase in mice fed a HFD.Methods: Twenty-four adult male Balb/C mice were divided into six groups: i) normal diet; ii) positive control diet; iii) negative control diet; and iv) HFD with SCGO at 12.5 mg/kg body weight (mg/kg BW); v) HFD with SCGO at 25 mg/kg BW, vi) HFD with SCGO at 50 mg/kg BW. Liver weight and morphology, spleen weight, serum levels of superoxide dismutase (SOD) and tumour necrosis factor α (TNF-α), TNF-α expression in the aorta and lipid profiles were assessed at the end of the experimental period.Results: SCGO treatment was associated with significant decreases in liver and spleen weight as well as amelioration of hepatic steatosis. SCGO treatment also decreased TNF-α levels and expression. Serum levels of SOD in the SCGO groups were significantly increased compared with the negative control group. Lipid profiles were improved in the SCGO treatment groups compared with the negative control group.Conclusion: SCGO as an herbal medicine could be an effective treatment for degenerative disorders caused by HFD.

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“…The superoxide radical has an unpaired electron within its orbital; the unpaired electron creates a reactive compound capable of producing oxidative damage [2,3]. …”

Section: Figurementioning

confidence: 99%

“…A free radical, for the purpose of this review, is defined as a compound that has one or more unpaired electrons in its orbital and is capable of finite existence (Figure 1) and includes superoxide [2,3]. Free radicals have extremely high chemical reactivity, which can in turn cause damage to cells.…”

Section: Introductionmentioning

confidence: 99%

Use of Saliva Biomarkers to Monitor Efficacy of Vitamin C in Exercise-Induced Oxidative Stress

Evans

Omaye

2017

Antioxidants

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Saliva is easily obtainable for medical research and requires little effort or training for collection. Because saliva contains a variety of biological compounds, including vitamin C, malondialdehyde, amylase, and proteomes, it has been successfully used as a biospecimen for the reflection of health status. A popular topic of discussion in medical research is the potential association between oxidative stress and negative outcomes. Systemic biomarkers that represent oxidative stress can be found in saliva. It is unclear, however, if saliva is an accurate biospecimen as is blood and/or plasma. Exercise can induce oxidative stress, resulting in a trend of antioxidant supplementation to combat its assumed detriments. Vitamin C is a popular antioxidant supplement in the realm of sports and exercise. One potential avenue for evaluating exercise induced oxidative stress is through assessment of biomarkers like vitamin C and malondialdehyde in saliva. At present, limited research has been done in this area. The current state of research involving exercise-induced oxidative stress, salivary biomarkers, and vitamin C supplementation is reviewed in this article.

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Superoxide Dismutase: Therapeutic Targets in SOD Related Pathology

Cited by 15 publications

References 56 publications

Taxifolin Alleviates Metabolic and Neurochemical Alterations in Hippocampus and Cortex of Brain of Rotenone-Toxified Rats in Vivo and Effectively Interacts with Enzymes Involve in Neurotransmission in Silico

Taxifolin Alleviates Metabolic and Neurochemical Alterations in Hippocampus and Cortex of Brain of Rotenone-Toxified Rats in Vivo and Effectively Interacts with Enzymes Involve in Neurotransmission in Silico

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Use of Saliva Biomarkers to Monitor Efficacy of Vitamin C in Exercise-Induced Oxidative Stress

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