Superiority of calcium-containing nanowires modified titanium surface compared with SLA titanium surface in biological behavior of osteoblasts: A pilot study

Ming, Pan-pan; Shao, Shui-yi; Qiu, Jing; Yang, Jie; Yu, Yongqi; Chen, Jiaxi; Zhu, Wenqing; Tang, Chunbo

doi:10.1016/j.apsusc.2017.04.152

Cited by 25 publications

(8 citation statements)

References 48 publications

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“…The composition of nanostructured titanate layers on Ti surfaces is H 2 Ti 2 O 5 ∙H 2 O and Na 2 Ti 2 O 5 ∙H 2 O after hydrothermal method [22]. By changing the concentration of NaOH to 10 mM according to previous studies [23], the surfaces of Ti-NW and Ti-NW-Zn samples in our study were covered with nanowire-like structures. However, no visible changes could be found on neither the Ti-NW nor the Ti-NW-Zn surfaces.…”

Section: Resultsmentioning

confidence: 99%

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Zhu

Shao

et al. 2019

J Nanobiotechnol

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Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. In this study, we explored the corrosion behaviors of four common materials (commercially pure Ti, cp-Ti; Sandblasting and acid etching-modified Ti, Ti-SLA; nanowires-modified Ti, Ti-NW; and zinc-containing nanowires-modified Ti, Ti-NW-Zn) with excellent biocompatibilities and osteogenic capacities under the macrophages induced-oxidizing microenvironment. The results showed that the materials immersed into a high oxidizing environment were more vulnerable to corrode. Meanwhile, different surfaces also showed various corrosion susceptibilities under oxidizing condition. Samples embed with zinc element exhibited more excellent corrosion resistance compared with other three surfaces exposure to excessive H 2 O 2 . Besides, we found that zinc-decorated Ti surfaces inhibited the adhesion and proliferation of macrophages on its surface and induced the M2 states of macrophages to better healing and tissue reconstruction. Most importantly, zinc-decorated Ti surfaces markedly increased the expressions of antioxidant enzyme relative genes in macrophages. It improved the oxidation microenvironment around the materials and further protected their properties. In summary, our results demonstrated that Ti-NW-Zn surfaces not only provided excellent corrosion resistance properties, but also inhibited the adhesion of macrophages. These aspects were necessary for maintaining osseointegration capacity and enhancing the corrosion resistance of Ti in numerous medical applications, particularly in dentistry.

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Section: Resultsmentioning

confidence: 99%

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Zhu

Shao

et al. 2019

J Nanobiotechnol

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“…Surface treatments for increasing surface roughness, as well as the incorporation of trace elements to make the titanium surface bioactive are responsible for empowering the wettability, bone anchoring, and biomechanical stability between the implant-bone interfaces, thus increasing osteoinduction and osteointegration (Jemat et al, 2015;Contaldo et al, 2021). Various methods have been used to incorporate trace elements into micro/nanostructure modified titanium surfaces (Ming et al, 2017;Shao et al, 2017). Traditional methods of nanostructure preparation included alkali-heat-treatment and acid-alkali-treatment (Pattanayak et al, 2009;Hu and Yang, 2014).…”

Section: Discussionmentioning

confidence: 99%

Hydrothermal Synthesis of Zinc-Incorporated Nano-Cluster Structure on Titanium Surface to Promote Osteogenic Differentiation of Osteoblasts and hMSCs

Tang

Liu

et al. 2021

Front. Mater.

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In this study, a novel modification strategy was established to synthesize a zinc-incorporated nano-cluster structure on titanium surface in a two-step hydrothermal reaction, and the osteogenic differentiation of osteoblasts and human bone marrow mesenchymal cells (hMSCs) was studied in the presence of this synthesized nanostructure. Analyses of the surface topography and elemental composition revealed that the zinc-containing cluster-like nanostructure was successfully prepared on the titanium surface. By altering the reaction time, three surface modifications were established. The three modified titanium surfaces had improved hydrophilicity and could continuously release zinc ions in a controlled manner. In vitro study displayed that three modified titanium surfaces, especially the samples prepared by reacting for 15 min, exhibited enhanced cell adhesion, proliferation, and osteogenic differentiation compared to the pure titanium surface. The study therefore conclude that the zinc-incorporated nano-cluster modification of titanium surface through a simple procedure can establish an enhanced osteogenic microenvironment and exhibit a potential strategy of titanium surface modification to accelerate the dental implant osseointegration.

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“…The chemical states of the components were also detected. The spectra were calibrated with respect to the C 1s signal at 284.8 eV [39]. The roughness and three-dimensional views of the surfaces of Ti-control, Ti-CSE-2, Ti-CSE-5, and Ti-CSE-10 samples were evaluated by confocal three-dimensional surface topography instrument (UP series, RTEC, USA).…”

Section: Methodsmentioning

confidence: 99%

Cigarette Smoke Extract Exposure: Effects on the Interactions between Titanium Surface and Osteoblasts

Yang

Shao

Chen

et al. 2019

BioMed Research International

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The aim of this study was to explore the changes in the characteristics of titanium surface and the osteoblast-titanium interactions under cigarette smoke extract (CSE) exposure. In this study, CSE was used to simulate the oral liquid environment around the implant under cigarette smoke exposure. Titanium samples were immersed in CSE to explore the changes in the characteristics of titanium surface. The physical properties of titanium surface were measured, including surface micromorphology, surface elemental composition, roughness, and surface hydrophilicity. MC3T3-E1 cells were cultured on the titanium surface in vitro under different concentrations of CSE exposure, and cell adhesion, cell proliferation, and osteogenic differentiation were observed. The surface micromorphology and elemental composition of titanium surface changed under CSE exposure. No obvious changes were found in the surface roughness and the hydrophilicity of titanium samples. Moreover, the results of in vitro study showed that CSE exposure downregulated the cell spreading, proliferation, and osteogenic differentiation of MC3T3-E1 cells on the titanium surface. It could be speculated that some carbon-containing compounds from CSE adsorbed on the titanium surface and the osteoblast-titanium interactions were influenced under CSE exposure. It is hoped that these results could provide valuable information for further studies on smoking-mediated inhibition of implants osseointegration.

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Superiority of calcium-containing nanowires modified titanium surface compared with SLA titanium surface in biological behavior of osteoblasts: A pilot study

Cited by 25 publications

References 48 publications

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Hydrothermal Synthesis of Zinc-Incorporated Nano-Cluster Structure on Titanium Surface to Promote Osteogenic Differentiation of Osteoblasts and hMSCs

Cigarette Smoke Extract Exposure: Effects on the Interactions between Titanium Surface and Osteoblasts

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