Supercritical fluid extraction employing a variable restrictor coupled to gas chromatography via a sample pre‐concentration trap

Strode, J.T.B.; Taylor, Larry T.

doi:10.1002/jhrc.1240191112

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Burford et al reviewed the instrumentation and applications of online SFE/GC [65]. Two studies looked at the use of cryogenic analyte preconcentration future science group traps prior to SFE-GC [63,66]. Meanwhile, Lou et al compared the chromatographic performance of split/splitless and programmed temperature, vaporizer injection methods in directly coupled SFE-GC [67].…”

Section: Sfe-coupled Techniquesmentioning

confidence: 99%

Bioanalytical Applications Using Supercritical Fluid Techniques

2009

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The bioanalytical applications of supercritical fluid techniques, such as supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC), are of increasing interest. The main role of these techniques is in the sample preparation and separation of biologically active compounds, particularly drugs and their metabolites, as well as endogenous compounds. An insight is given into the different types of extracting fluids and modifiers, detectors, stationary phases, mobile phases and collection strategies. A critical discussion is presented on the existing state of the art concerning the applications of SFC and SFE with a specific focus on its advantages and limitations in the bioanalytical field. New developments and the possibilities for routine work in the near future are also covered.

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Section: Sfe-coupled Techniquesmentioning

confidence: 99%

Bioanalytical Applications Using Supercritical Fluid Techniques

2009

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“…Burford et al reviewed the instrumentation and applications of on-line SFE/GC (258). Two studies looked at the use of cryogenic analyte preconcentration traps prior to SFE/GC (259,260). Meanwhile, Lou et al compared the chromatographic performance of split/splitless and programmedtemperature, vaporizer injection methods in directly coupled SFE/ GC (261).…”

Section: Supercritical Fluid Extractionmentioning

confidence: 99%

Supercritical Fluid Chromatography and Extraction

1998

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“…Analysts have generally taken one of three approaches. Some researchers have made use of external traps as an interface between the two systems. − These traps often have larger active cross sections than open tubular columns which result in lower linear velocities. If packed with sorbent, a lower phase ratio is possible.…”

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confidence: 99%

SFE-GC with Quantitative Transfer of the Extraction Effluent to a Megabore Capillary Column

Stone

Taylor

2000

Anal. Chem.

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Supercritical fluid extraction was directly coupled with gas chromatography such that the entire extraction effluent was directed onto the GC column. A sealed connection between the restrictor and the column ensured that no loss of analyte could occur. The elevated pressure generated in the column itself resulted in a reduced flow rate through the column, making efficient trapping possible. Metal-jacketed capillary columns were used as they can tolerate the elevated pressures required. In addition to maximizing sensitivity, very practical extraction parameters were possible. For a 25-min extraction, with a 2.2 mL/min flow rate, and the column at 40 degrees C, analytes as volatile as C-14 were trapped and separated. Trapping efficiency improved further with shorter extraction times, mild cooling of the column, or lower flow rates.

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Supercritical fluid extraction employing a variable restrictor coupled to gas chromatography via a sample pre‐concentration trap

Cited by 4 publications

References 16 publications

Bioanalytical Applications Using Supercritical Fluid Techniques

Bioanalytical Applications Using Supercritical Fluid Techniques

Supercritical Fluid Chromatography and Extraction

SFE-GC with Quantitative Transfer of the Extraction Effluent to a Megabore Capillary Column

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