¹³C-nmr Assignments for Lactone-Type Norditerpenoid Alkaloids

Conversional Synthesis of Heteratisine

“…Finally, hydrolysis of 13 with ammonium hydroxide afforded the target compoud heteratisine (1) (Scheme 2). The NMR spectra for 13 and 1 were identical with those of the natural alkaloids respectively, as reported in the literature [8].…”

Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

“…Compound unsaturation and an IR absorption (1637 cm −1 ). Thus, the structure of 3 was established, and named as tangutidine C. The known alkaloids (4-7) were identified to be tanaconitine [10], heteratisine [14], trolline [17] and isocorydine [18], by comparison with published physical and spectroscopic data. Alkaloids 6 and 7 were first reported from A. tanguticum.…”

“…The known alkaloids ( 4 – 7 ) were identified to be tanaconitine [ 10 ], heteratisine [ 14 ], trolline [ 17 ] and isocorydine [ 18 ], by comparison with published physical and spectroscopic data. Alkaloids 6 and 7 were first reported from A. tanguticum .…”

“…Previous phytochemical investigation of A. tanguticum showed that it contained diterpene alkaloids, flavonoids, phenolic acids, glycosides, etc. [6][7][8][9][10][11][12][13][14][15][16]. However, most of the studies on diterpene alkaloids in A. tanguticum focused on its fat-soluble part and few focused on the water-soluble part.…”

Bis-Diterpenoid Alkaloids from Aconitum Tanguticum Var. Trichocarpum

“…trichocarpum was investigated. The investigation led to the isolation of two new heteratisine-hetidinetype bisditerpenoid alkaloids designated as trichocarpines A 1 and B 2, as well as twelve known alkaloids, 6-acetylheteratisine, 6-benzoylheteratisine, dehydrheteratisine, dihydrogeyerine, geyerinine, guan-fu base Z, heteratisine, heterophyllidine, heterophylline, tangirine 3, tongolinine, and venulol [3][4][5][6][7][8][9][10]. Trichocarpines A 1 and B 2 consist of a lactone-type C 19 -diterpenoid alkaloid moiety and a hetidine-type C 20 -diterpenoid alkaloid moiety.…”