Bis-Diterpenoid Alkaloids from Aconitum Tanguticum Var. Trichocarpum

Abstract

Two new, rare heteratisine-hetidine-type bisditerpenoid alkaloids designated as trichocarpines A 1 and B 2, together with twelve known compounds have been isolated from the whole plants of Aconitum tanguticum var. trichocarpum. Their structures were elucidated by spectroscopic data interpretation and chemical transformation.

Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices

“…109 For the heterodimers, heteratisine–hetidine-type dimeric alkaloids 177–179 and atisine–denudatine-type dimeric alkaloids 180–182 were isolated from the genus Aconitum . 108,110–112 Biological activity tests indicated that 167 exhibited significant neuroprotective activity at 10 nM, and 176 exhibited cytotoxic activities against HL-60, SMMC-7721, A549, MCF-7, and SW480 with IC 50 values of 13.50, 18.52, 17.22, 11.18, and 16.36 μM, respectively.…”

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

“…Almost all of the C 20 -diterpenoid alkaloids contain oxygenated groups. However, in contrast to the C 19 -diterpenoid alkaloids, C 20 -DAs possess the following distinctive features [ 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 ]: Most of them do not contain a methoxy group in their structures as C 19 -DAs [ 108 ]; Some alkaloids contain an acetoxy group or benzoyloxy ester group, or both, and do not incl...…”

“…Hetidine–hetisine comprises a hetidine-type and a hetisine-type C 20 -DA with an oxygen atom linking hetidine and hetisine in the compound. Heteratisine–hetidine links a lactone-type C 19 -DA and a hetidine-type C 20 -DA [ 154 , 155 , 156 , 157 , 158 ].…”