Three new diterpene alkaloids, tangutidines A–C (1–3), and four known alkaloids (4–7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1–3) were obtained for the first time. The structures of 1–3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.
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are synthesized and are examined for their antiproliferative effects on a panel of carcinoma cells. Compound (VIIIa) exhibits moderate activity against PC-3 cells and compound (VIIIb) demonstrates the highest antiproliferative effect against HeLa cells. -(SHAW*, A. Y.; CHANG, C.-Y.; LIAU, H.-H.; LU, P.-J.; CHEN, H.-L.; YANG, C.-N.; LI, H.-Y.; Eur.
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