Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

Abstract

Three new diterpene alkaloids, tangutidines A–C (1–3), and four known alkaloids (4–7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1–3) were obtained for the first time. The structures of 1–3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities. Graphic Abstract

Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities

“…Hetidine-type C20-DAs possess an additional C14-C20 bond, distinguishing them structurally from the atisine class. Eleven new members (218-228) have been classified as such [65,81,84,85,90,91]. Compounds 218-219, 221, 223, and 225-226 all feature a typical exocyclic double bond characteristic of C20-DAs, while compounds 220, 222, and 224 exhibit a distinct intra-ring double bond between C15 and C16.…”

“…Stapf whole plant [92] 220 Tangutidine E Aconitum tanguticum (Maxim.) Stapf whole plant [92] 221 Paradoxine Delphinium paradoxum Bunge aerial part [91] 222 Tangutidine A Aconitum tanguticum whole plant [90] 223Tangutidine B Aconitum tanguticum whole plant[90]…”