Substitutos cutâneos: conceitos atuais e proposta de classificação

Abstract

Ferreira MC et al. Skin substitutes: current concepts and a new classification system Substitutos cutâneos: conceitos atuais e proposta de classificação ABSTRACT Complex wounds are characterized by complete loss of cutaneous cover. The most common plastic surgery technique is the autogenous skin graft; however, the amount of material available from donor areas is often limited. The development of synthetic or biological products as skin substitutes is therefore an area of interest. The present study aimed to clas sify the different types of skin substitutes available based on three criteria: the skin la yer to be replaced, which can be categorized into epidermal (E), dermal (D), and dermalepi dermal composites (C); the durability in the wound bed, which can be temporary (T) or permanent (P); and the origin of the material, subdivided into biological (b), biosynthetic (bs), and synthetic (s).

Advances in Skin Regeneration Using Tissue Engineering

“…Other commercial skin substitutes such as Apligraf TM , Celaderm TM , Dermagraft TM , Trancyte TM , and OrCel TM (Figure 3), are constructed from sheets of cells derived from neonatal (allogenic) foreskin [19,63,92,93]. TransCyte™ has similar configuration to Biobrane ® and consists of a nylon mesh seeded with fibroblasts cultured from neonatal human foreskin.…”

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

“…However, some events 2 can lead to tissue loss and cause wounds, which constitutes a break in the continuity of a corporal tissue 3 , whose causes are: physical, chemical or mechanical traumas among others. In this context, there is stimulation of the organism's defense and the beginning of the cicatrization, which consists in reconstructing the injured site, in order to restore the integrity and normal function 4 , besides being complex and dynamic, and involving biochemical and physiological events, which must act in harmony for the benefit of tissue restoration 5,6. However, the complex process of tissue cicatrization can be influenced, it may not occur in a successful manner and it has long been an object of study concerning the factors that affect it.…”

Estudo comparativo de matrizes dérmicas de colágeno bovino com e sem lâmina de silicone no tratamento da contratura cicatricial pós-queimadura - Análise clínica e histológica

“…Iniciaram-se então pesquisas para se desenvolver coberturas alternativas 11 , que resultaram no surgimento dos substitutos cutâneos, grupo heterogêneo de elementos biológicos e/ou sintéticos que possibilitaram a oclusão temporária ou permanente das feridas 12 .…”