Subcutaneous Fat Necrosis Associated With Pancreatic Disease

Hughes, Philip S. H.

doi:10.1001/archderm.1975.01630160096013

Cited by 91 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surrounding the focal fat necrosis, an acute inflammatory infiltrate can be seen. Later, granulomatous changes contribute to the picture of a lobular panniculitis [3, 11, 12, 13]. Outside of the subcutaneous tissue, periarticular fat necrosis may lead to arthritis [8].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pancreatic Panniculitis in an 88-Year-Old Man with Neuroendocrine Carcinoma

Preiß

Faiss²,

Loddenkemper

et al. 2002

Digestion

View full text Add to dashboard Cite

Pancreatic panniculitis is a rare complication that occurs in 0.3–3% of patients with pancreatic diseases. Most of the cases reported to date were associated with adenocarcinoma and acute or chronic pancreatitis. We here present an 88-year-old man who was admitted to our institution with a nonfunctional neuroendocrine carcinoma of the pancreas. He subsequently developed pancreatic panniculitis and arthritis. Treatment with octreotide did not have an effect neither on progression of the carcinoma nor on development of new skin lesions. Two months after the diagnosis of pancreatic panniculitis had been made, the patient died from progressing carcinoma. A review of the literature shows that there is no congruent hypothesis for the pathogenesis of pancreatic panniculitis. Vascular damage seems to induce lipolysis by pancreatic enzymes. This eventually leads to fat necrosis. The diversity of disorders that can go along with pancreatic panniculitis suggests an unspecific damage of pancreatic tissue as a first step in the chain of events.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Very often, the cutaneous manifestation precedes the pancreatic disease [16]. The underlying disorders can be acute [17]and chronic pancreatitis [12], pseudocysts [8], pancreatic duct stenosis [18], abdominal trauma [15]or pancreatic carcinoma [6]. …”

Section: Discussionmentioning

confidence: 99%

Pancreatic Panniculitis in an 88-Year-Old Man with Neuroendocrine Carcinoma

Preiß

Faiss²,

Loddenkemper

et al. 2002

Digestion

View full text Add to dashboard Cite

show abstract

“…Hence lipase can hydrolyze neutral fatty acids into glycerol and free fatty acids, which leads to fat necrosis. This hypothesis is supported on the basis that more than 50% of the patients with a pancreatic portal fistulization develop panniculitis [9, 10]. …”

Section: Discussionmentioning

confidence: 99%

Panniculitis Caused by Acinous Pancreatic Carcinoma

Heykarts¹,

Anseeuw²,

Degreef³

1999

Dermatology

View full text Add to dashboard Cite

show abstract

“…

Panniculitis • Pancreatic diseasePancreatic panniculitis is associated with pancreatic diseases of inflammatory, traumatic or malignant origin [1,2], Clinically it con sists of tender and painful nodules that frequently appear on the legs but can also be present on the trunk, arms and scalp ( 1],We report a case of pancreatic panniculitis with a single cutaneous nodule that appeared almost simultaneously with abdominal symp toms.A 57-year-old woman with a papillary thyroid carcinoma and lung métastasés suffered from acute epigastric pain with vomiting and malaise. On hospital admission, white blood cell count and serum amylase levels were elevated.

…”

mentioning

confidence: 99%

“…The relationship between panniculitis and evolution of pancreatic disease is variable. A link between blood levels of amylase and the onset of the subcutaneous nodules has been made (2,3], but the pathogenesis is still unknown. Subcutaneous fat necrosis as manifestation of pancreatitis was recog nized as long ago as 1889. when 2 cases were first reported [4.5].…”

mentioning

confidence: 99%