Panniculitis Caused by Acinous Pancreatic Carcinoma

Heykarts, B; Anseeuw, M; Degreef, Hugo

doi:10.1159/000018107

Cited by 41 publications

(23 citation statements)

References 8 publications

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“…[7] There has been some success reported with the administration of octreotide acetate, a synthetic polypeptide that inhibits pancreatic enzyme production. [91016] In addition, general supportive measures, including rest, elevation of the legs, compression stockings, and nonsteroidal anti-inflammatory drugs, may be helpful.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic panniculitis in a child

Rao

Danturty

2010

Indian J Dermatol

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Pancreatic panniculitis is an uncommon cause of panniculitis. It is associated with acute or chronic pancreatic disease. 1½ year old boy was referred for erythematous tender nodules involving both legs and associated with abdominal distention, fever, and vomiting. Dermatological examination revealed multiple erythematous tender nodules distributed over front and back of legs. Blood chemistry showed raised serum amylase (430 IU/ 1). Ultrasonography showed a pseudopancreatic cyst. Multislice CT scan was suggestive of a pseudopancreatic cyst. A skin biopsy showed typical features of pancreatic panniculitis which included lobular panniculitis with lipocyte degeneration with few Ghost cells.

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Section: Discussionmentioning

confidence: 99%

Pancreatic panniculitis in a child

Rao

Danturty

2010

Indian J Dermatol

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“…Most tumorassociated cases of pancreatic fat necrosis have occurred in association with acinar-cell carcinoma. [13][14][15][16][17][18] These rare tumors occur in elderly patients of either sex and account for approximately 1 percent of exocrine pancreatic neoplasms, although it has been estimated that they may be responsible for more than 80 percent of neoplastic cases of this syndrome. 9 Most pancreatic carcinomas are believed to arise from ductal cells that are nonfunctional in terms of pancreatic enzyme production.…”

Section: Fat Necrosis and Pancreatic Diseasementioning

confidence: 99%

Case 37-2002

Ashley¹,

Lauwers²

2002

N Engl J Med

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A 69-year-old man was admitted to the hospital because of painful cutaneous nodules, elevated lipase levels, and abnormal results on abdominal scanning.The patient had been in stable health until 15 weeks earlier, when pain developed in his feet. Two weeks later, articular examination showed firm, nonpitting edema of both ankles and pain on compression of the pedal arches bilaterally. The urine was trace-positive for glucose. The results of laboratory tests are shown in Table 1. The levels of uric acid, total protein, albumin, globulin, aspartate aminotransferase, and alanine aminotransferase were normal. The pattern on serum protein immunoelectrophoresis was normal, and the levels of IgG, IgA, and IgM were normal. A test for antinuclear antibodies was positive at 1:160, with a speckled pattern, and a test for rheumatoid factor was negative. On chest radiography, there was evidence of a previous median sternotomy; there was also stable bilateral pleural thickening, believed to have resulted from exposure to asbestos while the patient was employed years earlier aboard aging maritime ships. The lungs were clear, and the size of the heart was normal.The pain in the feet improved, but pain in all the fingers developed and was relieved to varying degrees *To convert the values for glucose to millimoles per liter, multiply by 0.05551.

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“…Intramedullary fat degradation results in osteolytic bone lesions. Other potential complications are polyserositis [4], submucosal necrosis in the gastrointestinal tract or ascites, respectively [2,9]. Arthritis mostly affects ankles, but also knees, metacarpal joints, wrists, elbows or other joints [4].…”

mentioning

confidence: 99%

“…Subsequent inflammation and vessel damage allows degrading enzymes to infiltrate the subcutaneous fat tissue [2,5]. Amylase and lipase cause fat degradation resulting in saponification of neutral fat by hydrolysis into glycerol and free fatty acids, forming calcium soap [5,9]. Subsequent Figure 2 Pancreatic panniculitis predominantly affects the lobules and is characterized by subcutaneous fat necrosis (hematoxylin-eosin stain, original magnification x 25) (a).…”

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confidence: 99%

Panniculitis due to pancreatic disease

Lengfeld

Kneitz

Goebeler

et al. 2015

J Deutsche Derma Gesell

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Wir berichten über einen 54-jährigen Patienten, der sich mit schmerzhaften Knötchen an den Armen und Beinen vorstellte, die sich vier Tage zuvor ausgebildet hatten (Abbildung 1a, b). Er klagte über Fieber und Knieschmerzen. Zehn Tage zuvor war er wegen einer akuten Pankreatitis in die Medizinische Klinik stationär aufgenommen worden. Eine Sonographie des Abdomens zeigte keine pathologischen Veränderungen, in der Magnetresonanztomografie stellte sich jedoch eine Pankreatitis dar. Der Patient verneinte übermäßigen Alkoholkonsum, berichtete aber über eine bereits fünf Jahre zuvor diagnostizierte Pankreatitis. Als weitere Komorbiditäten bestanden ein Bluthochdruck mit Linksherzhypertrophie, Vorhofflimmern und eine Refluxösophagitis. In der Labordiagnostik zeigten sich erhöhte Werte für Lipase (7231 U/l), Amylase (1036 U/l) und Lactatdehydrogenase (828 U/l); GOT, GPT sowie γ-GT waren jedoch nur leicht erhöht. Eine Eosinophilie lag nicht vor. Wir stellten die klinische Verdachtsdiagnose einer pankreatischen Pannikulitis und entnahmen eine Hautbiopsie vom rechten Oberschenkel. Die Histologie zeigte eine InteressenkonfliktKeiner.

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Panniculitis Caused by Acinous Pancreatic Carcinoma

Cited by 41 publications

References 8 publications

Pancreatic panniculitis in a child

Pancreatic panniculitis in a child

Case 37-2002

Panniculitis due to pancreatic disease

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