Single-Nodule Pancreatic Panniculitis

Sánchez, M. Herrera; Fernández, Rafael Ramos; Gomez-Calcerrada, M. R.

doi:10.1159/000246264

Cited by 12 publications

(2 citation statements)

References 2 publications

(3 reference statements)

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“…The nodules are usually painful (spontaneously or with minimal traumatisms), although in some patients they can be asymtomatic. 13 Cases of pancreatic panniculitis presenting with a single subcutaneous nodule have been reported, 19 such as four of our patients. Nodules generally do not breakdown and tend to involute in weeks, leaving an atrophic hyperpigmented scar.…”

Section: Discussionmentioning

confidence: 61%

Pancreatic panniculitis revisited: A series of 34 patients

Seguí,

Rodríguez‐Jiménez,

Fraga

et al. 2023

J Cutan Pathol

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BackgroundPancreatic panniculitis is a rare form of panniculitis generally associated with acute or chronic pancreatitis, and less frequently with pancreatic carcinoma. Clinically, it presents with subcutaneous nodules usually located in the lower extremities, however, it presents an almost pathognomonic histopathological finding with enzymatic fat necrosis in the adipose tissue.MethodsIn this retrospective case series of five hospitals, biopsy specimens of cutaneous lesions of pancreatic panniculitis were reviewed. Clinical information was obtained through medical records.ResultsA total of 34 cases were included, 23 women and 11 men, aged between 31 and 92 years. The most common associated pancreatic disease was acute pancreatitis (23 cases) and its main triggering cause was gallstones (17 cases). In two patients it was related to chronic pancreatitis and six cases were associated with malignancy. Histopathological findings were always the key to diagnosis. In the biopsies reviewed, mostly lobular panniculitis with the characteristic necrosis of the adipocytes was observed. In addition, nine of the cases presented with Splendore–Hoeppli phenomenon.ConclusionsWe present the largest series of pancreatic panniculitis. Clinically, the female predominance and biliary lithiasis as the main cause of acute pancreatitis are to be emphasized. Histopathologically, a peripheral eosinophilic striated rim surrounding aggregates of ghost adipocytes consistent with Splendore–Hoeppli is an additional clue to its diagnosis.

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Section: Discussionmentioning

confidence: 61%

Pancreatic panniculitis revisited: A series of 34 patients

Seguí,

Rodríguez‐Jiménez,

Fraga

et al. 2023

J Cutan Pathol

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show abstract

“… 2 The most common sites include distal lower extremities, particularly the ankle and pretibial area. 3 Ethanol-related pancreatitis is the most commonly reported cause, followed by pancreatic malignancies. 4 , 5 Exact pathogenesis is unknown, but trypsin may increase microcirculation permeability, leading to fat necrosis caused by circulating amylase and lipase.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Retrograde Cholangiopancreatography as a Risk Factor for Pancreatic Panniculitis in a Post-Liver Transplant Patient

Sharma

Reddy

Tan

2015

ACG Case Reports Journal

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Post endoscopic retrograde cholangiopancreatography (ERCP) pancreatic panniculitis is a rare condition caused by fat necrosis following release of pancreatic enzymes into the bloodstream. No previous reports of pancreatic panniculitis have been reported in post-liver transplant subjects undergoing ERCP. We present a 63-year-old cryptogenic cirrhotic female post-cadaveric liver transplant who underwent ERCP for suspected biliary stricture and subsequently developed pancreatic panniculitis.

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Subcutaneous Fat

Black¹,

Cunliffe²

2004

Rook's Textbook of Dermatology

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Single-Nodule Pancreatic Panniculitis

Cited by 12 publications

References 2 publications

Pancreatic panniculitis revisited: A series of 34 patients

Pancreatic panniculitis revisited: A series of 34 patients

Endoscopic Retrograde Cholangiopancreatography as a Risk Factor for Pancreatic Panniculitis in a Post-Liver Transplant Patient

Subcutaneous Fat

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