Sub-lethal toxic effects of deltamethrin on blood biochemical parameters of Japanese quail,<i>Coturnix japonica</i>

Hamidipoor, Fatemeh; Pourkhabbaz, Hamid Reza; Banaee, Mahdi; Javanmardi, Saeideh

doi:10.1080/02772248.2015.1093131

Cited by 16 publications

(8 citation statements)

References 23 publications

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“…Our results indicated that treatment with cis -BF increased TG and cholesterol levels in the plasma of Xenopus. It has been reported that high TG and cholesterol were two risk factors for multiple diseases, including obesity, stroke, cardiovascular diseases, and heart disease. , Similar to our results, previous studies on Wistar rats and Japanese quail reported that treatment with pyrethroids could increase the blood lipid levels in rodent and bird species. , In addition, we also measured the contents of cholesterol transport-related lipoprotein HDL and LDL. HDL could help remove extra cholesterol by carrying it to the liver for metabolization or excretion, reducing the risk of atherosclerosis, heart disease, and stroke .…”

Section: Discussionsupporting

confidence: 89%

Lipid Metabolic Disorder Induced by Pyrethroids in Nonalcoholic Fatty Liver Disease of Xenopus laevis

Liu

et al. 2022

Environ. Sci. Technol.

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Pyrethroids, an effective and widely used class of pesticides, have attracted considerable concerns considering their frequent detection in environmental matrices. However, their potential health risks to amphibians remain unclear. In our study, female Xenopus laevis were exposed to 0, 0.06, and 0.3 μg/L typical pyrethroid, cis-bifenthrin (cis-BF), for 3 months. Elevated activities of both aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed, indicating an ongoing liver injury. Furthermore, exposure to cis-BF led to hyperlipidemia and lipid accumulation in the liver of Xenopus. The targeted lipidomic analysis further revealed that treatment with cis-BF perturbed liver steroid homeostasis, as evidenced by the enriched lipids in the steroid biosynthesis pathway. Consistent with the targeted lipidomic result, treatment with cis-BF changed the liver transcriptome profile with induction of 808 and 1230 differentially expressed genes. Kyoto Encyclopedia of Genes and Genomes analysis underlined the adverse effects of cis-BF exposure on steroid biosynthesis, primary bile acid biosynthesis, and the PPAR signaling pathway in the Xenopus liver. Taken together, our study revealed that exposure to cis-BF at environmentally relevant concentrations resulted in lipid metabolic disorder associated with nonalcoholic fatty liver disease of X. laevis, and our results provided new insight into the potential long-term hazards of pyrethroids.

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Section: Discussionsupporting

confidence: 89%

Lipid Metabolic Disorder Induced by Pyrethroids in Nonalcoholic Fatty Liver Disease of Xenopus laevis

Liu

et al. 2022

Environ. Sci. Technol.

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“…Literature referring to low, sub-lethal doses of pesticides in birds is rare (e.g., Eason & Spurr 1995, Butler 2014, Hamidipoor et al 2015, whereas the tendency to describe cases of fatal poisoning dominates (e.g., Muzinic 2007, Hong et al 2018. Interpretation of low pesticide concentrations in some individuals in the present study may suggest a certain often-overlooked issue.…”

Section: Discussionmentioning

confidence: 55%

A pesticide banned in the European Union over a decade ago is still present in raptors in Poland

et al. 2020

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Summary The prevalent pesticide carbofuran was banned in the European Union (EU) in 2008; however, the extent of its actual elimination from the environment has been little studied. The presence of this pesticide in the livers of the protected raptors the white-tailed eagle (Haliaeetus albicilla) and the common buzzard (Buteo buteo) was monitored in Poland from 2008 to 2019 using liquid chromatography with tandem mass spectrometry analysis and data from government institutions. Carbofuran residues were detected in the liver samples of the analysed raptors throughout the period studied. In total, carbofuran was detected in the livers of 33% of the eagles and 54% of the buzzards; concentrations were in the ranges of 11–699 and 14–1890 μg kg–1 of dry matter, respectively. Effective measures to eliminate banned pesticides from the market more efficiently are required.

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“…Hematological changes have been considered good indicators of the health of fish, and are strongly related to the way fish respond to the environmental variations; thus they constitute an ideal tool for in vitro or in situ toxicological studies (Al-Akel and Shamsi 2000;Cicero, Barrella, and Rotundo 2014;Hamidipoor et al 2015;Seriani, Franca, et al 2015). Hematological changes also indicate physiological adjustments, because of changes in respiratory activity associated with pH of water, temperature, salinity, dissolved oxygen, respiratory metabolism, age, sex, body length, weight, and seasonal variations.…”

Section: Introductionmentioning

confidence: 99%

Differential blood counting in fish as a non-destructive biomarker of water contamination exposure

Corrêa

Abessa

Santos

et al. 2016

Toxicological & Environmental Chemistry

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Differential white blood cell counting was performed on blood from the fish species Oreochromis niloticus and was used as an in situ indicator of the species' exposure to contamination. Ten young fish were collected in an area influenced by the discharge of effluents and from a fish farm (control group). The fish were anesthetized and caudal puncture was used to collect the blood. Differential white blood cell counting was performed, as well as the counting of total leukocytes and thrombocytes (in 2000 cells). Physicochemical parameters of the water from both sites were analyzed. The water from the polluted area was found to have high conductivity and low levels of dissolved oxygen, factors that indicate poor environmental quality. Fish collected from the polluted site presented higher percentages of eosinophils and monocytes and fewer thrombocytes because of exposure to pollution and hypoxic conditions. The differential white blood cell count represents a suitable biomarker of environmental health and provides a tool for biomonitoring water quality.

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Sub-lethal toxic effects of deltamethrin on blood biochemical parameters of Japanese quail,Coturnix japonica

Cited by 16 publications

References 23 publications

Lipid Metabolic Disorder Induced by Pyrethroids in Nonalcoholic Fatty Liver Disease of Xenopus laevis

Lipid Metabolic Disorder Induced by Pyrethroids in Nonalcoholic Fatty Liver Disease of Xenopus laevis

A pesticide banned in the European Union over a decade ago is still present in raptors in Poland

Differential blood counting in fish as a non-destructive biomarker of water contamination exposure

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