Study on the prevalence of human papillomavirus in the anal canal of women with cervical intraepithelial neoplasia grade III

Véo, Carlos Augusto Rodrigues; Saad, Sarhan Sydney; Nicolau, Sérgio Mancini; Melani, Armando Geraldo Franchini; Denadai, Marcos Vinicius Araújo

doi:10.1016/j.ejogrb.2008.02.024

Cited by 25 publications

(14 citation statements)

References 17 publications

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“…These findings are in agreement with recent studies that reported a high prevalence of anal HPV infection in women with a cervical infection [25,35,36]. This association between the presence of cervical and anal HPV was identified both by hybrid capture and by PCR.…”

Section: Discussionsupporting

confidence: 83%

Agreement between Methods for Diagnosing HPV-Induced Anal Lesions in Women with Cervical Neoplasia

Heráclio

Souza²,

Pinto³

et al. 2011

Acta Cytologica

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Objective: To evaluate agreement between 3 methods for screening anal intraepithelial lesions: anal cytology, anoscopy and human papillomavirus (HPV) detection by PCR. Study Design: This prospective, cross-sectional study screened 324 women with cervical neoplasia for anal neoplasia. Agreement between methods was calculated using the ĸ coefficient. Results: Of 324 anal cytologies performed, 31.5% (n = 102) were found to be abnormal: low-grade anal lesions were detected in 19.1% (n = 62) of cases, high-grade lesions in 3.1% (n = 10) and atypical squamous cells of undetermined significance in 9.3% (n = 30). With respect to the biopsies, 25.7% (n = 20) were positive, consisting of 7 cases of HPV infection, 5 anal intraepithelial neoplasia (AIN) grade 1, 6 AIN grade 2, and 2 AIN grade 3. Twenty-one samples (6.5%) were inadequate for HPV analysis. Of the 303 adequate samples, 84.2% (n = 255) tested positive for HPV. Agreement between cytology and anoscopy was fair (ĸ = 0.31). Agreement between PCR for HPV and cytology was slight (ĸ = 0.08) and no agreement was found between PCR for HPV and anoscopy (ĸ = 0.00). Conclusion: Agreement between the different methods of diagnosing HPV-induced anal lesions is slight to fair; however, anal cytology permits identification of cases in which lesions are present, allowing them to be referred for anoscopy and biopsy.

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Section: Discussionsupporting

confidence: 83%

Agreement between Methods for Diagnosing HPV-Induced Anal Lesions in Women with Cervical Neoplasia

Heráclio

Souza²,

Pinto³

et al. 2011

Acta Cytologica

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“…In accordance with these findings, Véo et al (13) used hybrid capture to search for low and high-risk HPV in the anal and genital regions of 80 women and found out that, in a group of women with CIN-II or III in the genital region, incidence of HPV in the anus was 35%, against 10% in control group. Furthermore, high-risk HPV was detected in 22.5% of the women in study group against 5% in control group.…”

Section: Dst -J Bras Doenças Sex Transm 2013;25(3):145-149mentioning

confidence: 80%

Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?

Filho¹,

Eleutério²,

Dias³

et al. 2013

J Bras Doenças Sex Transm

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Introduction: There seems to be a fairly close relationship between genital and anal lesions associated with human papillomavirus (HPV) and with the pathogenesis of malignancies in such sites. Objective: This review seeks to analyze published papers that suggest the necessity for anal intraepithelial lesions screening in women with HPV genital intraepithelial lesions. Methods: A systematic review of original research published between 2001 and 2014 was performed in the databases PubMed, HighWire, Cochrane Library and Google Scholar. The keywords for the search were: "screening" or "early detection of cancer" and "anus" or "anus diseases" or "neoplasms anus" and "woman" or "women" and "HPV" or "DNA probes, HPV". Results: 1,203 articles were selected in the first search. After the reviewers applied exclusion and inclusion criteria and analyzed the papers, 15 were selected to compose this review. Most of them showed higher rates of anal intraepithelial lesions in women with genital intraepithelial lesions than in regular women. We also found a correlation between genital neoplasms and anal infection by oncogenic HPV types and the role of the virus in the pathogenesis of anal cancer. Conclusion: Screening for anal lesions in women with HPV genital lesions should be indicated, and further studies are required to determine the best methods.

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“…Em pacientes sem imunodeficiências, entretanto, essa associação ainda não está esclarecida, o que pode contribuir para a falta de normas adequadas para diagnosticar o HPV e prevenir o câncer de ânus [4][5][6] . A frequência do câncer de ânus antes considerada baixa encontra-se atualmente em elevação considerá-vel, principalmente o carcinoma de células escamosas (CCE).…”

Section: Introductionunclassified

Diagnóstico de HPV anal em mulheres com NIC: prevenção de câncer do ânus?

Capobiango

Filho²,

Afonso³

2009

Rev bras. colo-proctol.

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Trabalho realizado no Programa de Pós-Graduação em Ciências Aplicadas à Cirurgia e à Oftalmologia da Faculdade de Medicina da Universidade Federal de Minas Gerais. Recebido em 23/02/2009 Aceito para publicação em 20/04/2009 INTRODUÇÃOA infecção pelo papilomavírus humano (HPV) acomete pessoas de qualquer idade, embora seja mais comum em jovens, provavelmente devido a mais atividade sexual nesse período. Sua associação com o ví-rus da imunodeficiência adquirida pode atingir 62% dos casos 1 .A associação entre HPV de alto risco e neoplasia de ânus em homens e mulheres com imunodeficiência ou imunossupressão está confirmada e as medidas relacionadas à vigilância estão padronizadas 1-3 . Em pacientes sem imunodeficiências, entretanto, essa associação ainda não está esclarecida, o que pode contribuir para a falta de normas adequadas para diagnosticar o HPV e prevenir o câncer de ânus [4][5][6] . A frequência do câncer de ânus antes considerada baixa encontra-se atualmente em elevação considerá-vel, principalmente o carcinoma de células escamosas (CCE). Concomitantemente a esse fato, tem sido constatado o aumento das infecções anogenitais por papilomavírus humano, que acomete 20% da população mundial sexualmente ativa 7 . A relação causal entre esse vírus e o câncer do colo do útero e do ânus

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Study on the prevalence of human papillomavirus in the anal canal of women with cervical intraepithelial neoplasia grade III

Cited by 25 publications

References 17 publications

Agreement between Methods for Diagnosing HPV-Induced Anal Lesions in Women with Cervical Neoplasia

Agreement between Methods for Diagnosing HPV-Induced Anal Lesions in Women with Cervical Neoplasia

Is screening for anal squamous intraepithelial lesions in women with genital human papillomavirus intraepithelial lesions necessary?

Diagnóstico de HPV anal em mulheres com NIC: prevenção de câncer do ânus?

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