Study on the Mechanism of Antibiotic Resistance

Duceac, Letiția Doina; Ţarcă, Elena; Ciuhodaru, Mădălina Irina; Tantu, Marinela Monica; Goroftei, Roxana Elena Bogdan; Banu, Elena Ariela; Damir, Daniela; Głód, M; Luca, Alina Costina

doi:10.37358/rc.19.1.6881

Cited by 15 publications

(15 citation statements)

References 16 publications

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“…Although antibiotics are considered to be the most effective method of fighting against infections, their empirical, indiscriminate, prolonged, or incorrect usage contributes significantly to the selection of MDR strains [16,17]. Antimicrobial resistance (AMR) is a serious threat to public health and patient safety in Europe, leading to mounting healthcare costs, patient treatment failure, and deaths [11,18,19].…”

Section: Resultsmentioning

confidence: 99%

Bacterial Isolates from Endotracheal Aspirates and their Antimicrobial Resistance Pattern in Patients from Intensive Care Unit

Golli¹,

Niţu²,

Bălăşoiu³

et al. 2019

Rev. Chim.

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The emergence of multidrug-resistant (MDR) pathogens, especially for intensive care unit (ICU) patients is a serious threat to public health. To determine the frequency and antibiotic resistance pattern of bacterial pathogens isolated from tracheal aspirates of the patients admitted in ICU. The retrospective study included endotracheal aspirates from 734 patients admitted to the ICU, from January to December 2017. The analysis of the resistance patterns for the action of the appropriate antibiotics was performed using Vitek 2 Compact system and diffusion method. A total of 985 bacterial isolates were obtained, of which 227 strains of Klebsiella spp. (23.04%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (170- 17.25%), MRSA (134- 13.60%). Isolation rates indicates a higher value for male patients and elderly patients (over 65 years), statistically significant. High rates of MDR were found for Klebsiella spp. (70.04%) and Pseudomonas aeruginosa (66.25%) while almost all of the isolated NFB strains were MDR (98.82%). The study revealed high rates of MDR pathogens in the majority of ICU isolates which may be due to unnecessary use of higher generations of antibiotics, use of mechanical devices, age, comorbidities, and can determine a higher rate of morbidity and mortality among these patients.

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Section: Resultsmentioning

confidence: 99%

Bacterial Isolates from Endotracheal Aspirates and their Antimicrobial Resistance Pattern in Patients from Intensive Care Unit

Golli¹,

Niţu²,

Bălăşoiu³

et al. 2019

Rev. Chim.

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“…According to the European Antimicrobial Resistance Surveillance Network (EARS-Net), Improving Patient Safety in Europe (IPSE) and ECDC data, Romania is one of the South-Eastern European countries with one of the highest prevalence rates of MDR pathogens [10,11].…”

mentioning

confidence: 99%

The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

Golli¹,

Niţu²,

Bălăşoiu³

et al. 2019

Rev. Chim.

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To determine the resistance pattern of bacterial pathogens involved in infections of the patients aged between 18-64 years, admitted in a ICU from a 1518-bed university-affiliated hospital. A retrospective study of bacterial pathogens was carried out on 351 patients aged between 18-64 years admitted to the ICU, from January to December 2017. In this study there were analysed 469 samples from 351 patients (18-64 years). A total of 566 bacterial isolates were obtained, of which 120 strains of Klebsiella spp. (35.39%%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (75- 22.12%), Acinetobacter spp. (53 - 15.63%), Pseudomonas aeruginosa and Proteus (51 - 15.04%), and Escherichia coli (49 - 14.45%). The most common isolates were from respiratory tract (394 isolates � 69.61%). High rates of MDR were found for Pseudomonas aeruginosa (64.70%), MRSA (62.65%) and Klebsiella spp. (53.33%), while almost all of the isolated NFB strains were MDR (97.33%). There was statistic difference between the drug resistance rate of Klebsiella and E. coli strains to ceftazidime and ceftriaxone (p[0.001), cefuroxime (p[0.01) and to cefepime (p[0.01). The study revealed an alarming pattern of antibiotic resistance in the majority of ICU isolates.

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“…Thus, the wire -composite resin splint has an interface between two materials with different modules of elasticity (stainless steel and composite resin) without chemical adhesion. Thus, in this area fracture initiation may occur, because the splint exhibits low fatigue strength [16,25].…”

Section: Resultsmentioning

confidence: 99%

“…While the clinical rational for splinting is less disputable in current scientific literature [16][17][18][19][20][21], the latest advances in splinting materials and the wide variety available [22] can create confusion among practitioners. There is even less information regarding the biomechanical response of the periodontal complex in the context of different bone resorptions and splints [23][24][25][26][27][28][29][30][31][32][33]. These aspects make splinting therapy to be a challenging decision for dental professionals.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study Regarding the Biomechanical Behaviour of Bone, Fibre Reinforced Polymer and Wire Composite Perio-dontal Splints. Model Analysis

Vieriu¹,

Taculescu²,

Mocanu³

et al. 2020

Mater. Plast.

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This paper is the second part of a study regarding the biomechanical behaviour of mandibular bone in the context of different periodontal splinting systems, occlusal forces and load distributions. Electric resistive tensometry method was used to measure the strains developed in mandibular bone replica. The tests were carried out on six mandibular acrylic models, each with 8 natural teeth. The experimental groups were defined corresponding to the bone condition and splint type: normal height bone; bone resorption without splint; bone resorption and wire-composite splint; bone resorption and polyethylene fiber-reinforced composite splint. Each sample was subjected to three similar loading cycles, the force being applied successively on four incisors, two central incisors and canines, and the specific deformation values were read for four loading forces: 30 N, 50 N, 100 N and 150 N. In case of bone loss, the bone deformations are up to 110%. Periodontal splinting redistribute forces, reducing incisors bone strains associated with a slight increase in canine bone strains.

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Study on the Mechanism of Antibiotic Resistance

Cited by 15 publications

References 16 publications

Bacterial Isolates from Endotracheal Aspirates and their Antimicrobial Resistance Pattern in Patients from Intensive Care Unit

Bacterial Isolates from Endotracheal Aspirates and their Antimicrobial Resistance Pattern in Patients from Intensive Care Unit

The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

In Vitro Study Regarding the Biomechanical Behaviour of Bone, Fibre Reinforced Polymer and Wire Composite Perio-dontal Splints. Model Analysis

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