The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

Golli, Andreea-Loredana; Niţu, Floarea Mimi; Bălăşoiu, Maria; Lungu, Marina Alina; Dragomirescu, C; Olteanu, Mădălina; Nemeș, Roxana Maria; Tantu, Monica Marilena; Olteanu, Mihai

doi:10.37358/rc.19.5.7214

Cited by 7 publications

(10 citation statements)

References 24 publications

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“…In other studies conducted with the aim of highlighting the MDR strains which caused other types of infections besides BSI, Klebsiella ranks first among isolated microorganisms, 12 , 14 , 15 with the same findings in other researchers’ studies. 16 …”

Section: Discussionsupporting

confidence: 73%

Prevalence of Multidrug-Resistant Pathogens Causing Bloodstream Infections in an Intensive Care Unit

Golli¹,

Cristea²,

Zlatian³

et al. 2022

IDR

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Introduction Bloodstream infections are the most severe infections that cause the highest mortality rate, especially in patients admitted to the intensive care unit (ICU). In this study, we aimed to analyze the distribution, resistance patterns and prevalence of MDR (multidrug-resistant) pathogens isolated in blood samples collected from patients with severe invasive infections hospitalized in the ICU. Methods A retrospective study of bacterial pathogens was performed on 490 patients admitted to the ICU between 2017 and 2020. The resistance patterns were analyzed using Vitek 2 Compact system. Results In total, 617 bacterial isolates were obtained. Four hundred and twenty-seven isolates (69.21%) were Gram positive and 190 isolates (30.79%) were Gram negative bacteria. The most frequently isolated micro-organisms identified in the blood samples for the entire period (2017–2020) were Coagulase-negative staphylococci (CoNS) (318–51.54%), followed by Klebsiella pneumoniae (70–11.34%), Methicillin-Resistant Staphylococcus aureus (MRSA) (58–9.40%), Acinetobacter baumannii (45–7.29%) and Enterococcus faecalis (42–6.80%). The number of Klebsiella pneumoniae strains significantly increased in 2020, compared to the previous year (p < 0.05). The Acinetobacter baumannii prevalence was significantly higher in the age group of 20–64 years (10.89%) and over 65 years (3.53%) (p < 0.001). The difference between the prevalence of CoNS in the elderly (67.84%) and in adults (20–64 years) (52.47%) was also statistically significant (p < 0.001). High rates of MDR were found for Acinetobacter baumannii (97.77%), Pseudomonas aeruginosa (65%), Klebsiella pneumoniae (50%), Enterococcus faecalis (47.61%) and MRSA (46.55%). More than 60% of the Klebsiella pneumoniae strains were found to be resistant to carbapenems. Conclusion The study revealed an alarming prevalence of MDR strains isolated in blood samples of the patients admitted to the ICU, indicating the necessity of consistent application of the measures to control.

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Section: Discussionsupporting

confidence: 73%

Prevalence of Multidrug-Resistant Pathogens Causing Bloodstream Infections in an Intensive Care Unit

Golli¹,

Cristea²,

Zlatian³

et al. 2022

IDR

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“…Although antibiotics are considered to be the most effective method of fighting against infections, their empirical, indiscriminate, prolonged, or incorrect usage contributes significantly to the selection of MDR strains [16,17]. Antimicrobial resistance (AMR) is a serious threat to public health and patient safety in Europe, leading to mounting healthcare costs, patient treatment failure, and deaths [11,18,19].…”

Section: Resultsmentioning

confidence: 99%

“…A worrying phenomenon in Romania is also the existence of the MDR-TB and XDR-TB cases in socioeconomic conditions (malnutrition, agglomeration, stress), with the doubling of number of cases of XDR-TB in the last years, including the cases of extrapulmonary tuberculosis which originates from the hematogenous metastatic affects developed during the prime TB infection period [28][29][30] All these observations are in line with the results of other studies we have conducted to identify germs involved in the production of infections in patients hospitalized in ICU. [31,32].…”

Section: Resultsmentioning

confidence: 99%

Bacterial Isolates from Endotracheal Aspirates and their Antimicrobial Resistance Pattern in Patients from Intensive Care Unit

Golli¹,

Niţu²,

Bălăşoiu³

et al. 2019

Rev. Chim.

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The emergence of multidrug-resistant (MDR) pathogens, especially for intensive care unit (ICU) patients is a serious threat to public health. To determine the frequency and antibiotic resistance pattern of bacterial pathogens isolated from tracheal aspirates of the patients admitted in ICU. The retrospective study included endotracheal aspirates from 734 patients admitted to the ICU, from January to December 2017. The analysis of the resistance patterns for the action of the appropriate antibiotics was performed using Vitek 2 Compact system and diffusion method. A total of 985 bacterial isolates were obtained, of which 227 strains of Klebsiella spp. (23.04%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (170- 17.25%), MRSA (134- 13.60%). Isolation rates indicates a higher value for male patients and elderly patients (over 65 years), statistically significant. High rates of MDR were found for Klebsiella spp. (70.04%) and Pseudomonas aeruginosa (66.25%) while almost all of the isolated NFB strains were MDR (98.82%). The study revealed high rates of MDR pathogens in the majority of ICU isolates which may be due to unnecessary use of higher generations of antibiotics, use of mechanical devices, age, comorbidities, and can determine a higher rate of morbidity and mortality among these patients.

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“…Before becoming the gold standard in the investigation of the small bowel, WCE has been extensively studied in comparison with other traditional evaluation methods, to ascertain which correctly identifies the present pathology and thus offers the best results. The use of the WCE procedure eliminates the risk of contracting an infection with multidrug-resistant germs, given the fact that Romania is one of the South-Eastern European countries with one of the highest prevalence rates of multidrug-resistant pathogens (17). Elderly patients are more susceptible to infection and complications due to the constant decline in physical function and compromised immune system (18); thus, WCE is more indicated for the diagnosis of digestive disorders in this category of patients.…”

Section: Uses For Wcementioning

confidence: 99%

Clinical impact of wireless capsule endoscopy for small bowel investigation (Review)

et al. 2022

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Wireless capsule endoscopy is currently considered the gold standard in the investigation of the small bowel. It is both practical for physicians and easily accepted by patients. Prior to its development, two types of imaging investigations of the small bowel were available: radiologic and endoscopic. The first category is less invasive and comfortable for patients; it presents the ensemble of the small bowel, but it may imply radiation exposure. Images are constructed based on signals emitted by various equipment and require special interpretation. Endoscopic techniques provide real-time colored images acquired by miniature cameras from inside the small bowel, require interpretation only from a medical point of view, may allow the possibility to perform biopsies, but the investigation only covers a part of the small bowel and are more difficult to accept by patients. Wireless capsule endoscopy is the current solution that overcomes a part of the previous drawbacks: it covers the entire small bowel, it provides real-time images acquired by cameras, it is painless for patients, and it represents an abundant source of information for physicians. Yet, it lacks motion control and the possibility to perform biopsies or administer drugs. However, significant effort has been oriented in these directions by technical and medical teams, and more advanced capsules will surely be available in the following years. Contents 1. Introduction 2. Brief history of small bowel investigation 3. A brilliant idea 4. Wireless capsule endoscopy (WCE) 5. WCE systems 6. Uses for WCE 7. The future of WCE

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The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

Cited by 7 publications

References 24 publications

Prevalence of Multidrug-Resistant Pathogens Causing Bloodstream Infections in an Intensive Care Unit

Prevalence of Multidrug-Resistant Pathogens Causing Bloodstream Infections in an Intensive Care Unit

Bacterial Isolates from Endotracheal Aspirates and their Antimicrobial Resistance Pattern in Patients from Intensive Care Unit

Clinical impact of wireless capsule endoscopy for small bowel investigation (Review)

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