Urinary tract infection (UTI) is the second most common type of infection and it may be a cause of considerable morbidity in case of recurrence. The aim of this retrospective study was to determine the distribution of pathogens involved in UTIs in hospitalized patients and their drug resistant pattern. It was analysed the distribution of the uropathogens from 427 urine samples collected from hospitalized patients from the urology clinic of County Emergency Clinical Hospital Craiova, between January to December 2017. Identification of the bacterial strains was performed on Chromagar (Oxoid) and the Vitek 2 Compact systems. The most common causative pathogens in UTIs were E. coli (45.35%), followed by Klebsiella spp., Enterococcus spp., Enterobacter spp. (8.18%). The strains of Enterobacteriaceae presented a high resistance to second and third generation cephalosporin, fluoroquinolones, and amoxicillin-clavulanic-acid. Surveillance of antibiotic prescription and monitoring studies are required to reduce the risk of drug resistance in bacterial uropathogens. RezumatInfecția tractului urinar (ITU) este al doilea cel mai frecvent tip de infecție și poate fi o cauză de morbiditate considerabilă în cazul recidivei. Scopul acestui studiu retrospectiv a fost de a determina distribuția agenților patogeni implicați în ITU la pacienții spitalizați și profilul rezistenței lor la antibiotice. A fost analizată distribuția bacteriilor uropatogene izolate din 427 eșantioane de urină recoltate de la pacienții spitalizați în clinica de Urologie a Spitalului Clinic Județean de Urgență Craiova, în perioada ianuarie-decembrie 2017. Identificarea tulpinilor bacteriene s-a făcut pe mediul chromagar (Oxoid) şi pe sistemul Vitek 2 Compact. Cei mai frecvenți agenți patogeni cauzali ai ITU au fost E. coli (45,35%), urmată de Klebsiella spp., Enterococcus spp., Enterobacter spp. (8,18%). Tulpinile de Enterobacteriaceae au prezentat o rezistență ridicată la cefalosporine de a doua și a treia generație, fluoroquinolone și amoxicilină-acid clavulanic. Supravegherea studiilor privind prescrierea antibioticelor și studiile de monitorizare sunt necesare pentru a reduce riscul de rezistență la medicamente al bacteriilor uropatogene.

To determine the resistance pattern of bacterial pathogens involved in infections of the patients aged between 18-64 years, admitted in a ICU from a 1518-bed university-affiliated hospital. A retrospective study of bacterial pathogens was carried out on 351 patients aged between 18-64 years admitted to the ICU, from January to December 2017. In this study there were analysed 469 samples from 351 patients (18-64 years). A total of 566 bacterial isolates were obtained, of which 120 strains of Klebsiella spp. (35.39%%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (75- 22.12%), Acinetobacter spp. (53 - 15.63%), Pseudomonas aeruginosa and Proteus (51 - 15.04%), and Escherichia coli (49 - 14.45%). The most common isolates were from respiratory tract (394 isolates � 69.61%). High rates of MDR were found for Pseudomonas aeruginosa (64.70%), MRSA (62.65%) and Klebsiella spp. (53.33%), while almost all of the isolated NFB strains were MDR (97.33%). There was statistic difference between the drug resistance rate of Klebsiella and E. coli strains to ceftazidime and ceftriaxone (p[0.001), cefuroxime (p[0.01) and to cefepime (p[0.01). The study revealed an alarming pattern of antibiotic resistance in the majority of ICU isolates.

Objective: The aim of the study was to assess the long-term impact of laparoscopic sleeve gastrectomy (LSG) on lipid profile, uric acid level and metabolic syndrome. Materials and methods: A prospective study was performed between 2009-2014, evaluating long-term percentage of excesso body mass index loss (%EBMIL), lipid profile, uric acid level and metabolic syndrome. Results: Overall sixty subjects were followed-up. %EBMIL increased significantly, reaching a maximum (86,9 ± 6,3%) at 5 years post-LSG. Therapeutic success rate (%EBMIL ≥ 60%) was 80% at 5 years. The triglyceride level decreased significantly (148 ± 72.1 mg/dL baseline vs 130.7 ± 57.5 mg/dL at 1 month vs 110.7 ± 42.6 mg/dL at 3 months vs 92.5 ± 35.2 mg/dL at 1 year vs 84.2 ± 32.3 mg/dL at 5 years; p < 0.05 for all). HDL-cholesterol increased and uric acid decreased significantly in the first year postoperatively, remaining stable afterwards (46.9 ± 12.3 mg/dL baseline vs 47.4 ± 10 mg/dL at 1 month vs 49.8 ± 9.3 mg/dL at 3 months vs 55.4 ± 10.2 mg/dL at 1 year; p < 0.05 for all for HDL-cholesterol and 6.4 ± 2 mg/dL baseline vs 6 ± 1.7 mg/dL at 1 month vs 5.2 ± 1.3 mg/dL at 3 months vs 4.8 ± 1 mg/dL at 1 year; p < 0.05 for all for uric acid). The prevalence of metabolic syndrome decreased from 66.7% baseline to 8.3% at 5 years postoperatively (p < 0.01). Conclusions: LSG was effective in terms of %EBMIL and metabolic traits improvement for Romanian patients.

Cancer is the second leading cause of death in Romania and worldwide. Cancer patients are at increasing risk of acquiring bacterial infection with multi-resistant germs, including multidrug-resistant (MDR) strains of Gram-negative bacteria involved in nosocomial infection. Romania is one of the South-Eastern European countries with one of the highest prevalence rates of MDR pathogens. To determine the resistance pattern of bacterial profile and antibiotic resistance pattern in cancer patients admitted at the County Emergency Clinical Hospital Craiova, Romania. A retrospective study of bacterial pathogens was carried out on 90 adult cancer patients admitted from January to December 2018. The analysis of the resistance patterns for the action of the appropriate antibiotics was performed using Vitek 2 Compact system and diffusion method. In this study there were analysed 92 samples from 90 oncological patients (37-86 years). A total of 157 bacterial isolates were obtained, of which 37 strains of Staphylococcus aureus (23.56%), followed by Streptococcus pneumoniae (23- 14.64%), Klebsiella spp. and Escherichia coli (22 - 14,01%). The most common isolates were from respiratory tract (86 isolates - 54.77%). High rates of MDR were found for E. coli (63.63%), MRSA (61,11%) and Klebsiella spp. (54,54%), while one third of the isolated strains of Pseudomonas aeruginosa, Acinetobacter spp. and Proteus spp. were MDR. The findings of this study may be the basis for further more extensive studies highlighting the germs involved in the infectious pathology of cancer patients, in order to determine the antimicrobial resistance and to improve the methods of prophylaxis and treatment. Keywords: multidrug resistance (MDR), cancer patients, bacterial pathogen