Study of Thyroid Dysfunction in Association with Infertility

Habbu, Padmini Prakash; Shaikh, Abdul Kayyum

doi:10.9734/ijbcrr/2016/24926

Cited by 7 publications

(16 citation statements)

References 7 publications

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“…In hypothyroidism low levels of fT 3 and fT 4 has a positive feedback effect on pituitary gland to enhance the release of TSH. Low fT 3 and fT 4 along with raised TSH levels 2,24 in hypothyroid infertile women was reported in hypothyroid infertile women. 13,21,28 which was similar to present findings.…”

Section: Resultsmentioning

confidence: 89%

“…They were further subdivided into clinical and subclinical groups on the basis of TSH level. 2,23 Statistical analysis was done by using SPSS version 20.0. Descriptive statistics was used to describe the nature of data and expressed as mean ± SD values while categorical variables were expressed as number (percentage).…”

Section: Methodsmentioning

confidence: 99%

“…1 Over last 30 years, infertility has become a problem but it should not be considered as a disease because the couples are healthy generally. 2 Infertility has been ranked as the fifth global disability in females. 3 It is anticipated that globally 60-80 million couples face the problem to conceive every year.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Disorders;

Rahman

Saeed

Zia

et al. 2019

TPMJ

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Infertility has been considered as a worldwide global health issue. It is a human nature that every couple wants to have children so that the relationship can become stronger. Defect in thyroid hormone levels is one of the factors which can lead to reproductive cycle disorders and thus infertility results. Objectives: The purpose of current study was to investigate the levels of thyroid hormones in primary infertile and fertile females in order to evaluate the prevalence of thyroid disordsers. Study Design: Case control study. Place of Study: Outdoor of gynecology department of Madinah Teaching Hospital, Faisalabad. Duration of Study: 6 months from July to December 2017. Material and Methods: The study enrolled total 91 females of reproductive age 20-35 years which included 45 primary infertile females and 46 fertile females. They were divided into two groups. Group I: case/primary infertile women group (n= 45) and Group II: control /fertile females group (n= 46). Data was collected by taking history and clinical examination. Hormonal profile including fT3, fT4 and TSH was done by means of chemiluminescentimmunoassay. Results were analyzed by using SPSS version 20. Results: Most of the infertile females were euthyroid and hyperthyroidism was the most common thyroid disorder. The prevalence of hypothyroidism and hyperthyroidism was about 9.3% and 26.7% respectively. The p-value showed the non-significant difference in the levels of fT3, fT4 and TSH between primary infertile and fertile females.Significant positive correlation between fT3 and fT4 while non-significant negative correlation was observed between fT3 & TSH and fT4& TSH in primary infertile females. Conclusion: Infertile females with menstrual irregularities should be advised thyroid profile in order to avoid other unnecessary investigations. Evaluation of thyroid status in the infertile couple is not only important but also easy because its treatment is very simple and often has revocable effects on subfertility.

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Section: Resultsmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

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Thyroid Disorders;

Rahman

Saeed

Zia

et al. 2019

TPMJ

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“…19 In another hospital based descriptive study conducted in Sholapur shows association of hypothyroidism with infertility in 23%. 11 Other similar study conducted for infertile women with hypothyroidism, where the response of treatment was followed up, which has shown the association of increased TSH more than 4.2 mU seen in 23.9% of cases. Out of which 76.6% conceived after treatment with thyroid hormones.…”

Section: Correlation Of Hypothyroidism With Infertilitymentioning

confidence: 94%

“…8 Recent studies conducted in 2015-2016, at Tamil Nadu and Maharashtra, concluded that the prevalence of hypothyroidism is as high as 27% among the women suffering from Abnormal uterine bleeding (AUB) and 19% are hypothyroid among infertility. [9][10][11] This present study is conducted with the objective of determining the occurrence of hypothyroidism in rural women and the correlation of hypothyroidism and reproductive health problems.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of hypothyroidism and its correlation with reproductive health problems: a cross sectional study

Kumar

Kotur

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Thyroid dysfunction is 10 times more common in women than in men. Hypothyroidism among women of reproductive age group is linked to menstrual irregularities, polycystic ovarian syndrome (PCOS), miscarriage and infertility. Several studies are available in the literature reporting regarding impact of hypothyroidism on one or the other isolated problems of reproductive health problems.Methods: This cross-sectional study is conducted including 290 participants having various reproductive health problems attending the gynaecology OPD of a rural based tertiary care hospital of Tamil Nadu during the year 2017-2018.These participants were investigated for thyroid dysfunction and its correlation of hypothyroidism with reproductive health problems viz. menstrual irregularities, Polycystic ovarian diseases (PCOS), infertility and pregnancy loss was studied.Results: It was observed that 80.6% of the 290 participants were euthyroid and 16.97% were hypothyroid, who presented with menstrual irregularities like menorrhagia (28.6%), oligomenorrhea (20.8%), amenorrhoea (21.3%), PCOS (28.6%), infertility (21.6%) and 23.8% hypothyroid women had pregnancy losses of varying number.Conclusions: In present study the occurrence of hypothyroidism was found to be 16.89%. Since hypothyroidism has close association with problems like menstrual irregularities, PCOS, miscarriages and infertility, thyroid function test should be routinely recommended for these women. Thyroid dysfunction can be corrected with simple, cost-effective treatment. This will help in improvement in pregnancy outcome and also avoid subjecting women for major surgeries for menorrhagia.

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Effects of hypothyroidism in Indian women of reproductive age group – A review article

Kumar¹,

Kotur²

2020

IJOGR

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Thyroid diseases are the commonest endocrine disorders worldwide. Thyroid dysfunction is 10 times more common in women than in men. Hypothyroidism among women of reproductive age group is linked to menstrual irregularities, polycystic ovaries, recurrent pregnancy loss and infertility The aim of the present review is to provide a comprehensive view of the literature regarding the association of hypothyroidism in reproductive age group women 15-45 years.: A literature search was performed using electronic databases like Pubmed/ Medline to identify from 2000 to 201 8. The search yielded around 18 original research articles. In Correlation of Hypothyroidism with Reproductive Health Problem, the various studies results show that menorrghia is the commonest menstrual irregularity in 27%-72%, next common menstrual irregularity is oligomenorrhea varying from 5 - 26 %. As reviewed from various other studies on association of hypothyroidism with PCOS was found to be between 21% - 32%, Hypothyroidism with Infertility was 22% - 32% and hypothyroidism with recurrent pregnancy loss was found to be 4-15%. In reproductive age women with hypothyroidism have reproductive health problems like menstrual irregularities, polycystic ovarian syndrome, miscarriages and infertility. Hence thyroid function test should be routinely recommended for all women in reproductive age as it helps in early detection of hypothyr oidism that can be treated medically with hormones and is cost-effective. Unnecessary surgery can be avoided in menstrual irregularities like menorrhagia and complications of pregnancy can be prevented which will reduce burden on the health system and society.

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Study of Thyroid Dysfunction in Association with Infertility

Cited by 7 publications

References 7 publications

Thyroid Disorders;

Thyroid Disorders;

Occurrence of hypothyroidism and its correlation with reproductive health problems: a cross sectional study

Effects of hypothyroidism in Indian women of reproductive age group – A review article

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