Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

Zárate, Alejandro; Don, Julieta; Secchi, Dante Gustavo; Carrica, A; Costa, F.; Pánico, René; Brusa, Martín; Barra, José L.; Brunotto, Mabel

doi:10.1177/1010428317699113

Cited by 14 publications

(13 citation statements)

References 25 publications

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“…Among the remaining articles, four articles (Tandle et al, 2001 ; Jing et al, 2012 ; Saleem et al, 2013 ; Nagam et al, 2017 ) were not in agreement with HWE ( P < 0.001) and three duplicated data publications were further excluded (Ji et al, 2008 ; Misra et al, 2009 ; Wang et al, 2012 ). We included 21 case-control study involving 3,525 oral carcinoma patients and 3,712 controls (Summersgill et al, 2000 ; Drummond et al, 2002 ; Nagpal et al, 2002 ; Shen et al, 2002 ; Katiyar et al, 2003 ; Kietthubthew et al, 2003 ; Hsieh et al, 2005 ; Mitra et al, 2005 ; Bau et al, 2007 ; Kuroda et al, 2007 ; Chen et al, 2008 ; Lin et al, 2008 ; Tu et al, 2008 ; Kitkumthorn et al, 2010 ; Ihsan et al, 2011 ; Saini et al, 2011 ; Patel et al, 2013 ; Adduri et al, 2014 ; Sina et al, 2014 ; Rao et al, 2017 ; Zarate et al, 2017 ). The characteristics of the selected studies are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer

et al. 2018

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Objectives: TP53 is an important tumor suppressor gene to maintain genomic integrity, and its mutations increase the susceptibility to oral carcinoma. Previous published studies have reported the relation of TP53 codon 72 polymorphism with the risk of oral carcinoma, but the results remain controversial and inconclusive.Methods: We therefore utilized meta-analysis based on a comprehensive search in PubMed, EMBASE, and Google of Scholar databases up to August 19, 2017.Results: Total 3,525 cases and 3,712 controls from 21 case-control studies were selected. We found no significant association between TP53 codon 72 polymorphism and oral carcinoma susceptibility in all genetic contrast models, including subgroup analysis based on control source and ethnicity. Furthermore, TP53 codon 72 polymorphism was not significant associated with oral carcinoma susceptibility in tobacco or alcohol use, and HPV infection status. Our results were confirmed by sensitivity analysis and no publication bias was found.Conclusions: Taken together, our data indicate that TP53 codon 72 polymorphism is not associated with the susceptibility to oral carcinoma.

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Section: Resultsmentioning

confidence: 99%

Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer

et al. 2018

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“…Finally, a total of twenty articles were rigorously included in our quantitative synthesis. Of these twenty articles, sixteen studies [ 11 – 15 , 19 – 29 ] examined oral squamous cell carcinoma (OSCC), and five studies [ 10 , 11 , 30 – 32 ] examined oral leukoplakia (OL). The basic information and genotype frequency of the included studies are listed in Additional file 3 and Additional file 4 .…”

Section: Resultsmentioning

confidence: 99%

“…Currently, the association between rs1042522 of the TP53 gene and OL/OSCC risks has been inconsistently reported among different populations. For instance, TP53 rs1042522 was reported to be associated with the risk of oral potentially malignant disorders (OPMD), including OL, in Argentine patients [ 10 ]. However, the risk of OL was not found in Taiwanese patients [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis

2018

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BackgroundThere are different and inconsistent conclusions regarding the genetic relationship between the human tumor suppressor p53 (TP53) rs1042522 polymorphism and the risk of oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL). Therefore, the aim of the study was to comprehensively reassess this association through the performance of an updated meta-analysis.MethodsAfter searching the available databases, we systematically screened and included the eligible case-control studies, which contain the full genotype frequency data of the TP53 rs1042522 polymorphism for both OSCC/OL patients and the negative control groups. PA (P-value of the association test) and ORs (odd ratios) with their corresponding 95% CIs (confidence intervals) were calculated to quantitatively evaluate the influence of TP53 rs1042522 on the susceptibility of patients to OSCC or OL.ResultsIn total, twenty eligible case-control articles were finally enrolled. Compared with the controls, no increased or decreased risk of OSCC was observed in the cases for six genetic models including allele C vs. G (PA = 0.741), carrier C vs. G (PA = 0.853), homozygote CC vs. GG (PA = 0.085), heterozygote GC vs. GG (PA = 0.882), dominant GC + CC vs. GG (PA = 0.969), and recessive CC vs. GG + GC (PA = 0.980). Furthermore, no statistically significant difference between the cases and controls was detected in most subgroup meta-analyses (PA > 0.05). For the risk of OL, we did not observe the difference between the cases and controls for most genetic models in the overall meta-analysis and subsequent subgroup analysis (PA > 0.05). Begg’s test and Egger’s test excluded the large risk of publication bias within the included studies in the meta-analysis of OSCC. The sensitivity analysis indicated the above relatively stable results.ConclusionsOur updated meta-analysis (based on the current evidence) shows that TP53 rs1042522 may not confer susceptibility to OSCC. In addition, for the first time, we provided evidence regarding the negative association between TP53 rs1042522 and OL risk.Electronic supplementary materialThe online version of this article (10.1186/s12903-018-0603-6) contains supplementary material, which is available to authorized users.

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“…Se conoce que el cáncer se desarrolla a partir de la acumulación y selección sucesiva de alteraciones genéticas y epigenéticas, que permiten a las células sobrevivir, replicarse y evadir mecanismos reguladores de apoptosis, proliferación y del ciclo celular; también los mecanismos responsables de mantener y reparar el DNA se encuentran modificados 19 . El cáncer es una enfermedad de etiología multifactorial que en el 80 % de los casos se debe a factores exógenos o externos como, entre otros, los contaminantes ambientales, el estilo de vida el consumo de alcohol en exceso y el hábito de fumar, y en un 20% a factores endógenos, genéticos y epigenéticos 14 .…”

Section: Discussionunclassified

“…Las lesiones de los pacientes se agruparon en: lesiones benignas (LB), desórdenes orales potencialmente malignos (DOPM) y cáncer oral (CO); las mismas habían sido confirmadas por diagnóstico histopatológico. Los DOPM fueron diagnosticados como leucoplasias y líquenes orales (WHO classification ICD-10 K00-K14, 2010) 14 Se elaboraron mapas de tipo planar con el programa ArcGis 10.1, Esri. Las capas geográficas que se utilizaron fueron son: "manzanas.shp" e "industrias.shp" de la Ciudad de Córdoba (2012) brindadas por el OUC.…”

Section: Métodosunclassified

Geolocalización de pacientes con cáncer bucal en la ciudad de Córdoba: factores de riesgo ambientales

Nieto

2018

RevFacOdont

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Pollution comes from activities that man performs at all levels. Many of the polluting substances do not have immediate action on health and cause long-term chronic diseases such as cancer. An important contribution in oral cancer research is to study the relationships between space and community health. The Geographic Information Systems constitute a computer set (software and hardware) that allows analyzing geographic and spatial data such as events, people and environmental characteristics. The objective of the study was to determine the spatial distribution of patients with oral cancer and other oral lesions, using Geographic Information Systems and establish possible association with the presence of different types of industries in the City of Córdoba. Methods:Retrospective study of clinical histories of patients of both sexes (n = 476), who attended the External Clinic of the Chair of Stomatology "A" of the Faculty of Dentistry (UNC), period 2008 -2014. The lesions were grouped into: benign, potentially malignant oral disorders (leucoplasias and oral lichens) and oral cancer. The patients were geolocated, by spatial localization of geographic coordinates, according to the address declared in the Clinical History. The industries were classified as Harmful and Dangerous. Planar type maps were elaborated with the program ArcGis 10.1, Esri. The statistics were performed using absolute and relative frequencies. The association between industrial zones and the presence of lesions was evaluated through Correspondence Analysis. Results: There was an association between the presence of non-malignant lesions with dangerous industries and malignant lesions with harmful industries. Areas with dangerous and harmful industries were associated with the presence of potentially malignant disorders. Discussion: Our results allowed us to determine environmental risk patterns in the city of Córdoba, which could be applied to analyze and / or solve different aspects of public health in relation to oral cancer.

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Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

Cited by 14 publications

References 25 publications

Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer

Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer

Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis

Geolocalización de pacientes con cáncer bucal en la ciudad de Córdoba: factores de riesgo ambientales

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