El Repositorio Digital de la Universidad Nacional de Córdoba (RDU), es un espacio donde se almacena, organiza, preserva, prov ee acceso libre y procura dar visibilidad a nivel nacional e internacional, a la producción científica, académica y cultural en formato digital , generada por los integrantes de la comunidad universitaria. RISK GENES IN HEAD AND NECK CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF LAST 5 YEARSBrunotto Cita del documento:Brunotto, M, Zarate, A.M, Bono, A, Barra, J.L, Berra, S. Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years. Oral Oncol. 2014;3(50): 178-188. Disponible en: https://rdu.unc.edu.ar/handle/11086/5502Este documento está disponible para su consulta y descarga en RDU (Repositorio Digital de la Universidad Nacional de Córdoba) . El mismo almacena, organiza, preserva, provee acceso libre y da visibilidad a nivel nacional e internacional a la producción científica, académica y cultural en formato digital, generada por los miembros de la Universidad Nacional de Córdoba. Para más información, visite el sitio https://rdu.unc.edu.ar/ Esta iniciativa está a cargo de la OCA (Oficina de Conocimiento Abierto), conjuntamente con la colaboración de la Prosecretaria de Informática de la Universidad Nacional de Córdoba y los Nodos OCA. Para más información, visite el sitio http://oca.unc.edu.ar/ It is known that the apoptotic and proliferation genes are involved in cancer development and these could be useful as a biomarker of this pathology. Systematic reviews and meta-analysis allow stronger and more generalized conclusions for identifying some models of risk markers. These models may help in screening, early diagnosis and/or therapy in the clinic. 2-5In recent decades, there has been increased interest in genetic predisposition studies in complex disease. This has led to the production of an enormous number of epidemiologic papers about the relationship between genetic polymorphism and disease. However, the magnitude of association between specific polymorphism and disease is still not established. The aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates. METHODS Search strategy and selection criteriaThis study was made according to the PRISMA reporting items for systematic reviews and metaanalysis guidelines. We conducted a systematic review and meta-analysis of case-control studies from the MEDLINE, Scopus, Cochrane, and CancerLit databases between January 2007 and January 2013. Language is not restricted. The search strategy included the following keywords 3 (variably combined): "oral cancer", "oral cancer polymorphism", "oncogene", "tumor suppressor gene", "squamous cell carcinoma", "head and neck cancer". Data extractionData was collected of adult patients of both genders, with diagnosis of head and neck carcinoma according to the criteria of ICD-10C00-C14 WHO or another specific source, in whom genetic polymorphisms ...

Continuing with a program to develop new quinone derivatives as biologically active compounds, we designed and synthesized a new series of aryloxy‐quinones, which were evaluated in vitro against Trypanosoma cruzi in epimastigote form. Chemical modifications in three specific moieties on the aryloxy‐quinone core were considered for developing new anti‐T. cruzi agents. The majority of our new quinones showed higher potency (IC50 values of <0.70 µM) than nifurtimox, a known pharmaceutical used as a baseline drug (IC50 values of 7.00 µM); however, only two of them elicited higher selectivity than nifurtimox against Vero cells. A structure–activity relationship analysis provided information about the stereoelectronic features of these compounds, which are responsible for an increase in trypanosomicidal activity. Using a pharmacophore model, we mapped the substitution patterns of the five pharmacophoric features of trypanosomicidal activity. We chose the Epc1 compounds and found no relationship with the trypanosomicidal effects. These results provided useful information about the structural characteristics for developing new aryloxy‐quinones with higher potency against the protozoan parasite T. cruzi.

We designed, synthesized, and evaluated novel 2,6,9-trisubstituted purine derivatives for their prospective role as antitumor compounds. Using simple and efficient methodologies, 31 compounds were obtained. We tested these compounds in vitro to draw conclusions about their cell toxicity on seven cancer cells lines and one non-neoplastic cell line. Structural requirements for antitumor activity on two different cancer cell lines were analyzed with SAR and 3D-QSAR. The 3D-QSAR models showed that steric properties could better explain the cytotoxicity of compounds than electronic properties (70% and 30% of contribution, respectively). From this analysis, we concluded that an arylpiperazinyl system connected at position 6 of the purine ring is beneficial for cytotoxic activity, while the use of bulky systems at position C-2 of the purine is not favorable. Compound 7h was found to be an effective potential agent when compared with a currently marketed drug, cisplatin, in four out of the seven cancer cell lines tested. Compound 7h showed the highest potency, unprecedented selectivity, and complied with all the Lipinski rules. Finally, it was demonstrated that 7h induced apoptosis and caused cell cycle arrest at the S-phase on HL-60 cells. Our study suggests that substitution in the purine core by arylpiperidine moiety is essential to obtain derivatives with potential anticancer activity.

The laparoscopic access is a safe technique with satisfactory functional results after medium-term follow-up.

Combined therapy with adipose-mesenchymal stem cells, platelet-rich plasma and endorectal advancement flaps yielded good results in patients with refractory Perineal Crohn's Disease. This article is protected by copyright. All rights reserved.

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The crude mortality rate from CRC has doubled in Chile in this period. After adjustment of mortality rates, it appears that much of this increase is due to the aging population. However, part of this increase could be explained by other factors.