Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer

Abstract

Objectives: TP53 is an important tumor suppressor gene to maintain genomic integrity, and its mutations increase the susceptibility to oral carcinoma. Previous published studies have reported the relation of TP53 codon 72 polymorphism with the risk of oral carcinoma, but the results remain controversial and inconclusive.Methods: We therefore utilized meta-analysis based on a comprehensive search in PubMed, EMBASE, and Google of Scholar databases up to August 19, 2017.Results: Total 3,525 cases and 3,712 controls from 21 case-control studies were selected. We found no significant association between TP53 codon 72 polymorphism and oral carcinoma susceptibility in all genetic contrast models, including subgroup analysis based on control source and ethnicity. Furthermore, TP53 codon 72 polymorphism was not significant associated with oral carcinoma susceptibility in tobacco or alcohol use, and HPV infection status. Our results were confirmed by sensitivity analysis and no publication bias was found.Conclusions: Taken together, our data indicate that TP53 codon 72 polymorphism is not associated with the susceptibility to oral carcinoma.

Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders

“…In an updated meta-analysis, Sun et al [ 12 ] conducted an updated meta-analysis of 17 case–control studies from 16 articles with 3047 cases of OSCC and 3305 health controls, and concluded that there was no significant association between TP53 codon 72 polymorphism and the risk of OSCC in either the Asian or Caucasian population. This data was in agreement with the result from another contemporaneous meta-analysis [ 28 ]. Interestingly, Sun et al [ 12 ] performed an additional meta-analysis of 6 case–control studies from 5 articles with 391 cases of OLK and 763 health controls, and also found that no significant association of TP53 codon 72 polymorphism with OLK susceptibility.…”

Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews

“…After duplicate elimination, 3924 records were considered potentially eligible and screened according to titles and abstracts, leaving a sample of 92 studies for full text evaluation. Finally, 85 studies meeting all eligibility criteria were included for critical analysis and evidence synthesis in our scoping review [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , …”

“…To date, a significant number of systematic reviews and meta-analyses have been published on different implications of the TP53 gene and its product in carcinogenesis of the head and neck, particularly the oral cavity. Five meta-analyses have investigated the association between the rs1042522 polymorphism and susceptibility to the development of oral cancer [ 60 , 61 , 77 , 83 , 95 ]. The oncogenic mechanism linked to this polymorphism is due to the substitution of proline for arginine at codon 72, located in exon 4 of the TP53 gene.…”

Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors

“…The mutation in the TP53 gene is the most common alteration found in the carcinogenesis of HNSCC in humans. In human medicine, many studies relate the expression of this protein (assessed by IHC) and exposure to risk factors such as tobacco consumption [ 52 , 53 ]. Out of the studies investigating the exposure to ETS in cats with oral SCC, only two analyzed the expression of p53 in oral tissue and its association with exposure to ETS [ 12 , 13 ].…”