Study of The Protective Effect of Vitamin C plus E on Lincomycin-Induced Hepatotoxicity and Nephrotoxicity

Jwad, Saher Mahmood; Abbas, Bushra; Jaffat, Haider Salih

doi:10.5958/0974-360x.2015.00032.3

Cited by 6 publications

(3 citation statements)

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“…According to Jwad et al (2015), lincomycin may have harmful effects on hematology and serum biochemical variables, and may interfere with liver and kidney functions. In the study, there was a transient increase in triglycerides and cholesterol at dose of 40mg, possibly due to impaired liver function, and their values returned to normal levels within reference intervals previously recorded for tilapia under normal health conditions (MAUEL et al, 2007;HRUBEC et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The creatinine level is an indicator of renal function, therefore, the significant increase in its serum content after lincomycin administration can be attributed to the temporary impairment of the renal functional capacity, which can cause oxidative damage in the renal tubules, or probably due to the effect of this chemical antibiotic on the creatinine production rate, which leads to increase its biosynthesis (JWAD et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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CLINICAL SAFETY OF ORAL LICOMYCIN TREATMENT IN NILE TILAPIA (Oreochromis niloticus)

COSTA¹,

OLIVEIRA²,

ARACATI³

et al. 2022

Ars Vet

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Lincomycin is a broad-spectrum antimicrobial acting against Gram-positive bacteria, widely used in veterinary medicine. In fish, there are only limited in vitro data, thus requiring the design of effective therapeutic protocols for their use in aquatic organisms. In this context, the objective was to evaluate the clinical safety of lincomycin treatment, administered orally in tilapia, through hematological, biochemical and somatic index evaluation. A total of 136 tilapia (±100g) were randomly distributed in 17 tanks (100L of water, n=8) to constitute the following treatments: T0 (control group, not treated with lincomycin); T1, T2, T3 (treated with 10, 20 and 40mg/kg -1 of lincomycin b.w., respectively) and T4 physiological standard (reference values). Eight animals were sampled per treatment in 4 periods: 2, 4 and 8 days post-treatment (DPT), and a group that was treated for 8 days with the drug and then treated only with commercial feed until the 12th day (recovery period). Tilapia treated with lincomycin had no difference in the hematological and leukocyte evaluation, in the hepatic, renal and splenic somatic index. However, they presented a transient increase in the values of ALT, AST, cholesterol, triglycerides and creatinine, which returned to normal levels after the period of recovery (12DPT). Furthermore, an increase in total protein, albumin and globulin levels was observed in treated animals. It is concluded that although there were some transient changes during the experiment, lincomycin has a good clinical safety margin at doses of 10, 20 and 40mg/Kg -1 b.w. for Nile tilapia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CLINICAL SAFETY OF ORAL LICOMYCIN TREATMENT IN NILE TILAPIA (Oreochromis niloticus)

COSTA¹,

OLIVEIRA²,

ARACATI³

et al. 2022

Ars Vet

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“…It is persistent in the environment due to its pyranose ring, amide, pyrrolidine ring and other structures [10], and exhibits inhibitory effects and toxicity in organisms [11]. Lincomycin has numerous detrimental effects on the haematological and biochemical properties of blood, and can interfere with liver and kidney functions [12]. The EC 50 value of lincomycin for Artemia (brine shrimp) was 283.1 mg/L [13], and the IC 50 values of lincomycin for Cylindrotheca closterium and Navicula ramosissima were 14.16 mg/L and 11.08 mg/L, respectively [14].…”

Section: Introductionmentioning

confidence: 99%

Soil Behaviour of the Veterinary Drugs Lincomycin, Monensin, and Roxarsone and Their Toxicity on Environmental Organisms

Wang

et al. 2019

Molecules

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Lincomycin, monensin, and roxarsone are commonly used veterinary drugs. This study investigated their behaviours in different soils and their toxic effects on environmental organisms. Sorption and mobility analyses were performed to detect the migration capacity of drugs in soils. Toxic effects were evaluated by inhibition or acute toxicity tests on six organism species: algae, plants, daphnia, fish, earthworms and quails. The log Kd values (Freundlich model) of drugs were: lincomycin in laterite soil was 1.82; monensin in laterite soil was 2.76; and roxarsone in black soil was 1.29. The Rf value of lincomycin, roxarsone, monensin were 0.4995, 0.4493 and 0.8348 in laterite soil, and 0.5258, 0.5835 and 0.8033 in black soil, respectively. The EC50 for Scenedesmus obliquus, Arabidopsis thaliana, Daphnia magna and LC50/LD50 for Eisenia fetida, Danio rerio, and Coturnix coturnix were: 13.15 mg/L,32.18 mg/kg dry soil,292.6 mg/L,452.7 mg/L,5.74 g/kg dry soil and 103.9 mg/kg (roxarsone); 1.085 mg/L, <25 mg/kg dry soil, 21.1 mg/L, 4.76 mg/L, 0.346 g/kg dry soil and 672.8 mg/kg (monensin); 0.813 mg/L, 35.40 mg/kg dry soil, >400 mg/L, >2800 mg/L, >15 g/kg dry soil, >2000 mg/kg (lincomycin). These results showed that the environmental effects of veterinary drug residues should not be neglected, due to their mobility in environmental media and potential toxic effects on environmental organisms.

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Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish

Cheng

Fen

et al. 2020

Ecotoxicology and Environmental Safety

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Study of The Protective Effect of Vitamin C plus E on Lincomycin-Induced Hepatotoxicity and Nephrotoxicity

Cited by 6 publications

References 0 publications

CLINICAL SAFETY OF ORAL LICOMYCIN TREATMENT IN NILE TILAPIA (Oreochromis niloticus)

CLINICAL SAFETY OF ORAL LICOMYCIN TREATMENT IN NILE TILAPIA (Oreochromis niloticus)

Soil Behaviour of the Veterinary Drugs Lincomycin, Monensin, and Roxarsone and Their Toxicity on Environmental Organisms

Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish

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