Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish

Cheng, Bo; Fen, Jiang; Su, Meile; Zhou, Liqun; Zhang, Hua; Cao, Zigang; Liao, Xinjun; Xiong, Gaofeng; Xiao, Jianghong; Liu, Fasheng; Lu, Huiqiang

doi:10.1016/j.ecoenv.2020.110725

Cited by 35 publications

(11 citation statements)

References 34 publications

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“…In the early development of zebrafish, brain development, neuronal development, body length, and spontaneous tail coiling are important indicators of neurodevelopment. [38][39][40] In our study, we found blurred ventricular brain structures, eye malformations, shortened body lengths, reduced spontaneous tail coiling, and abnormal heart development. Spontaneous tail curling is the first spontaneous motor behaviour after fertilization in zebrafish.…”

Section: Discussionsupporting

confidence: 55%

Cinnamaldehyde causes developmental neurotoxicity in zebrafish via the oxidative stress pathway that is rescued by astaxanthin

et al. 2022

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Section: Discussionsupporting

confidence: 55%

Cinnamaldehyde causes developmental neurotoxicity in zebrafish via the oxidative stress pathway that is rescued by astaxanthin

et al. 2022

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“…Thus, it is urgent to better understand the complex consequences of commonly used antibiotic treatment. Lincomycin is commonly used to treat a variety of Gram-positive bacterial infections, including respiratory tract, skin, and soft tissue infections [9]. Due to its low price and no need for a skin test, lincomycin is widely used in clinical practice.…”

Section: Antibiotic Exposure Can Decrease Body Weight Gain Of Micementioning

confidence: 99%

Short-Term Lincomycin Exposure Depletion of Murine Microbiota Affects Short-Chain Fatty Acids and Intestinal Morphology and Immunity

et al. 2020

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Lincomycin, as one of the most commonly used antibiotics, may cause intestinal injury, enteritis and other side effects, but it remains unknown whether these effects are associated with microbial changes and the effects of different doses of lincomycin on infants. Here, 21-day old mice were exposed to 1 and 5 g/L lincomycin to explore the effects of lincomycin on the gut microbiota, metabolites and inflammation. Compared to the control mice, 1 g/L lincomycin exposure decreased the body weight gain of mice (p < 0.05). Both 1 and 5 g/L lincomycin exposure reduced the diversity and microbial composition of mice (p < 0.05). Furthermore, 1 and 5 g/L lincomycin reduced the relative concentrations of acetate, propionate, butyrate, valerate, isobutyric acid and isovaleric acid in the colon chyme of mice (p < 0.05). In addition, 5 g/L lincomycin exposure reduced the villus height, crypt depth, and relative expression of TLR2, TLR3, TLR4, IL-18, TNF-α, and p65 in the jejunum of mice (p < 0.05), while 1 g/L lincomycin exposure reduced the relative expression of TLR2, TLR3, TNF-α, and p65 (p < 0.05). Collectively, these results highlight the depletion effect of short-term lincomycin exposure on microbiota and the further regulatory effect on intestinal morphology and immunosuppression in infant mice.

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“…ACh was the first neurotransmitter identified whose accumulation causes disruption of cholinergic synapses and neuromuscular connections and leads to neurotoxicity (Tao et al, 2022).AChE regulates ACh levels by hydrolyzing ACh to choline and acetate to eliminate the excitatory effects of ACh accumulation on the postsynaptic membrane (Cheng et al, 2020). The present study found that BM-DBM induced a significant elevation in ACh content, whereas no elevation in AChE activity occurred to eliminate ACh.…”

Section: A B Figurementioning

confidence: 42%

Interactive neurotoxicity of environmentally relevant concentrations of polystyrene nanoplastics and butyl methoxydibenzoyl methane on early zebrafish embryos

et al. 2022

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Organic ultraviolet filters (OUVFs) and nanoplastics (NPs) are two important new pollutants that coexist widely in freshwater and coastal habitats. Both OUVFs and MPs can be taken up by aquatic organisms and may be toxic or co-toxic. In this study, the neurotoxicity and interaction neurotoxicity of the typical OUVFs butyl methoxydibenzoyl methane (BM-DBM) and polystyrene nanoplastics (PS-NPs) on zebrafish at environmental concentrations were comprehensively investigated at the tissue and molecular levels using transgenic or non-transgenic zebrafish. Results showed that both BM-DBM and PS-NPs induced abnormal expression of developmental genes neurogenin 1, glial fibrillary acidic protein, Finkel-Biskis-Jinkins osteosarcoma oncogene, growth-associated protein 43, synapsin IIa, and apoptosis regulator a (Bcl2a), Bcl2 associated x and apoptosis-related cysteine peptidase a, neuronal loss, motor neuron axon deletion, neuronal apoptosis and behavioral abnormalities in larvae thus being neurotoxic. BM-DBM also specifically interferes with neurotransmitter systems and affects signaling between neurons. In addition, PS-NPs and BM-BDM exerted synergistic and antagonistic effects in inducing apoptosis in neuronal cells and developmental neurotoxicity, respectively. Our results highlight the neurotoxic risk of PS-NPs and BM-BDM and the complex interactive neurotoxic effects of the two. We anticipate that our study may lay the foundation for ecological risk assessment of OUVFs and PS-NPs and exploration of complex interactions between PS-NPs and hydrophobic organic pollutants.

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Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish

Cited by 35 publications

References 34 publications

Cinnamaldehyde causes developmental neurotoxicity in zebrafish via the oxidative stress pathway that is rescued by astaxanthin

Cinnamaldehyde causes developmental neurotoxicity in zebrafish via the oxidative stress pathway that is rescued by astaxanthin

Short-Term Lincomycin Exposure Depletion of Murine Microbiota Affects Short-Chain Fatty Acids and Intestinal Morphology and Immunity

Interactive neurotoxicity of environmentally relevant concentrations of polystyrene nanoplastics and butyl methoxydibenzoyl methane on early zebrafish embryos

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