Study of the inhibition effect of ethanolic extract of mangosteen pericarp on atherogenesis in hypercholesterolemic rat

Wihastuti, Titin Andri; Widodo, M. Aris; Heriansyah, Teuku; Sari, Novita

doi:10.1016/s2222-1808(15)60940-9

Cited by 12 publications

(11 citation statements)

References 21 publications

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“…In the present study,lowest LDL levelwas obtained from treatment of MPEE at 9 weeks compared to control and orlistat. Mangosteen Pericarp Ethanolic Extracts (MPEE) has been previously reported in several studies to inhibit cholesterol formation process 19,29,30 .…”

Section: Discussionmentioning

confidence: 99%

Antihyperlidemic Effects of Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract In High-Carbohydrate Wistar Rats

Abuzaid¹,

Sukandar²,

Kurniati³

et al. 2017

Journal of Natural Remedies

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Section: Discussionmentioning

confidence: 99%

Antihyperlidemic Effects of Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract In High-Carbohydrate Wistar Rats

Abuzaid¹,

Sukandar²,

Kurniati³

et al. 2017

Journal of Natural Remedies

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“…The ethanolic extract of mangosteen pericarp (800 mg/kg) in hypercholestromic rat improved lipid profile, decreased level of H 2 O 2 and the expression of NF‐κB, iNOS, maintained the expression of eNOS and reduced HIF‐1α that lead to decrease vasa vasorum angiogenesis. The formation of vasa vasorum in an arterial vessel helps in progression of atherosclerosis plaque, so the ethanolic extract of mangosteen pericarp through its anti‐oxidant and antiinflammatory actions can prevent atherosclerosis (Tanaka et al, ; Wihastuti et al, ; Wihastuti et al, ). Diet supplemented 1% cholesterol in rat with 5% of mangosteen hindered rise in plasma lipid, total cholesterol liver and decrease in plasma anti‐oxidant activity (Haruenkit et al, ; Leontowicz et al, ).…”

Section: Methodsmentioning

confidence: 99%

Review ofGarcinia mangostanaand its Xanthones in Metabolic Syndrome and Related Complications

2017

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Metabolic syndrome is coexistence of abdominal obesity, hyperglycemia, hyperlipidemia and hypertension that causes cardiovascular diseases, diabetes and their complications, low quality and short lifespan. Garcinia mangostana and its xanthones such as α-mangostin have been shown desirable effects such as anti-obesity, anti-hyperglycemic, anti-dyslipidemia, anti-diabetic and antiinflammatory effects in experimental studies. Various databases such as PubMed, Scopus and Web of Science with keywords of 'Garcinia mangostana', 'mangosteen', 'α-mangostin', 'metabolic syndrome', 'hypoglycemic', 'antihyperglicemic', 'antidiabetic', 'hypotensive', 'antihypertensive', 'atherosclerosis', 'arteriosclerosis' and 'hyperlipidemia' have been investigated in this search without publication time limitation. This study reviewed all pharmacological effects and molecular pathways of G. mangostana and its xanthones in the management of metabolic syndrome and its complications in in-vitro and in-vivo studies. Based on these studies, mangosteen and its xanthones have good potential to design human studies for controlling and modification of metabolic syndrome and its related disorders such as obesity, disrupted lipid profile, diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.

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“…ICU is a unit in the hospital that provides special care to patients (Jang, Park, Kim, & Chang, 2018). Life-threatening conditions include trauma, heart disease, stroke and others (Burke et al, 2013;Wihastuti, Widodo, Heriansyah, & Sari, 2015). WHO states that of the 56.9 million people who died in 2016, stroke and ischemic heart disease were the highest causes of death in the world, which reaches nearly 15.2 million people (WHO, 2018).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Mindfulness Meditation on Mental Illness among Nurse in ICU and ICCU

Hatmalyakin¹,

Utami²,

Wihastuti³

2019

RJLS

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Critical conditions as one of the main focused in hospital care. This condition required rapid, comprehensive and quality management that carried out by nurses especially in the treatment of cardiovascular disease. This condition caused pressure on the nurse and causes stress. This stress can be overcome by complementary and alternative therapy in the form of mindfulness meditation. The purpose of this study was to identify the effect of mindfulness meditation therapy in reducing stress on nurses in ICU and ICCU. This study is quasy experiment research design through one group pretest posttest approach with respondents were 14. The results of this study indicated that there was decreased in stress before and after intervention with p-value=0000 and stress before and 1 week after intervention with p-value=0.001. Mindfulness therapy can reduce nurse stress.

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Study of the inhibition effect of ethanolic extract of mangosteen pericarp on atherogenesis in hypercholesterolemic rat

Cited by 12 publications

References 21 publications

Antihyperlidemic Effects of Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract In High-Carbohydrate Wistar Rats

Antihyperlidemic Effects of Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract In High-Carbohydrate Wistar Rats

Review ofGarcinia mangostanaand its Xanthones in Metabolic Syndrome and Related Complications

The Effect of Mindfulness Meditation on Mental Illness among Nurse in ICU and ICCU

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