Review ofGarcinia mangostanaand its Xanthones in Metabolic Syndrome and Related Complications

Abstract

Metabolic syndrome is coexistence of abdominal obesity, hyperglycemia, hyperlipidemia and hypertension that causes cardiovascular diseases, diabetes and their complications, low quality and short lifespan. Garcinia mangostana and its xanthones such as α-mangostin have been shown desirable effects such as anti-obesity, anti-hyperglycemic, anti-dyslipidemia, anti-diabetic and antiinflammatory effects in experimental studies. Various databases such as PubMed, Scopus and Web of Science with keywords of 'Garcinia mangostana', 'mangosteen', 'α-mangostin', 'metabolic syndrome', 'hypoglycemic', 'antihyperglicemic', 'antidiabetic', 'hypotensive', 'antihypertensive', 'atherosclerosis', 'arteriosclerosis' and 'hyperlipidemia' have been investigated in this search without publication time limitation. This study reviewed all pharmacological effects and molecular pathways of G. mangostana and its xanthones in the management of metabolic syndrome and its complications in in-vitro and in-vivo studies. Based on these studies, mangosteen and its xanthones have good potential to design human studies for controlling and modification of metabolic syndrome and its related disorders such as obesity, disrupted lipid profile, diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.

Berberine and barberry (Berberis vulgaris): A clinical review

“…Metabolic syndrome is characterized by a group of metabolic abnormalities including obesity, dyslipidemia, hypertension, and type 2 diabetes mellitus and is an important cardiovascular risk factor. In recent years, many studies have provided evidence for protective effects of various medicinal plants against metabolic syndrome, including grapes ( Vitis vinifera L.), red pepper ( Capsicum annuum L.), garcinia mangostana L., saffron ( Crocus sativus L.), cinnamon ( Cinnamomum verum L.), rosemary ( Rosmarinus officinalis L.), garlic ( Allium sativum L.), and black cumin ( Nigella sativa L.; Akaberi & Hosseinzadeh, ; Sanati, Razavi, & Hosseinzadeh, ; Tousian Shandiz, Razavi, & Hosseinzadeh, ; Razavi & Hosseinzadeh, ; Mollazadeh & Hosseinzadeh, ; Hassani, Shirani, & Hosseinzadeh, ; Hosseini & Hosseinzadeh, ; Razavi & Hosseinzadeh, ).…”

Synergetic therapy of glioma mediated by a dual delivery system loading α-mangostin and doxorubicin through cell cycle arrest and apoptotic pathways

“…Mangostins are tropical plants, of which xanthones are important secondary metabolites 18 . As an aprenylated xanthone derivative of mangosteen, α-mangostin (α-m) has been shown to possess a variety of pharmacological properties, including anti-inflammatory, neuroprotective and anticancer effects 19 – 23 . The antineoplastic effects of α-m were first observed against leukemia 24 .…”

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

“…So many plants and their constituents downregulate various adverse health problems related to metabolic disorders. In this case, berberine (Tabeshpour, Imenshahidi, & Hosseinzadeh, 2017), green tea (Razavi, Lookian, & Hosseinzadeh, 2017), avocado (Tabeshpour, Razavi, & Hosseinzadeh, 2017), cinnamon (Mollazadeh & Hosseinzadeh, 2016), saffron , rosemary (Hassani, Shirani, & Hosseinzadeh, 2016), garlic (Hosseini & Hosseinzadeh, 2015), Garcinia mangostana (Tousian, Razavi, & Hosseinzadeh, 2017), milk thistle (Tajmohammadi, Razavi, & Hosseinzadeh, 2018), and grape (Akaberi & Hosseinzadeh, 2016) may partly influence some compartments of metabolic syndrome.…”