Study of coat quality of tablets coated by an on-line supercell coater

Abstract

The aim of this study was to investigate the nature of Supercell coating, an on-line tablet coater that employed a unique pattern of airflow. Tablets coated at different spray rates (4, 6, 8, 10, and 12 mL/min) were analyzed to investigate the influence of different wetting conditions on the quality of coats formed. Scanning electron micrographs showed that tablet coats formed at a spray rate of 4 mL/min consisted of spray-dried droplets that did not coalesce. At a spray rate of 6 mL/min, surface roughness was found to be lower than at the other spray rates, and the coat appeared smoothest, whereby droplets seemed fused together. At higher spray rates, the droplets appeared as branching arms and scale-like structures. This was attributed to the spread of spray droplets by the processing air and mass transfer of wet coating materials between tablets. Further tests showed that coats formed at higher spray rates had higher drug yield, drug uniformity, color uniformity, and density. However, the variability in coat thickness was increased due to the mass transfer of coats and dissolution of tablet core surfaces by the coating material. Since coats of different characteristics can be formed in Supercell coating, the choice of wetting conditions would depend on the type of coat required and the coating materials used.

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

“…Cross-linked PVP also called crospovidone, is insoluble in water and highly compactable. Crospovidone is used as a super disintegrant in tablets and suppositories due to its high swelling properties, unlike soluble PVP [ 178 , 179 ]. Ludipress is a novel excipient which contains lactose (as filler/carrier), Kollidon K30 (binder, povidone) and Kollidon CL (super disintegrant, crospovidone) and hence, the manufacturer can simply mix the active ingredient with this Ludipress and lubricant, followed by direct compression which saves a lot of time and processing.…”

Phase behavior of ASDs based on hydroxypropyl cellulose

“…In this work, we investigate the stabilization potential of HPC for application in ASDs. HPC is a modified cellulose already applied for several tablet-coating applications or as tablet binder ( Picker-Freyer and Dürig, 2007 ) and recently also discussed as excipient for ASD applications ( Sarode et al, 2014a ; Osawa et al, 2014 ). It is soluble in many organic solvents and in water and thus applicable in spray-drying manufacturing processes.…”

Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease

“…It is thought that the main reason for this is that, unlike the F-5 formulation, sodium starch glycolate (Na-starch glycolate) and cross-PVP were added to the F-9 formulation, and cross-PVP was added to the F-12 formulation. Because these excipients are superdisintegrants [10]. Cross-PVP can swell without gelling.…”