Study of cervical cytology and its correlation with clinical and histopathological findings

Bamanikar, Sunita; Baravkar, Dadaso; Chandanwale, Shirish S; Dharwadkar, Arpana; Paranjape, Sourabh

doi:10.4103/2278-0513.197869

Cited by 12 publications

(29 citation statements)

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“…[1] In the present study, the mean age of cases of malignant cervical lesions was 53.9 years (SD±11.28) while for premalignant lesions was 40 years (SD±10.83). This study is in concordance with a previous study from India which has observed the mean age of incidence of cervical pre malignant and malignant lesions to be 39 years and 49 years with an age range of 31-40 years and 41-60 years respectively [7].…”

Section: Discussionsupporting

confidence: 92%

Expression of Ki 67 and human papilloma virus 16 with risk factors in cervical pre malignant and malignant lesions

Agarwal

Chandra

Barua

et al. 2019

Trop J Pathol Microbiol

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Introduction: The present study was conducted to assess immunohistochemical expression of Ki-67 and HPV 16 in premalignant and malignant lesions of cervix. It was also intended to study the risk factors which may be associated with these lesions in Uttarakhand state of India. Material and Method: The study including premalignant and malignant lesions of cervix diagnosed over period of one year. Immunohistochemical staining on paraffin blocks for all cases and controls were done for HPV 16 and Ki-67. Ki-67 score was quantified depending on the percentage of positive cells and was statistically analyzed in association with HPV expression. Results: The study included 50 cases of premalignant and malignant cervical lesions and 50 controls. 87.2% of the HPV 16 positive cases were also positive for Ki-67 expression which was statistically significantly higher in comparison to controls. Ki-67 expression was negative in all the controls while 90% of cases showed positivity for Ki-67. The malignant lesions of cervix show a significantly higher grade of Ki-67 expression in comparison to premalignant lesions (p value< 0.001). Conclusion: Low socioeconomic and education status, smoking (either active or passive), early age of sexual contact and first conception with high parity were associated with increased risk of cervical premalignant and malignant lesions in this region of India. Ki-67 plays an important role in carcinogenesis of cervical cancer in association of HPV16. The increase of immunopositivity of Ki-67 with the severity of lesions suggests its use in stratification of premalignant and malignant lesions of cervix.

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Section: Discussionsupporting

confidence: 92%

Expression of Ki 67 and human papilloma virus 16 with risk factors in cervical pre malignant and malignant lesions

Agarwal

Chandra

Barua

et al. 2019

Trop J Pathol Microbiol

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“…In this category, the smears included were those who were scanty in cell population according to Bethesda system 2014, smears obscured by in lammatory exudates, blood or mucin >75% area. Our result was comparable to result by (Bamanikar et al, 2016) and (Sachan et al, 2018) who reported the inadequacy rate as 5.99% and 6.42% respec- 4641(95.35) 4 (30.77) 1 (10) 0 (0) 0 (0) 0.00 ASC-US 61 (2.33) 3 (23.07) 2 (20) 0 (0) 0 (0) ASC-H (5) 0 (0) 1 (7.7) 1 (10) 2 (33.33) 1 (5) LSIL 81 (2.33) 4(30.77) 2 (20) 1 (16.67) 0 (0) HSIL (10) 0 (0) 1 (7.7) 4 (40) 3 (50) 2 (10) IC 170 (0) 0 (0) 0 (0) 0 (0) 17 (85) Total (92) 43 13 10 6 20 tively. In contrast, the inadequacy rate by (Kothari et al, 2014) was low-1.09% and that by (Warpe et al, 2016) was little higher than us -7.43%.…”

Section: Discussionsupporting

confidence: 91%

A Clinicopathological study of uterine cervical lesions in a Tertiary Care Centre

Kumbhar

Kanetkar

Mane

et al. 2020

ijrps

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Pap test is a simple yet effective screening method to detect cervical cancer in its early stage, and thus it helps to reduce morbidity and mortality from cancer. A total of 430 cases were studied after taking ethical clearance. The cytological diagnoses were made by Cytopathologist using Bethesda 2014 system for categorization of cervical smears. Cytological results were correlated with clinical features and histopathological results wherever biopsy was available. The total of the 430 cases studied 24 (5.58%) were inadequate to report, excluding these, of the total 406 cases 260 (64.04%) cases were symptomatic, and 146 (35.96%) were asymptomatic. Cytologic diagnoses were NILM –normal- 140 (55.23%)with a mean age of 38.48 years, NILM- inflammatory 128 (47.76%) with a mean age of 35.96 years, ASC-US 36 (8.86%) with a mean age of 36.69 years, ASC-H 18 (4.43%) with a mean age of 45 years, LSIL 42 (10.34%) with a mean age of 41.90, HSIL 22 (5.42%) with a mean age of 51.22 years, and invasive cancer 20 (4.92%) with a mean age of 61.8 years. Sensitivity, specificity, and positive predictive value, negative predictive value and accuracy of Pap test were 89.79%, 95.34%, and 95.65%, 89.13% and 83.33% respectively. Pap smear test is a simple, rapid, economical, still practical screening test to detect cervical intraepithelial lesions and cancer.

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“…This was in accordance with other studies in literature. 18,19 Bamanikar et al 20 observed that among 3337 cases reported as NILM, 2111 cases were found normal. Among infectious category, nonspecific inflammation was most common finding (877 cases, 26.28% of all NILM cases).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Cervical Cytology Using PAP Smear in Women Residing in Bangalore Rural, India

Vedavathi¹,

Anusuya²,

Parimala³

et al. 2019

jebmh

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BACKGROUND Cervical cancer is one of the most deadly and common forms of cancer among women, worldwide. This disease could is preventable, by detecting it using Pap screening test. The objective of this study was to determine the pattern of various cervical smear abnormalities and to study the prevalence of epithelial cell abnormalities in our study population. METHODS A total of 200 married women between 21-70 years of age were enrolled in the study. Pap smear was done by the conventional method and reporting was done based on the Bethesda system 2014. Emphasis was put on epithelial cell abnormalities and the findings of abnormal epithelial lesions were correlated with histopathology. RESULTS Vaginal discharge was the most common complaint, occurring in 38% of the women. Lower abdominal pain was the complaint of 14% patients and irregular menstrual cycle of 13% of women, while 20% were asymptomatic. 41% had inflammatory changes. Atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), and high-grade squamous intraepithelial lesion (HSIL) were detected in 4%, 3.5%, and 1%, respectively. CONCLUSIONS Pap smear is a cost-effective simple test mainly to detect precancerous lesions of cervix which can be treated and followed up to down stage the disease.

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Study of cervical cytology and its correlation with clinical and histopathological findings

Cited by 12 publications

References 0 publications

Expression of Ki 67 and human papilloma virus 16 with risk factors in cervical pre malignant and malignant lesions

Expression of Ki 67 and human papilloma virus 16 with risk factors in cervical pre malignant and malignant lesions

A Clinicopathological study of uterine cervical lesions in a Tertiary Care Centre

Analysis of Cervical Cytology Using PAP Smear in Women Residing in Bangalore Rural, India

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