Cystic hygroma (CH) is a benign infiltrative malformation of the lymphatic channels. We report a case of a 28-year-old Indian female who presented with rapidly enlarging right sided neck swelling over the posterior triangle since 5 days. Complete resection of CH is sometimes not amenable because of its infiltrative nature and involvement of surrounding vital structures. However, in our patient successful complete surgical resection was undertaken. The MRI findings of our patient were consistent with brachial cleft cyst; this posed a challenge in the diagnosis of CH. The histopathological analysis of the resected mass confirmed CH. CH is rare in adults and such an acute presentation is exceptionally atypical. History of prior trauma and infection are known etiological factors for adult CH; these were conspicuously absent in our patient. CH should be considered in the differentials of rapidly enlarging cystic swelling of posterior region of neck in adults. Optimal and timely management is necessary to achieve a favorable prognosis. Therefore, we report a case of rapidly enlarging cervical CH in an adult along with extensive literature review to have a better understanding regarding epidemiology, etiopathogenesis, clinical presentation, optimal management, and prognosis of such a rare entity in adults.

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A 45-year-old female complained of a painless swelling, which had developed in the epigastric region, and was slowly growing in size over the last one year. The patient had undergone excision of a similar swelling at the same site seven years ago and was now facing recurrence. Histopathology and immunohistochemical (IHC) examination confirmed the diagnosis of Dermatofibrosarcoma Protuberans.

BACKGROUND Uterine cervix acts as a "gateway" for various infections, which affects cervix, uterus and upper genital tract, thus working under various pathological conditions leading to various lesions of cervix as well as acting as a sentinel for upper genital tract infections. Cervical specimens like biopsies and sections of cervix from hysterectomy specimens form a significant part of surgical specimens in any histopathology laboratory. Among all cervical lesions, cervical inflammatory lesions are the most common cervical lesions on histopathology followed by malignant lesions. The aim and objective of the present study was conducted to study and classify various cervical lesions on histopathology and to correlate histopathological findings with the clinical presentation of patients. MATERIALS AND METHODS A total of 788 cervical specimens were studied in this prospective study carried out over a period of two years from June 2013 to May 2015 in Department of Pathology of a tertiary care hospital. All the detailed demographic data, age, clinical presentation were noted and histopathological examination and diagnosis of cervical specimens was done. RESULTS During this prospective study done over a period of two years from June 2013 to May 2015. A total of 788 cervical specimens that included cervical biopsies and sections of cervix from hysterectomy specimens were studied. CONCLUSION A variety of cervical lesions were observed in total 788 specimens sent for histopathological examination. Inflammatory lesions were the most common cervical lesions followed by malignancies, benign lesions, precursor lesions and cervical glandular lesions. Every cervical specimen sent for histopathological examination should be studied meticulously as the diagnosis bears implications on treatment and prognosis.

Objectives: Oral Submucous Fibrosis (OSMF) is potentially malignant disorder known to transform into oral cancer. The aim of this study is to determine the degree and pattern of expression of aberrant Ki67 in OSMF, oral squamous cell carcinoma (OSCC) and in normal oral mucosa patients (NOM). The objective is to correlate between Ki67 expression and degree of dysplasia in OSMF patents and also Ki67 expression with clinical and histological grading of OSMF and OSCC patient. Materials and Methods: A prospective cross-sectional study was conducted with purposive sampling technique from Jan 2017 to April 2020.The study groups consist of 35 OSMF cases, 10 cases of each OSCC and NOM. The samples were immunohistochemically analyzed for expression Ki67 antigen using chi-square test (P < 0.05). Results: The expression of Ki67 was significantly higher in OSMF than that of NOM samples, but less than that of OSCC samples. Present study showed correlation between expression of Ki67 with clinical staging and histological grading both in OSMF and OSCC patients. Conclusion: The study demonstrated a high incidence of Ki67 over expression in, OSMF and OSCC. Hence, Ki-67 can be widely used as a proliferation marker to measure growth fraction of cells in OSMF and also for determining the severity of epithelial dysplasia.