Studies on Resistance in Snails. 4. Induction of Ventricular Capsules and Changes in the Amebocyte-Producing Organ during Sensitization of Biomphalaria glabrata Snails

Lie, Kian Joe; Heyneman, Donald; Jeong, K.H.

doi:10.2307/3279288

Cited by 27 publications

(11 citation statements)

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“…The APW is a flat, roughly triangular sheet of tissue located ventral to the saccular kidney at the rear of the mantle cavity [37], and is covered posteriorly by simple squamous pericardial epithelium and anteriorly by simple cuboidal mantle epithelium [38]. Between the mantle and pericardium of the APW lie loose connective tissue and a haemolymph sinus.…”

Section: Gastropod Haematopoiesis and Haemocyte Functionmentioning

confidence: 99%

Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves

Pila

Sullivan

et al. 2016

Developmental & Comparative Immunology

111

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Haematopoiesis is a process that is responsible for generating sufficient numbers of blood cells in the circulation and in tissues. It is central to maintenance of homeostasis within an animal, and is critical for defense against infection. While haematopoiesis is common to all animals possessing a circulatory system, the specific mechanisms and ultimate products of haematopoietic events vary greatly. Our understanding of this process in non-vertebrate organisms is primarily derived from those species that serve as developmental and immunological models, with sparse investigations having been carried out in other organisms spanning the metazoa. As research into the regulation of immune and blood cell development advances, we have begun to gain insight into haematopoietic events in a wider array of animals, including the molluscs. What began in the early 1900’s as observational studies on the morphological characteristics of circulating immune cells has now advanced to mechanistic investigations of the cytokines, growth factors, receptors, signalling pathways, and patterns of gene expression that regulate molluscan haemocyte development. Emerging is a picture of an incredible diversity of developmental processes and outcomes that parallels the biological diversity observed within the different classes of the phylum Mollusca. However, our understanding of haematopoiesis in molluscs stems primarily from the three most-studied classes, the Gastropoda, Cephalopoda and Bivalvia. While these represent perhaps the molluscs of greatest economic and medical importance, the fact that our information is limited to only 3 of the 9 extant classes in the phylum highlights the need for further investigation in this area. In this review, we summarize the existing literature that defines haematopoiesis and its products in gastropods, cephalopods and bivalves.

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Section: Gastropod Haematopoiesis and Haemocyte Functionmentioning

confidence: 99%

Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves

Pila

Sullivan

et al. 2016

Developmental & Comparative Immunology

111

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“…One view postulates the presence of a specific organ, the amebocyte producing organ or APO, from where all the defense cells would take origin (Sminia et al 1974, Lie et al 1976, Sullivan 1990. One main argument in favor of this theory derives from the observation of an increased number of cells in mitosis within the APO when the snails become infected with S. mansoni (Sullivan 1990).…”

mentioning

confidence: 99%

Ki-67 is expressed in multiplying forms of Schistosoma mansoni, but not in snail host tissues

Silva

Souza

Almeida

et al. 2007

Mem. Inst. Oswaldo Cruz

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Ki-67 is a protein expressed in the nucleus of several species during cell-division, being absent during the GO resting phase of the cellular cycle. During attempts to disclose mitosis in the so-called "amebocyte-producing organ" in Biomphalaria glabrata infected with Schistosoma mansoni, the parasite multiplying forms appeared strongly marked for Ki-67, while the snail tissues were completely negative. These data are worth registering to complement general data on Ki-67, and to help future studies on the relationship of the parasite and of its intermediate host.

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“…The resistance of Biomphalaria snails to parasitic infection with Schistosoma mansoni is directly related to the hemocyte capacity of the vector to phagocytose and destroy 1,2,3,4 newly penetrated parasites . The hemocytes are the mollusk's main line of defense against parasites and http://revista.iec.pa.gov.br…”

Section: Introductionmentioning

confidence: 99%

Hemocyte production in Biomphalaria glabrata snails after exposure to different Schistosoma mansoni infection protocols

Santos¹,

Santos²,

Rodrigues³

2011

Rev Pan-Amaz Saude

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The objective of this work was to determine the profile of the cellular defense system during mansonic infection. Specifically, this study assessed the number of hemocytes that were produced and released into the hemolymph in response to the parasitic infection. The quantification of the Biomphalaria glabrata hemocytes was performed on groups of snails at 1, 5, 10, 15, 20 and 30 days post-infection that had been individually infected with 5, 10, 15 or 30 Schistosoma mansoni miracidia. The results revealed that B. glabrata possesses a cellular defense mechanism that is characterized by the release of hemocytes into the hemolymph. The maximum peak of cellular production occurred 24 hours after infection, and there was a significant reduction in the hemocyte concentration over the following 10 days. However, at 15 days post-infection, there was a second increase in the cellular hemocyte production, although this was not as strong as the primary peak. At 30 days post-infection, there was another moderate rise in the cellular hemocyte production. Based on this cellular response profile, the defense system of the snail appears to be effective immediately following infection, but the response does not ensure the destruction of all parasites during the course of the infection.

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Studies on Resistance in Snails. 4. Induction of Ventricular Capsules and Changes in the Amebocyte-Producing Organ during Sensitization of Biomphalaria glabrata Snails

Cited by 27 publications

References 0 publications

Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves

Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves

Ki-67 is expressed in multiplying forms of Schistosoma mansoni, but not in snail host tissues

Hemocyte production in Biomphalaria glabrata snails after exposure to different Schistosoma mansoni infection protocols

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