Studies on Chronic Vitamin B6 Deficiency in the Rat II. Changes in Tissue Metabolism

Olsen, Norman S.; Martindale, William E.

doi:10.1093/jn/53.3.329

Cited by 14 publications

(5 citation statements)

References 11 publications

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“…In almost all cases, there was an increase in relative organ weight probably due to lowered terminal body weight. An increase in weight of vital organs has been reported in vitamin B 6 -deficient rats (Olsen and Martindale, 1954;Seronde, 1960).…”

Section: Resultsmentioning

confidence: 98%

Detoxification of Commercial Linseed Meal for Use in Broiler Rations

et al. 1986

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A method for the detoxification of commercial deoiled linseed meal was standardized that involved water boiling of powdered meal and subsequent removal of water solubles by centrifugation. The hot-air dried sludge was evaluated for its possible use as a protein supplement in broiler chick rations. Growth studies of chicks showed that water-boiled linseed meal at 50% protein replacement level was superior to, and at 75% protein replacement level was on par with, the control diet based on expeller pressed groundnut cake. Raw linseed meal at 20% protein replacement level was significantly inferior. Chicks fed on processed linseed meal showed no gross histopathological and biochemical changes. Increased weight of the heart, lungs, pancreas, liver, kidney, brain and adrenals, higher serum globulin content, and a marked accumulation of cystathione in kidney, liver, and brain were observed in chicks fed raw linseed meal.(Key words.-linseed meal, detoxification, free amino acids, broiler rations) 1986 Poultry Science 65:164-171

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Section: Resultsmentioning

confidence: 98%

Detoxification of Commercial Linseed Meal for Use in Broiler Rations

et al. 1986

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“…The liver weight was found to have increased (Olsen & Martindale, 1954), but no alteration in the level of protein in liver (Beare, Beaton, Smith, White & McHenry, 1953) or carcass (Beare, Beaton & McHenry, 1953) has been noted. Other investigators (Ross & Pike, 1956), however, have observed a higher nitrogen content of liver; since the liver was enlarged, there was also a much higher level per unit body-weight.…”

Section: Discussionmentioning

confidence: 93%

Body composition of rats in B-vitamin deficiencies

Guggenheim

Diamant

1959

Br J Nutr

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“…It is apparent that increased skeletal growth previously reported in the handled normal young rat (6), is abolished by hypophysectomy. This suggests that the effect of handling on skeletal growth requires pituitary hormones, presumably growth hormone and/or thyrotropic hormone.…”

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confidence: 66%

“…In the normal rat, handling has no influence on amount of food ingested ( 6). When weight gains are corrected for amount of food ingested, increases in weight of the handled over unhandled group are greatly magnified.…”

mentioning

confidence: 97%

“…P W o l o g y , Pathology, edited by Sebrell, Jr., W. H., and Harris, R. S., Academic Press, N. Y., 1954, v3, 239. nutritional state of the animals in regard to Lysine deficiency has been produced experimentally in rats and swine by feeding diets deficient in lysine(l), by feeding diets containing "deaminized casein'' as a source of protein(2,3), and by feeding diets low in lysine to which hexahomoserine ( 6-hydroxy-DLnorleucine) , a lysine antagonist, was added (4)(5)(6)(7). Pyridoxal phosphate levels were determined in the heart, liver, kidney, muscle, circulating leukocytes, plasma and whole blood of rats on a synthetic diet with and without added Vit.…”

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confidence: 99%

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Pyridoxal Phosphate (B6-al-PO4) Levels in Organs, Leukocytes and Blood of Rats with Developing Vit. B6 Deficiency.

Wachstein¹,

Moore²

1958

Experimental Biology and Medicine

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9015that increased weight gain in hypophysecte mized animals was achieved despite a significantly smaller quantity of f d ingested. When weight gains are corrected for amount of food ingested, increases in weight of the handled over unhandled group are greatly magnified. In the normal rat, handling has no influence on amount of food ingested( 6). The findings indicate that handling increases efficiency of food utilization (increased intestinal absorption and/or diminished metabdism) and that this effect is not dependent upon presence of pituitary or adrenal hormoines.It is apparent that increased skeletal growth previously reported in the handled normal young rat (6), is abolished by hypophysectomy. This suggests that the effect of handling on skeletal growth requires pituitary hormones, presumably growth hormone and/or thyrotropic hormone.It is pertinent to consider the contribution of handling to weight gains previously reported in hypophysectomized rats treated with insulin ( 13 ) or force-fed ( 14). Since these studies involved extra handling of experimental animals as compared with control animals, it is conceivable that weight gains observed were due in part to extra handling.Summary. Handling in young hypophysectomized rats resulted in significantly increased weight gain despite ingestion of significantly less food. No effect on skeletal growth or percentage of carcass protein and fat was observed. Increased weight gain in the handled hypophysectomized rat is due to greater efficiency of intestinal absorption of food and/or diminished metabolism rather than a direct stimulation of growth or increased food ingestion.We wish to acknowledge the {technical assistance of Y.

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Studies on Chronic Vitamin B6 Deficiency in the Rat II. Changes in Tissue Metabolism

Cited by 14 publications

References 11 publications

Detoxification of Commercial Linseed Meal for Use in Broiler Rations

Detoxification of Commercial Linseed Meal for Use in Broiler Rations

Body composition of rats in B-vitamin deficiencies

Pyridoxal Phosphate (B6-al-PO4) Levels in Organs, Leukocytes and Blood of Rats with Developing Vit. B6 Deficiency.

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