AMPHENONE-LIKE COMPOUNIIS 43 5 growth hormone or prolactin with doses as high as 200 and 500 pg. The presence of ICSH activity in the FSH preparation used is borne out by the reports of others.$ The problem of LH or ICSH activity in preparations of FSH is a topic of much discussion ( 10). Woods and Simpson ( 1 1 ) have recently stated, "No follicle stimulant of natural origin (pituitaries of any species, menopause or castrate serum or urine) is known which did not at some reIa,tiveIy low multiple of the minimal dose for follicledevelopment also show uterine s timulation and luteinization or interstitial cell stimulation. " Summmy. Experiments have been reported which indicate that a measurement of Z r P uptake by the dorsolateral prostate t Report on LH (ICSH) contaminatjon in NIH-FSH-S-1, oviiie by the Endocrinology Study Section, Nat. Inst. Health. of the hypophysectomized rat is a sensitive and specific bioassay for ICSH activity.1.
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