Studies on Bio-adhesion of Matrix Tablets: I. Release Profile of Theophylline Anhydrous

Shamsuddin, Md.; Akter, Parvin; Khan, Md. Ziaur Rahman; Chowdhury, Jakir Ahmed; Reza, Md. Selim

doi:10.3329/dujps.v5i1.226

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…The bioadhesive strength for the prepared buccoadhesive tablets were showed in figure 3. It was revealed that increasing the polymer amount increased bioadhesive strength due to providing more adhesive sites and polymer chains for interpenetration with mucin [19] .Also, the buccal tablets formulated with CP/HPMC (B1 to B4) showed stronger mucoadhesion than SA/HPMC formulations (A1 to A4) .this may be due to ability of CP to form secondary bioadhesion bonds with mucin and interpenetration of the polymer chains in the interfacial region, while other polymers, SA and HPMC undergo only superficial bioadhesion [17,20] .…”

Section: Bioadhesive Propertiesmentioning

confidence: 99%

Formulation and In-Vitro Evaluation of Mucoadhesive Diltiazem Hydrochloride Buccal Tablets

Sabri¹

2011

AJPS

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Mucoadhesive tablets for buccal administration of diltiazem hydrochloride were prepared as an alternative to available diltiazem HCl dosage forms. Two types of tablets were developed each containing two mucoadhesive components (hydroxypropylmethyl cellulose HPMC and sodium alginate) and (HPMC and carbopol) for each types, batches were produced by changing quantity of polymer. The formulations were tested for mucoadhesive performance and release pattern. In vitro bioadhesive strength studies showed that the HPMC/carbopol formulations were more bioadhesive and less drug release rate compared with HPMC/alginate formulations. Increasing the content of HPMC in HPMC/alginate tablets resulted in increase in detachment forces and swelling index but lower release rates were observed. The release behavior of all formulations was non-Fickian mechanism controlled by a combination of diffusion and chain relaxation mechanisms and best fitted zero-order kinetics.The buccoadhesive diltiazem HCl tablets containing 18.75% sodium alginate and 37.5% HPMC showed suitable release kinetics (n = 0.86, K0 zero order release = 10.29 mg/h, MDT = 4.8 h) , good adhesive properties and did not show any interaction between polymers and drug based on FT-IR study.

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Section: Bioadhesive Propertiesmentioning

confidence: 99%

Formulation and In-Vitro Evaluation of Mucoadhesive Diltiazem Hydrochloride Buccal Tablets

Sabri¹

2011

AJPS

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“…4 In our previous study Theophylline anhydrous was used as a model drug to develop, characterize and evaluate the bio-adhesive matrix tablets employing various bio-adhesive polymers for prolonged gastrointestinal absorption. 5 Our present study is designed to actually study the capacity of hydrophilic polymers as release retarding ingredient and muco-adhesive agent over drug molecule in its anhydrous and salt form in terms of dissolution study, retention time and subsequent data analysis.…”

Section: Introductionmentioning

confidence: 99%

Studies on Bio-adhesion of Matrix Tablets: II.Comparison on Bio-adhesion Strength and Release Profiles of Theophylline Anhydrous and Its Sodium Glycinate Salt

Islam

Khan

Khatun

et al. 2012

Dhaka Univ. J. Pharm. Sci

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Controlled release matrix tablets of Theophylline anhydrous and Theophylline sodium glycinate were prepared with different types of bio-adhesive polymers e.g. HPMC 15 & 50 cps, Gelatin, PVP K-30, Na-CMC and Xanthan gum. Tablets, prepared by direct compression method were subjected to in-vitro drug dissolution for 8 hours in 0.1 N hydrochloric acid (pH 1.2) using a thermal shaker at 50 rpm at 37 ± 0.5ºC. The bio-adhesive property was investigated in terms of retention time following in-vitro wash-off method by Lehr et al. The anhydrous and corresponding salt form was used to investigate whether physical variation of Theophylline molecule can cause any change in release and bio-adhesion property or not. In most of the cases it is found that salt form releases greater percentage of active drug than its corresponding anhydrous form. Irrespective of drug’s physical property and amount of polymer, bio-adhesive strength of Xanthan gum was proved to be maximum followed by HPMC- 50 cps, Na-CMC and HPMC- 15 cps, whereas gelatin and PVP K-30 showed little or poor muco-adhesion. Xanthan gum, Na-CMC and HPMC based formulations showed nearly zero-order release; on the contrary PVP K-30 based formulation showed a burst release within one hour of dissolution.DOI: http://dx.doi.org/10.3329/dujps.v10i1.10008DUJPS 2011; 10(1): 1-7

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Fabrication and Evaluation of Sustained Release Mucoadhesive Losartan Potassium Matrix Tablets

et al. 2015

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Sustained release matrix tablets of Losartan potassium were prepared with different types of mucoadhesive polymers e.g. Hydroxypropylmethyl cellulose (HPMC), Sodium carboxymethyl cellulose (Na-CMC) and Methyl cellulose (MC). The tablets were prepared by direct compression method and then were subjected to in-vitro drug dissolution for 8 hours in phosphate buffer of pH 6.8. The mucoadhesive property was investigated in terms of retention time by wash-off method. Irrespective of amount of polymer, mucoadhesive strength of MC was proved to be maximum where HPMC and Na-CMC showed moderate or poor mucoadhesive strength. Drug release from all formulations followed Higuchi release mechanism.

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Studies on Bio-adhesion of Matrix Tablets: I. Release Profile of Theophylline Anhydrous

Cited by 3 publications

References 11 publications

Formulation and In-Vitro Evaluation of Mucoadhesive Diltiazem Hydrochloride Buccal Tablets

Formulation and In-Vitro Evaluation of Mucoadhesive Diltiazem Hydrochloride Buccal Tablets

Studies on Bio-adhesion of Matrix Tablets: II.Comparison on Bio-adhesion Strength and Release Profiles of Theophylline Anhydrous and Its Sodium Glycinate Salt

Fabrication and Evaluation of Sustained Release Mucoadhesive Losartan Potassium Matrix Tablets

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