Polymeric films of Eudragit RS 100 were prepared by solvent casting method to explore the possibilities of using this polymer in transdermal therapeutic system (TTS). Naproxen was used as a model drug and incorporated in two different percent loading (8.3 % w/w and 20.8 % w/w of films). Effects of two plasticizers ( PEG 1500 and PEG 4000) and two release modifiers ( PVA and HPMC 15cps) on in vitro drug release from naproxen loaded eudragit RS films were assessed. Drug release was found to be a function of drug load, PEG molecular weight and physico-chemical property of the release modifiers incorporated. At low drug load, highest amount of drug was released from flims containing PEG 1500 (more than 95%). However, a burst release was evident in case of all the experimental batches except that loaded with HPMC 15 cps. With this formulation, more than 75 % of active principle was released after 8 hours while only 12 % of naproxen was liberated in the first hour of dissolution. Increasing drug load, increased the rate and extent of drug release from eudragit RS films; however this effect was minimized when PEG 4000 was used as release modifier. For PEG 1500 loaded films, drug release was decreased with increasing drug concentration in the TTS. Inclusion of PEG in eudragit RS films caused the drug to be released by diffusion (Fickian) kinetics whereas PVA and HPMC containing formulations released drug by diffusion mechanism coupled with erosion. Key words: Naproxen sodium, Eudragit RS 100, Controlled release. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
Background: The pyramidal lobe is also called the 3rd lobe of the thyroid gland which ascends toward the hyroid bone from the isthmus or the adjacent part of either lobe. A fibrous or fibromascular band the levetor glandulae thyroideae occasionally extends upwards from the apex of the pyramidal lobe to the body of the hyoid bone. Any pathology of thyroid gland involves this lobe, some pathology started from here or recurrence may occur from this lobe. Anatomical knowledge about pyramidal lobe is essential for surgeons, endocrinologists, pathologists and sonologists for proper diagnosis and management of thyroid diseases. Study design: Cross sectional descriptive type of study. Place and period of study: Department of Anatomy, Sir Salimullah Medical College, Dhaka. Study period was from July 2003 to June 2004. Materials: The study was done by examining 60 post mortem human thyroid glands, age ranging from 7 to 67 years. The glands were collected from unclaimed dead bodies autopsied in the morgue of Dhaka Medical College and Sir Salimullah Medical College under the department of Forensic Medicine. Methods: The collected sample were grouped in to three age groups including group A(0-20 years), group B (21-50 years) and group C (>50 years). The presence, variation of position of the pyramidal lobe and its relation with levator glandulae thyroideae were studied. Result: The pyramidal lobe was found in 16 of 60 thyroid glands in different age groups and situated more on the left side than the right. In 9 cases, levator glandulae thyroideae were found. All extended from the apex of the pyramidal lobe to the body of the hyoid bone. Key words: Pyramidal lobe; levator glandulae thyroideae; thyroid gland. DOI: 10.3329/jdmc.v18i2.6270 J Dhaka Med Coll. 2009; 18(2) : 120-123
Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae, primarily affecting the skin and peripheral nerves. To find out the clinical profile of leprosy patients the cross sectional observational type of study was carried out in outpatient Dept of Dermatology and Venereology at DMCH, Dhaka. Total 30 cases were included in this study. The mean age was found 28.7±11.3 years. Male were 21(70.0%) and female were 9(30.0%). It was observed that 10(33.3%) patients were diagnosed as having borderline tuberculoid, 5(16.7%) as tuberculoid, 1(3.3%) as borderline, 6(20.0%) as borderline lepromatous and 8(26.7%) as lepromatous. Eighteen (60.0%) patients had mutibacillary and 12(40.0%) had paucibacillary. 28(93.3%) patients had hypopigmented, 27(90.0%) had marked anaesthesia, 26(86.7%) had macule & patch, 18(60.0%) had obvious margin and 9(30.0%) had plaque. Majority patients had symptoms during 6 months to 1 year. Common clinical manifestations of leprosy were obvious margin, hypopigmented, marked anaesthesia, macule and ear lobe enlargement. CBMJ 2017 January: Vol. 06 No. 01 P: 03-07
Abstract:Renal biopsy tissues were taken from 142 suspected glomerulonephritic patients who were admitted into the Department of Nephrology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka and Combined Military Hospital (CMH)
Various forms of skin disease like psoriasis have been found to show disturbances in systemic calcium metabolism in some cases. Calcium is the major regulator of keratinocytes differentiation. The main objective of this study was to find out the serum calcium level of patients with psoriasis in comparison with control subjects without psoriasis. The present study was a case control study from July 2015 to June 2016. Consecutive type of sampling method was followed in this study. The case group was consisting of 30 psoriatic patients and the control group was consisting of 30 non psoriatic patients attended in Skin and VD department of Dhaka Medical College Hospital (DMCH) and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The mean age of the psoriatic group was 35.57±7.75 years (minimum 22 years and maximum 50 years), while it was 35.17±7.32 years (minimum 23 years and maximum 48 years) in the control group. The mean serum calcium level in psoriatic patients was 8.84±0.95 mg/dl (minimum 7.2mg/dl and maximum 10.2 mg/dl) while in controls it was 9.49±0.90 mg/dl (minimum 7.7 mg/dl and maximum 10.9 mg/dl). Statistical difference was observed between case and control participants with p-value <0.05. Hypocalcemia was observed in 33.33% psoriatic patients as compared 10% in controls (P value <0.05). In conclusion, serum calcium levels were lower in psoriatic patients than in control subjects. It is better to include dairy foods as calcium resource in daily diet of patients suffering from psoriasis. CBMJ 2016 July: Vol. 05 No. 02 P: 29-32
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