Studies of biochemical parameters in breast cancer with and without metastasis

Mishra, Sandhya; Sharma, Deepti; Sharma, Praveen

doi:10.1007/bf02872394

Cited by 40 publications

(29 citation statements)

References 15 publications

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“…The expression of GTP has been regarded as a marker of neoplastic progression in several experimental models such as rodent skin and liver chemical carcinogenesis (30). In a clinical study of patients with breast carcinoma, Mishra et al (31) established significantly higher blood levels of GTP in patients with metastasis vs. patients without metastasis and normal controls. Significantly higher levels of GTP have been reported also in a number of human malignant neoplasms, for example, ovary, colon, lung, and leukemia (32).…”

Section: Discussionmentioning

confidence: 99%

Glutamine Affects Glutathione Recycling Enzymes in a DMBA-Induced Breast Cancer Model

Kaufmann

Тодорова

Luo

et al. 2008

Nutrition and Cancer

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Malignancy depletes host glutathione (GSH) levels to increase treatment-related toxicity and increases itself to resist the treatments. Our previous studies have shown that dietary glutamine (GLN) prevented 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors through enhancing gut GSH release and reducing tumor GSH level. In addition, GSH synthesis, metabolism, and recycling are accomplished in gamma-glutamyl cycle. We hypothesized that the GLN prevention might be through a differential regulation of the gamma-glutamyl cycle enzymes. Female Sprague-Dawley rats were randomized into DMBA-tumor bearing, DMBA-treated, and control groups subdivided into GLN and water groups. GLN supplementation was given at 1 g/kg/day by gastric gavage. The activities and messenger RNA levels of gamma-glutamyl transpeptidase (GTP), gamma-glutamylcysteine synthetase (GCS), 5-oxo-L-prolinase (OPase), gamma-glutamyl transferase (GTF), and glutaminase (GLNase) were determined in gut mucosa and breast tumor using specific enzyme assays and semiquantitative reverse transcription polymerase chain reaction. GLN upregulated gut GTP, GCS, OPase, and GLNase in DMBA-tumor bearing, DMBA-treated, and/or control rats; however, it downregulated these enzymes in the tumor. The paradoxical effect of GLN on key GSH recycling enzymes in the gut versus tumor suggests that dietary supplemental GLN could be used in the clinical practice to increase the therapeutic index of cancer treatments by protecting normal tissues from, and sensitizing tumor cells to, chemotherapy and radiation-related injury.

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Section: Discussionmentioning

confidence: 99%

Glutamine Affects Glutathione Recycling Enzymes in a DMBA-Induced Breast Cancer Model

Kaufmann

Тодорова

Luo

et al. 2008

Nutrition and Cancer

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“…11 Several tumor markers are in vogue now a days, which include alpha-feto protein, Carcino embryonic antigen, Human chorionic gonadotrophin, Prostate specific antigen and relatively less specific makers like Lactate dehydrogenase, Alkaline phosphatase, ferritin and Gamma glutamyl transpeptidase etc. 12 Earlier studies reported that 21 days (3 weeks) of surgery seems to be too short a period for any significant change to occur in biochemical parameters and a longer follow up was needed to establish prognostic importance. 6 Hence, our study conducted with minimum samples immediate after treatment, further follow-up studies with large samples were warranted.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

IJPSR

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Oral squamous cell carcinoma is one of the leading causes of mortality in India. The various haematological and biochemical changes including liver enzymes imbalance occur in cancer treatment. The careful monitoring of serum biochemical and haematological changes had very important role in prognosis of disease. Therefore, the present study aimed to study haematological and biochemical changes in pre and post treatment of buccal mucosa carcinoma patients. In study, totally 198 buccal mucosa carcinoma subjected were included from both genders. We observed the Haematological parameters (level of completer haemogram, differential leucocytes count), biochemical and liver function parameters in pre and post treatment of subjects. The serum biochemical and haematological levels were lower in post treatment groups than before treatment of subjects, whereas glucose level did not show significant changes. Hence, the subjects did not affected by diabetics. Most of subjects had anaemic, treatment severely affected bone marrow. However, these changes were exists statistically significant by paired samples t-test at p˂0.001. The biochemical and haematological changes were additional risk for subjects. Thus, these changes will help the prognosis and proper monitoring of the cancer subjects.

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“…1 Unfortunatey in most of the cases of cancer, symptoms are not produced until the tumors are either too large to be removed surgically or metastasis has taken place. 2 In normal physiological conditions each tissue maintains a steady and consistent enzymatic pattern which is altered significantly in malignancy as the constituents are shed into surrounding milieu at an increased rate when cells replicate more rapidly. Cancer is a proliferative and invasive disease and tumor cells respire anaerobically.…”

Section: Introductionmentioning

confidence: 99%

“…There is therefore need for simple biochemical investigations which can be easily assayed, are less expensive and can detect metastases. 2 Hence, present study was undertaken to evaluate the importance of assessing the serum levels of Lactate Dehydrogenase (LDH) and Alkaline Phosphatase (ALP) in patients of carcinoma breast and also to correlate probable relationship between serum levels of these tumor markers and stages of breast cancer.…”

Section: Introductionmentioning

confidence: 99%